Publications Nutritional Immunology

Michela Ferrari, Lisanne Hameleers, Marc C.A. Stuart, Marjolein M.P. Oerlemans, Paul de Vos, Edita Jurak, Marthe T.C. Walvoort. Efficient isolation of membrane-associated exopolysaccharides of four commercial bifidobacterial strains. Carbohydrate Polymers DOI.org/10.1016/j.carbpol.2021.118913

C. Fernandez-Lainez, R. Akkerman, M.M.P. Oerlemans , M.J. Logtenberg , H.A. Schols, L.A. Silva-Lagos, G. Lopez-Velazquez and P. de Vos. β(2→6)-Type fructans attenuate proinflammatory responses in a structure dependent fashion via Toll-like receptors. Carbohydrate Polymers DOI.org/10.1016/j.carbpol.2021.118893

Chunli Kong, Renate Akkerman, Cynthia E. Klostermann, Martin Beukema, Marjolein M. P. Oerlemans, Henk A. Schols and Paul de Vos. Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of Lactobacillus plantarum WCFS1 to gut epithelial cells. Food & Function. DOI.org/10.1039/D1FO02563E

Jiahong Li, Xiaohua Pan, Zhengnan Ren, Binbin Li, He Liu, Chengfei Wu, Xiaoliang Dong, Paul de Vos, Li-Long Pan & Jia Sun. Protein arginine methyltransferase 2 (PRMT2) promotes dextran sulfate sodium-induced colitis by inhibiting the SOCS3 promoter via histone H3R8 asymmetric dimethylation. British Pharmacological Societ y DOI.org/10.1111/bph.15695

Eva Jermendi, Martin Beukema, Marco A. van den Berg , Paul de Vos, Henk A. Schols. Revealing methyl-esterification patterns of pectins by enzymatic fingerprinting: Beyond the degree of blockiness. Carbohydrate Polymers (Elsevier) DOI.org/10.1016/j.carbpol.2021.118813

Cynthia Fernández-Lainez, Ignacio de la Mora-de la Mora , Itzhel García-Torres, Sergio Enríquez-Flores, Luis A. Flores-López, Pedro Gutiérrez-Castrellón, Lilian Yépez-Mulia, Felix Matadamas-Martínez, Paul de Vos and Gabriel López-Velázquez. Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase. International Journal of Molecular Sciences DOI.org/10.3390/ijms22179491

Renate Akkerman Madelon J. Logtenberg, Martin Beukema, Bart J. de Haan, Marijke M. Faas, Erwin G. Zoetendal, Henk A. Scholsb and Paul de Vos. Chicory inulin enhances fermentation of 2’-fucosyllactose by infant fecal microbiota and differentially influences immature dendritic cell and T-cell cytokine responses under normal and Th2-polarizing conditions. Food & Function (Royal Society of Chemistry) DOI.org/10.1039/D1FO00893

Chunli Kong, Martin Beukema, Min Wang, Bart J. de Haan and Paul de Vos Human milk oligosaccharides and non-digestible carbohydrates prevent adhesion of specific pathogens via modulating glycosylation or inflammatory genes in intestinal epithelial cells. Food & Function (Royal Society of Chemistry) DOI.org/10.1039/D1FO00872B

Martin Beukema, Renate Akkerman, Éva Jermendi, Taco Koster, Anne Laskewitz, Chunli Kong, Henk A. Schols, Marijke M. Faas, and Paul de Vos. Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis. Molecular Nutrition & Food Research (MNF journal) DOI.org/10.1002/mnfr.202100346

Martin Beukema, Éva Jermendi, Taco Koster, Kohji Kitaguchi, Bart J. de Haan, Marco Alexander van den Berg, Marijke M. Faas, Henk A. Schols, and Paul de Vos. Attenuation of Doxorubicin-Induced Small Intestinal Mucositis by Pectins is Dependent on Pectin’s Methyl-Ester Number and Distribution. Molecular Nutrition & Food Research (MNF journal) DOI.org/10.1002/mnfr.202100222

Luis A. Silva-Lagos, Janesh Pillay, Matijs van Meurs, Alexandra Smink,Peter H. J. van der Voort and Paul de Vos. DAMPening COVID-19 Severity by Attenuating Danger Signals. Frontiers in Immunology DOI.org/10.3389/fimmu.2021.720192

