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Closing the door: Breaking new ground related to a potential anticancer drug target

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In order to sustain fast growth, cancer cells need to take up nutrients at a faster rate than healthy cells. The human glutamine transporter ASCT2 allows the amino acid glutamine to enter cells and is upregulated in many types of cancer cells, which need more glutamine. It is a potential target for new anti-cancer drugs. Researchers have now elucidated a structure of the human ASCT2 that provides unprecedented insight in the workings of this protein.


Related Publications
  1. A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

    Garaeva, A. A., Guskov, A., Slotboom, D. J. & Paulino, C., 31-Jul-2019, In : Nature Communications. 10, 8 p., 3427.

    Research output: Contribution to journalArticleAcademicpeer-review

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