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PIL on Tuesday, January 14th

When:Tu 14-01-2020 12:00 - 13:00
Where:3111-0105 ADL2

‚ÄčThe first PIL of 2020 will be held on Tuesday, January 14th at 12 midday in 3111-0105, ADL2 with a lunch afterwards in the catering area of building 3219 (open area behind the ground floor canteen).
This PILwill be given by Jeffrey Buter from the group of Synthetic Organic Chemistry of the Stratingh Institute for Chemistry.

Does Mycobacterium tuberculosis defend itself from host immune responses with a potential antimalarial drug?

Killing 1.6 million people every year, Mycobacterium tuberculosis(Mtb) is the world's most deadly infectious disease. Furthermore, Mtbis estimated to have infected 1.7 billion people worldwide. The residence of Mtbinside its human host can last for decades in which Mtbsurvives inside individual immune cells (macrophages). Whereas macrophages normally digest foreign invaders (e.g. fungi, bacteria, viruses) using acid and hydrolytic enzymes, Mtbblocks acidic digestion and parasites these macrophages where it is protected from further immune responses. Till recently the molecular mechanism by which Mtbevades acid digestion inside macrophages was unknown.

In this lecture I will discuss 7 years of research into understanding the survival mechanism of Mtb inside macrophages. The ‘star’ of the lecture is a novel, small molecule, natural product named 1-tuberculosinyladenosine (1-TbAd). I will discuss the discovery, chemical synthesis, potential as a biomarker, and the biological role of this intriguing molecule.
The dates and locations of the PILin 2019/2020 are as follows:
Tuesday, January 14th: 3111.0105, ADL2 - Jeffrey Buter
Tuesday, February 11th: 3215-0126 - Jelmer Sjollema
Tuesday, March 10th: Boeringzaal - Fransien van Dijk
Tuesday, April 14th: Boeringzaal - Geert van den Bogaart
Tuesday, May 12th: Boeringzaal -  speaker to be announced
Tuesday, June 9th: Pharmacy Day  

You are all more than welcome to attend the PIL. The PIL committee hopes that you will come in great numbers.