Susana Figueroa-Lozano, Renate Akkerman, Martin Beukema, Sander S. van Leeuwen, Lubbert Dijkhuizen & Paul de Vos. 2′-Fucosyllactose impacts the expression of mucus-related genes in goblet cells and maintains barrier function of gut epithelial cells. Journal of Functional Food DOI:/10.1016/j.jff.2021.104630

Madelon J. Logtenberg, Renate Akkerman, Rosan G. Hobé, Kristel M. H. Donners, Sander S. Van Leeuwen, Gerben D. A. Hermes, Bart J. de Haan, Marijke M. Faas, Piet L. Buwalda, Erwin G. Zoetendal, Paul de Vos, and Henk A. Schols. Structure-Specific Fermentation of Galacto-Oligosaccharides, Isomalto-Oligosaccharides and Isomalto/Malto-Polysaccharides by Infant Fecal Microbiota and Impact on Dendritic Cell Cytokine Responses. Molecular Nutrition & Food Research (mnf-journal) DOI:/10.1002/mnfr.202001077

Naschla Gasaly, Paul de Vos and Marcela A. Hermoso. Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation. Frontiers in Immunology DOI:/10.3389/fimmu.2021.658354

C.E. Klostermann, P.L. Buwalda, H. Leemhuis, P. de Vos, H.A. Schols, J.H. Bitter. Digestibility of resistant starch type 3 is affected by crystal type, molecular weight and molecular weight distribution. Carbohydrate Polymers (Elsevier) DOI:/10.1016/j.carbpol.2021.118069

Lianghui Cheng, Chunli Kong, Wenjia Wang, Andre Groeneveld, Arjen Nauta, Matthew R. Groves, Mensiena B. G. Kiewiet and Paul de Vos. The Human Milk Oligosaccharides 3-FL, Lacto-N-Neotetraose, and LDFT Attenuate Tumor NecrosisFactor-α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1. Molecular Nutrition & Food Research Journal DOI:/10.1002/mnfr.202000425

M. Beukema, K. Ishisono, J. de Waard, M. M. Faas, P. de Vos and K. Kitaguchi. Pectin limits epithelial barrier disruption by Citrobacter rodentium through anti-microbial effects. Food & Function. DOI:/10.1039/D0FO02605K

M. Beukema, E. Jermendi, M.A. van den Berg, M.M. Faas, H.A. Schols, P. de Vos. The impact of the level and distribution of methyl-esters of pectins onTLR2-1 dependent anti-inflammatory responses. Carbohydrate Polymers (Elsevier) DOI:/10.1016/j.carbpol.2020.117093

Marjolein M.P. Oerlemans , Renate Akkerman, Michela Ferrari, Marthe T.C. Walvoort, Paul de Vos. Benefits of bacteria-derived exopolysaccharides on gastrointestinal microbiota, immunity and health Journal of Functional Foods. DOI:/10.1016/j.jff.2020.104289

Lianghui Cheng, Mensiena B. G. Kiewiet, Madelon J. Logtenberg,Andre Groeneveld, Arjen Nauta, Henk A. Schols, Marthe T. C. Walvoort, Hermie J. M. Harmsen and Paul de Vos. Effects of Different Human Milk Oligosaccharides on Growth of Bifidobacteria in Monoculture and Co-culture With Faecalibacterium prausnitzii. Frontiers in Microbiology. DOI:10.3389/fmicb.2020.569700

Martin Beukema, Marijke M. Faas and Paul de Vos. The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells. Experimental & Molecular Medicine. DOI:10.1038/s12276-020-0449-2

Shuxian Hu, Rei Kuwabara, Martin Beukema, Michela Ferrari, Bart J. de Haan, Marthe T.C. Walvoort, Paul de Vos, Alexandra M. Smink. Low methyl-esterified pectin protects pancreatic β-cells against diabetes induced oxidative and inflammatory stress via galectin-3. Elsevier - Carbohydrate Polymers. DOI:1016/j.carbpol.2020.116863

Madelon J. Logtenberg, Kristel M. H. Donners, Jolien C. M. Vink, Sander S. van Leeuwen, Pieter de Waard, Paul de Vos, and Henk A. Schols. Touching the High Complexity of Prebiotic Vivinal Galactooligosaccharides Using Porous Graphitic Carbon Ultra-High-Performance Liquid Chromatography Coupled to Mass Spectrometry. Journal of Agricultural and Food Chemistry. DOI/10.1021/acs.jafc.0c02684

