Dataset: Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Arjaans, S. (Creator), Wagner, B. D. (Creator), Mourani, P. M. (Creator), Mandell, E. W. (Creator), Poindexter, B. (Creator), Berger, R. (Creator), Abman, S. H. (Creator), Dryad Digital Repository, 20-Jan-2020
Methods: We prospectively enrolled infants with gestational age <34 weeks gestation and collected blood samples during their first week of life. BPD and PH were assessed at 36 weeks postmenstrual age. Samples were assayed for each of the 1121 peptides included in the SOMAscanTM technology, with subsequent pathway analysis.
Results: Of 102 study infants, 82 had BPD and 13 had PH. Multiple angiogenic proteins (PF-4, VEGF121, ANG-1, BMP10, HGF, ANG2) were associated with the subsequent diagnosis of BPD, and FGF-19, PF-4, CTAP-III and PDGF-AA levels were associated with BPD severity. Early increases in BMP10 was strongly associated with the late risk for BPD and PH.
|Date made available||20-Jan-2020|
|Publisher||Dryad Digital Repository|
|Access to the dataset||Open|
- bronchopulmonary dysplasia, pulmonary hypertension, SOMAscanTM technology, angiogenic proteins, PF-4, VEGF121, ANG-1, BMP10, HGF, ANG2, FGF-19, CTAP-III, PDGF-AA
Keywords on Datasets