BJOG : An International Journal of Obstetrics and Gynaecology (Journal)

Activity: Publication peer-review and editorial workPublication peer-reviewAcademic

Hendrik Groen - Editor


Commentary in BJOG about unripe cervix paper Thomas Bernardes.
OBJECTIVE:To evaluate caesarean section and adverse neonatal outcome rates after induction of labour or expectant management in women with an unripe cervix at or near term.
DESIGN:Secondary analysis of data from two randomised clinical trials.
SETTING:Data were collected in two nationwide Dutch trials.
POPULATION:Women with hypertensive disease (HYPITAT trial) or suspected fetal growth restriction (DIGITAT trial) and a Bishop score ≤6.
METHODS:Comparison of outcomes after induction of labour and expectant management.
MAIN OUTCOME MEASURES:Rates of caesarean section and adverse neonatal outcome, defined as 5-minute Apgar score ≤6 and/or arterial umbilical cord pH <7.05 and/or neonatal intensive care unit admission and/or seizures and/or perinatal death.
RESULTS:Of 1172 included women with an unripe cervix, 572 had induction of labour and 600 had expectant management. We found no significant difference in the overall caesarean rate (difference -1.1%, 95% CI -5.4 to 3.2). Induction of labour did not increase caesarean rates in women with Bishop scores from 3 to 6 (difference -2.7%, 95% CI -7.6 to 2.2) or adverse neonatal outcome rates (difference -1.5%, 95% CI -4.3 to 1.3). However, there was a significant difference in the rates of arterial umbilical cord pH <7.05 favouring induction (difference -3.2%, 95% CI -5.6 to -0.9). The number needed to treat to prevent one case of umbilical arterial pH <7.05 was 32.
CONCLUSIONS:We found no evidence that induction of labour increases the caesarean rate or compromises neonatal outcome as compared with expectant management. Concerns over increased risk of failed induction in women with a Bishop score from 3 to 6 seem unwarranted.
TWEETABLE ABSTRACT:Induction of labour at low Bishop scores does not increase caesarean section rate or poor neonatal outcome.

ID: 55568090