Renate Akkerman, Madelon J. Logtenberg, Ran An, Marco A. Van Den Berg , Bart J. de Haan, Marijke M. Faas, Erwin Zoetendal , Paul de Vos and Henk A. Schols. Endo-1,3(4)-β-Glucanase-Treatment of Oat β-Glucan Enhances Fermentability by Infant Fecal Microbiota, Stimulates Dectin-1 Activation and Attenuates Inflammatory Responses in Immature Dendritic Cells. Nutrients 2020. DOI/10.3390/nu12061660

Alexandra M. Smink, Avid Najdahmadi, Michael Alexander, Shiri Li, Samuel Rodriquez, Harry van Goor, Jan-Luuk Hillebrands, Elliot Botvinick. The Effect of a Fast-Releasing Hydrogen Sulfide Donor on Vascularization of Subcutaneous Scaffolds in Immunocompetentand Immunocompromised Mice. Biomolecules. DOI:10.3390/biom10050722

Chengcheng Ren, Marijke M. Faas and Paul de Vos. Disease managing capacities and mechanisms of host effects of lactic acid bacteria. (Critical Reviews in) in Food Science and Nutrition. DOI:10.1080/1040 8398.2020.1758625

Lianghui Cheng, Renate Akkerman, Chunli Kong, Marthe T.C. Walvoort and Paul de Vos. More than sugar in the milk: human milk oligosaccharides as essential bioactive molecules in breast milk and current insight in beneficial effects. Food Science and Nutrition (critical reviews). DOI:10.1080/10408398

Susana Figueroa-Lozano, Chengcheng Ren, Huifang Yin, Hien Pham, Sander van Leeuwen, Lubbert Dijkhuizen and Paul de Vos. The impact of oligosaccharide content, glycosidic linkages and lactose content of galacto-oligosaccharides (GOS) on the expression of mucus-related genes in globet cells. Food & Function Journal DOI:10.1039/D0FO00064G

Chengcheng Ren, Qiuxiang Zhang, Bart J. de Haan, Marijke M. Faas, Hao Zhang and Paul de Vos. Protective effects of lactic acid bacteria on gut epithelial barrier dysfunction are Toll like receptor 2 and protein kinase C dependent. Food & Function DOI:10.1039/C9FO02933H

Samira B. R. Prado, Martin Beukema, Eva Jermendi, Henk A. Schols, Paul de Vos & João Paulo Fabi. Pectin Interaction with Immune Receptors is Modulated by Ripening Process in Papayas. Nature- Scientific Reports. DOI:10.1038/s41598-020-58311-0

Chengcheng Ren, Lianghui Cheng, Yue Sun, Qiuxiang Zhang, Bart J. de Haan, Hao Zhang, Marijke M. Faas en Paul de Vos. Lactic acid bacteria secrete toll like receptor 2 stimulating and macrophage immunomodulating bioactive factors. Journal of Functional Foods. DOI10.1016/j.jff.2020.103783

Ellen Wilms, Freddy J. Troost, Montserrat Elizalde, Bjorn Winkens, Paul de Vos, Zlatan Mujagic, Daisy M. A. E. Jonkers & Ad A. M. Masclee. Intestinal barrier function is maintained with aging – a comprehensive study in healthy subjects and irritable bowel syndrome patients. Scientific Reports 2020. DOI:10.1038/s41598-019-57106-2

Marijke M. Faas, Yuanrui Liu, Theo Borghuis, Carolien A. van Loo-Bouwman, Hermie Harmsen and Paul de Vos. Microbiota Induced Changes in the Immune Response in Pregnant Mice. Frontiers in Immunology 2019. DOI: 10.3389/fimmu.2019.02976

Lianghui Cheng, Chunli Kong, Marthe T. C. Walvoort, Marijke M. Faas, and Paul de Vos. Human Milk Oligosaccharides Differently Modulate Goblet Cells Under Homeostatic, Proinflammatory Conditions and ER Stress. Molecular Nutrition & Food Research, December 2019. DOI:10.1002/mnfr.201900976

Alexia F. P . Lépine, Prokopis Konstanti, Klaudyna Borewicz, Jan-Willem Resink, Nicole J. de Wit, Paul de Vos, Hauke Smidt & Jurriaan J. Mes. Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets. Nature – Scientific Reports. 2019. DOI:1 0.1038/s41598-019-54353-1

Arno R. Bourgonje, Julius Z. H. von Martels, Ruben Y. Gabriëls, Tjasso Blokzijl,Manon Buist-Homan, Janette Heegsma, Bernadien H. Jansen, Hendrik M. van Dullemen, Eleonora A. M. Festen, Rinze W. F. ter Steege, Marijn C. Visschedijk, Rinse K. Weersma, Paul de Vos, Klaas Nico Faber and Gerard Dijkstra. A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. F rontiers in Medicine, Nov. 2019. DOI:10.3389/fmed.2019.00251

Ran An, Ellen Wilms, Agnieszka Smolinska, Gerben D.A. Hermes, Ad A.M. Masclee, Paul de Vos, Henk A. Schols, Frederik J. van Schooten, Hauke Smidt, Daisy M.A.E. Jonkers, Erwin G. Zoetendal and Freddy J. Troost. Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly. Nutrients. Sept 2019. DOI:10.3390/nu11092193

Lingmin Tian, Jan Scholte, Anton J.W. Scheurink ,Marco van den Berg, Geert Bruggeman, Erik Bruininx, Paul de Vos, Henk A. Schols, Harry Gruppen. Effect of oat and soybean rich in distinct non-starch polysaccharides on fermentation, appetite regulation and fat accumulation in rat. Int ernational Journal of Biological Macromolecules, Elsevier. 2019. DOI:10.1016/j.ijbiomac.2019.08.032

Chengfei Wu, Li-Long Pan, Yang Luo, Wenying Niu, Xin Fang, Wenjie Liang, Jiahong Li, Hongli Li, Xiaohua Pan, Guilian Yang, Wei Chen, Hao Zhang, Jonathan R. T. Lakey, Birgitta Agerberth, Paul de Vos, and Jia Sun. Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction. Molecular Nutrition & Food Research, July 2019. DOI:10.1002/mnfr.201900307

Wu C, Pan L-L, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P and Sun J. Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice. Frontiers in Immunologly, July 2019. DOI:/10.3389/fimmu.2019.01733

Ellen Wilms, Daisy M.A.E. Jonkers, Huub F.J. Savelkoul, Montserrat Elizalde, Lea Tischmann, Paul de Vos, Ad A.M. Masclee and Freddy J. Troost. The Impact of Pectin Supplementation on Intestinal Barrier Function in Healthy Young Adults and Healthy Ederly. Nutrients. 2019/11. DOI: 10.3390/nu11071554

Chunli Kong, Marlies Elderman, Lianghui Cheng, Bart J. de Haan, Arjen Nauta and Paul de Vos. Modulation of Intestinal Epithelial Glycocalyx Development by Human Milk Oligosaccharides and Non-Digestible Carbohydrates. Molecular Nutrition & Food Research. 2019. DOI: 10.1002/mnfr.201900303

Lianghui Cheng, Mensiena B.G. Kiewiet, Andre Groeneveld, Arjen Nauta, Paul de Vos. Human milk oligosaccharides and its acid hydrolysate LNT2 show immunomodulatory effects via TLRs in a dose and structure-dependent way. Journal of Functional Foods. 2019. DOI: 10.1016/j.jff.2019.05.023

Stella Verkhnyatskaya, Michela Ferrari, Paul de Vos and Marthe T. C. Walvoort. Shaping the Infant Microbiome With Non-digestible Carbohydrates. Frontiers in Microbiology. 2019. DOI:10.3389/fmicb.2019.00343

Susana Figueroa-Lozano and Paul de Vos. Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier. Comprehensive reviews in Food Science and Food Safety. 2018 DOI:10.1111/1541-4337.12400

Adriaan A. van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F. Knol and Huub F. J. Savelkoul Aged mice display altered numbers and phenotype of basophils, and bone marrowderived basophil activation, with a limited role for aging-associated microbiota Immunity & Ageing. 2018. DOI:10.1186/s12979-018-0135-6

Alexia F.P. Lépine, Roderick H. J. de Hilster, Hans Leemhuis, Lizette Oudhuis, Piet L. Buwalda, and Paul de Vos. Higher Chain Length Distribution in Debranched Type-3 Resistant Starches (RS3) Increases TLR Signaling and Supports Dendritic Cell Cytokine Production. Molecular Nutrition Food Research. 2018. DOI: 10.1002/mnfr.201801007

Mensiena B. G. Kiewiet, Renske Dekker, Martine P. van Gaal, Laurien H. Ulfman, Andre Groeneveld, Marijke M. Faas and Paul de Vos. Identification of a TLR2 Inhibiting Wheat Hydrolysate. Molecular Nutrician Food Research. 2018, 1800716. DOI: 10.1002/mnfr.201800716

Susana Figueroa-Lozano and Paul de Vos. Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier. Comprehensive Reviews in Food Science and Food Safety. 2018, Vol. 00. Doi: 10.1111/1541-4337.12400

Annemarie Baars, Annemarie Oosting, Mirjam Lohuis, Martijn Koehorst, Sahar ElAidy, Floor Hugenholtz, Hauke Smidt, Mona Mischke, Mark V. Boekschoten, Henkjan J. Verkade, Johan Garssen, Eline M. van der Beek, Jan Knol, Paul de Vos, Jeroen van Bergenhenegouwen & Floris Fransen. Sex differences in lipid metabolism are affected by presence of the gut microbiota.
Scientific Reports.  2018. 8:13426. DOI:10.1038/s41598-018-31695-w11

Alexia Lépine and Paul de Vos. Synbiotic Effects of the Dietary Fiber Long-Chain Inulin and Probiotic Lactobacillus acidophilus W37 Can be Caused by Direct, Synergistic Stimulation of Immune Toll-Like Receptors and Dendritic Cells. Molecular Nutrition Food Research. 2018. 1800251. DOI: 10.1002/mnfr.201800251

Mensiena B. G. Kiewiet, Marijke M. Faas and Paul de Vos. Immunomodulatory Protein Hydrolysates and Their Application. Nutrients. 2018. Vol. 10, 904.
DOI: 10.3390/nu10070904

Alexia F. P. Lépine, Nicole de Wit, Els Oosterink, Harry Wichers, Jurriaan Mes and Paul de Vos. Lactobacillus acidophilus Attenuates Salmonella-Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses. Frontiers in Microbiology. 2018, Vol. 9, 1439.
DOI: 10.3389/fmicb.2018.01439

Marlies Elderman, Floor Hugenholtz, Clara Belzer, Mark Boekschoten, Bart de Haan, Paul de Vos, Marijke Faas. Changes in intestinal gene expression and microbiota composition during late pregnancy are mouse strain dependent. Scientific Reports. 2018. Vol. 8, Article nr: 10001. DOI 10.1038/s41598-018-28292-2

Marlies Elderman, Paul de Vos and Marijke Faas: Role of Microbiota in Sexually
Dimorphic Immunity. Frontiers in Immunology. 2018.
DOI: 10.3389/fimmu.2018.01018

Neha M. Sahasrabudhe, Martin Beukema, Lingmin Tian, Berit Troost, Jan Scholte,
Erik Bruininx, Geert Bruggeman, Marco van den Berg, Anton Scheurink,
Henk A. Schols, Marijke M. Faas and Paul de Vos. Dietary Fiber Pectin Directly Blocks Toll-like receptor 2–1 and Prevents Doxorubicin-induced ileitis. Frontiers in Immunology. 2018. Vol 9. DOI: 10.3389/fimmu.2018.00383

Chengcheng Ren, Jelleke Dokter-Fokkens, Susana Figueroa Lozano, Qiuxiang Zhang, Bart J. de Haan, Hao Zhang, Marijke M. Faas and Paul de Vos: Lactic Acid Bacteria May Impact Intestinal Barrier Function by Modulating Goblet Cells.
DOI: 10.1002/mnfr.201700572

Arno R. Bourgonje, Julius Z. H. von Martels, Paul de Vos, Klaas Nico Faber, Gerard Dijkstra: Increased fecal calprotectin levels in Chrohn's disease correlate with elevated serum Th1- and Th17-associated cytokines. DOI:10.1016/j.crohns.2009.12.002

Miriam Bermudez-Brito, Theo Borghuis, Catherine Daniel, Bruno Pot, Bart J. de Haan, Marijke M. Faas & Paul de Vos (2018): L. plantarum WCFS1 enhances Treg frequencies by activating DCs even in absence of sampling of bacteria in the Peyer Patches. Scienctific Reports.  DOI:10.1038/s41598-018-20243-1

S. Figueroa-Lozano , R. L. Valk-Weeber , S. S. van Leeuwen , L. Dijkhuizen , P. de Vos (2018) Dietary N-Glycans from Bovine Lactoferrin and TLR Modulation , Mol. Nutr. Food Res.2018, 62, 1700389. https://doi.org/10.1002/mnfr.201700389

Renate Akkerman, Marijke M. Faas & Paul de Vos (2018): Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation, Critical Reviews in Food Science and Nutrition, doi: 10.1080/10408398.2017.1414030

Kiewiet M, Dekkers R, Ulfman L.H, Groenveld A, Vos de P, Faas M.M (2017) Immunomodulating protein aggregates in soy and whey hydrolysates and their resistance to digestion in an in vitro infant gastrointestinal model: new insights in the mechanism of immunomodulatory hydrolysates. doi: 10.1039/c7fo01537b

Fransen F, van Beek AA, Borghuis T, Aidy SE, Hugenholtz F, van der  Gaast – de Jongh C, Savelkoul HFJ, De Jonge MI, Boekschoten MV, Smidt H, Faas MM and de Vos P (2017) Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice. Front. Immunol. 8:1385. doi: 10.3389/fimmu.2017.01385

Kanj P, Sahasrabudhe NM, de Haan BJ, de Vos P (2017) Immune effects of b-glucan are determined by combined effects on Dectin-1, TLR2, 4 and 5. doi: 0.1016/j.jff.2017.07.061

Elderman M, Sovran B, Hugenholtz F et. al (2017) The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice. doi: 10.1371/journal.pone.0184274

He Y, Wu C, Li, J et. al (2017) Inulin-Type Fructans Modulates Pancreatic–Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. doi: 10.3389/fimmu.2017.01209

de Vos P, Mujagic, Z. de Haan, et al. (2017). Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells. doi: 10.3389/fimmu.2017.01000

Kiewiet MBG, van Esch BCAM, Garssen J, Faas MM, de Vos P (2017) Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies. Mol Nutr Food Res. 2017 Jul 5. doi: 10.1002/mnfr.201700340

Fransen F, van Beek AA, Borghuis T, Meijer B, Hugenholtz F, van der Gaast-de Jongh C, Savelkoul HF, de Jonge MI, Faas MM, Boekschoten MV, Smidt H, El Aidy S and de Vos P (2017) The Impact of Gut Microbiota on Gender-Specific Differences in Immunity. Front. Immunol. 8:754. doi: 10.3389/fimmu.2017.00754

Kiewiet MBG, Dekkers R, Gros M, van Neerven RJJ, Groeneveld A, de Vos P, et al. (2017) Toll-like receptor mediated activation is possibly involved in immunoregulating properties of cow's milk hydrolysates. PLoS ONE 12(6): e0178191. doi.org/10.1371/journal.pone.0178191

Vogt LM, Elderman ME, Borghuis T, de Haan BJ, Faas MM, de Vos P. Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B. Mol Nutr Food Res. doi: 10.1002/mnfr.201700171

Chen K, Chen H, Faas MM, De Haan B, Li J, Xiao P, Zhang H, Diana J, De Vos P, Sun J. (2017) Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function and microbiota homeostasis. Mol. Nutr. Food Res. doi: 10.1002/mnfr.201601006

Sun Y, He Y, Wang F, Zhang H, De Vos P and Sun J (2017) Low-methoxyl lemon pectin attenuates inflammatory responses and improves intestinal barrier integrity in caerulein-induced experimental acute pancreatitis. Mol. Nutr. Food Res. DOI 10.1002/mnfr.201600885

Fransen F, Sahasrabudhe NM, Elderman M, Bosveld M, El Aidy S, Hugenholtz F, Borghuis T, Kousemaker B, Winkel S, Van der Gaast de Jongh C, De Jonge MI, Van Boekschoten M, Smidt H, Schols HA and De Vos P. (2017) β2→1-Fructans Modulate the immune system In Vivo in a Microbiota-Dependent and -independent Fashion. Frontiers in Immunology. doi: 10.3389/fimmu.2017.00154

Mujagic Z, De Vos P, Van Boekschoten M, Govers C, Pieters HJHM, De Wit NJW, Bron PA, Masclee AAM, Troost FJ. (2017) The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Scientific Reports. 7:40128 | DOI: 10.1038/srep40128

Van Beek AA, Sovran B, Hugenholtz F, Meijer B, Hoogerland JA, Mihailova V, Van der Ploeg C, Belzer C, Boekschoten MV, Hoeijmakers JHJ, Vermeij WP, De Vos P, Wells JM, Leenen PJM, Nicoletti C, Hendriks RW, SavelkoulHFJ. (2016) Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1^−/Δ7 Mice. Frontiers in Immunology. doi: 10.3389/fimmu.2016.00408

Ren C, Zhang Q, De Haan BJ, Zhang H, Faas MM, De Vos P. (2016) Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation. Scientific Reports. doi:10.1038/srep34561

Van Beek AA, Hugenholtz F, Meijer M, Sovran B, Perdijk O, Vermeij WP, Brandt RMC, Barnhoorn S, Hoeijmakers JHJ, De Vos P, Leenen PJM, Hendriks RW, Savelkoul HFJ. (2016) Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1 mice. JLB . doi:10.1189/jlb.1HI0216-062RR

Bermudez-Brito M, Faas MM, De Vos P. (2016) Modulation of dendritic-epithelial cell responses against sphingomonas paucimobilis by dietary fibers. Scientific Reports. doi:10.1038/srep30277

Sahasrabudhe NM, Dokter-Fokkens J, De Vos P. (2016) Particulate β-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells. Mol Nutr Food Re s. doi: 10.1002/mnfr.201600356

Tian L, Bruggeman G, Van den Berg M, Borewicz K, Scheurink AJ, Bruininx E, De Vos P, Smidt H, Schols HA, Gruppen H. (2016) Effects of pectin on fermentation characteristics, carbohydrate utilization and microbial community composition in the gastrointestinal tract of weaning pigs. Mol Nutr Food Res. doi: 10.1002/mnfr.201600186

Elderman M, Van Beek A, Brandsma E, De Haan BJ, Savelkoul H, De Vos P and Faas MM. (2016) Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner. Biology of Sex Differences. 7:21/DOI 10.1186/s13293-016-0075-9

Sovran B, Lu P, Loonen LMP, Hugenholtz F, Belzer C, Stolte EH, Van Boekschoten M, Van Baarlen P, Smidt H, Kleerebezem M, De Vos P, Renes IB, Wells JM, Dekker J. (2016) Identification of commensal species positively correlated with early stress responses to a compromised mucus barrier. Inflamm Bowel Dis. DOI 10.1097/MIB.0000000000000688/ibd 2016;0:1–15

Vogt LM, Sahasrabudhe NM, Ramasamy U, Meyer D, Pullens G, Faas MM, Venema K, Schols HA, De Vos P. (2016) The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function. Jounal of Functional Foods 22. dx.doi.org/10.1016/j.jff.2016.02.002

Sahasrabudhe NM, Lingmin Tian, Van den Berg M, Bruggeman G, Bruininx E, Schols HA, Faas MM, De Vos P. (2016). Endo-glucanase digestion of oat β-Glucan enhances Dectin-1 activation in human dendritic cells. Journal of Functional Foods 21. dx.doi.org/10.1016/j.jff.2015.11.037

Van Beek AA, Hoogerland JA, Belzer C, De Vos P, Savelhoul HFJ, Leenen PJM. (2015) Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response. Beneficial Microbes. DOI 10.3920/BM2015.0094

Sahasrabudhe NM, Schols HA, Faas MM and De Vos P. (2015) Arabinoxylan activates Dectin-1 and modulates particulate ß-glucan-induced Dectin-1 activation. Mol. Nutr. Food Res. 00,1–10 DOI 10.1002/mnfr.201500582

Vogt LM, Van Boekschoten M, De Groot PJ, Faas MM, De Vos P. (2015) Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells. Journal of Functional Foods 18. 520–531/dx.doi.org/10.1016/j.jff.2015.08.011520–531

Bermudez-Brito M, Rösch C, Schols HA, Faas MM, De Vos P (2015) Resistant starches differentially stimulate Toll-like receptors and attenuate proinflammatory cytokines in dendritic cells by modulation of intestinal epithelial cells Mol. Nutr. Food Res. doi 10.1002/mnfr.201500148

Kiewiet MBG, Gros M, Van Neerven RJJ, Faas MM, De Vos P. (2015) Immunomodulating properties of protein hydrolysates for application in cow’s milk allergy. Pediatric Allergy and Immunology doi:10.1111/pai.12354/26: 206–217.

De Vos P, Hanck C, Neisingh M, Prak D, Groen H, Faas MM. (2015) Weight gain in freshman college students and perceived health. Preventive Medicine Reports 229–234/dx.doi.org/10.1016/j.pmedr.2015.03.008

Bermudez-Brito M, Sahasrabudhe NM, Rösch C, Schols HA, Faas MM, De Vos P. (2015) The impact of dietary fibers on dendritic cell responses in vitro is dependent on the differential effects of the fibers on intestinal epithelial cells. Mol. Nutr. Food Res. doi 10.1002/mnfr.201400811

Sovran B, Loonen LMP, Lu P, Hugenholtz F, Belzer C, Stolte EH, Van Boekschoten M, Van Baarlen P, Kleerebezem M, De Vos P, Dekker J, Renes IB, Wells JM. (2015) IL-22-STAT3 Pathway Plays a Key Role in the Maintenance of Ileal Homeostasis in Mice Lacking Secreted Mucus Barrier. In flamm Bowel Dis. 2015;21:531–542

Vogt L, Meyer D, Pullens G, Faas MM, Smelt MJ, Venema K, Ramasamy U, Schols HA, De Vos P. (2014) Immunological properties of Inulin-type Fructans. Critical Reviews in Food Science and Nutrition. 55:414–436

Vogt LM, Meyer D, Pullens G, Faas MM, Venema K, Ramasamy U, Schols HA and De Vos P. (2014) Toll-like receptor 2 activation by b2 ->1-fructans protects barrier function of T84 human intestinal epithelial cells in a chain length–dependent manner1,2. The Journal of Nutrition doi: 10.3945/jn.114.191643

Bokhorst-van de Veen H van, Smelt MJ, Wels M, Hijum SAFT van, De Vos P, Kleerebezem M and Bron PA. (2013) Genotypic adaptations associated with prolonged persistence of Lactobacillus plantarum in the murine digestive tract. Biotechnology-Journal. 8,:895–904. doi 10.1002/biot.201200259

Vogt L, Ramasamy U, Meyer D, Pullens G, Venema K, et al. (2013) Immune Modulation by Different Types of b2R1-Fructans Is Toll-Like Receptor Dependent. PLoS ONE. 8(7): e68367. doi:10.1371/journal.pone.0068367

Smelt MJ, De Haan BJ, Bron PA, Van Swam I, Meijerink M, et al. (2013) Probiotics Can Generate FoxP3 T-Cell Responses in the Small Intestine and Simultaneously Inducing CD4 and CD8 T Cell Activation in the Large Intestine. PLoS ONE. 8(7): e68952. doi:10.1371/journal.pone.0068952

Smelt MJ, de Haan BJ, Bron PA, Van Swam I, Meijerink M, et al. (2013) The Impact of Lactobacillus plantarum WCFS1 Teichoic Acid D-Alanylation on the Generation of Effector and Regulatory T-cells in Healthy Mice. PLoS ONE. 8(4): e63099. doi:10.1371/journal.pone.0063099

Remus DM, Bongers RS, Meijerink M, Fusetti F, Poolman B, De Vos P, Wells JM, Kleerebezem M, Bron PA. (2013)The impact of Lactobacillus plantarum sortase on target-protein sorting, gastrointestinal persistence, and host immune response modulation. Journal of Bacteriology. Feb;195(3):502-9. doi: 10.1128/JB.01321-12.

Smelt MJ, De Haan BJ, Bron PA, Van Swam I, Meijerink M, Wells JW, Faas MM, De Vos P.(2013) L. plantarum, L. salivarius, and L. lactis attenuate Th2 responses and increase Treg frequencies in healthy mice in a strain dependent manner. PLoS ONE. 7(10): e47244. doi:10.1371/journal.pone.0047244

Van Beek AA, Knol EF, de Vos P, Smelt MJ, Savelkoul HFJ, van Neerven RJJ.(2013) Recent developments in basophil research: Do basophils initiate and perpetuate Th2 responses? International Archives of Allergy and Immunology. 2013;160:7-17

Meijerink M, van Hemert S, Taverne N, Wels M, de Vos P, Bron P, Savelkoul H, van Bilsen J, Kleerebezem M, Wells J. (2010) Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization. PlosOne. 13: 5 (5) : e10632

De Vos P, Faas MM, Spasojevic M, Sikkema J. (2010) Encapsulation for preservation of functionality and targeted delivery of bioactive food components. International Dairy Journal. 10: 292-302  

Meijer K, De Vos P, Priebe MG. (2010) Butyrate and other short chain fatty acids as modulators of immunity: what relevance for health? Current Opinion in Clinical Nutrition & Metabolic Care. 13(6):715-21

Van Hemert S, Meijerink M, Molenaar D, Bron PA, De Vos P, Kleerebezem M, Wells JM, Marco ML. (2010) Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells. BMC Microbiol. 10:293:1-13