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PIL on Tuesday, November10th

When:Tu 10-11-2020 12:00 - 13:00

​​The second PIL of 2020/2021 will take place online, via google meet, tomorrow, Tuesday, November 10th at 12 noon. The speaker is our own Kristina Haslinger from the group of Chemical and Pharmaceutical Biology. The title of her presentation is:

Needle in a haystack - Selecting the right enzymes for engineered natural product biosynthesis

Natural products found in plants, fungi and bacteria play important roles in human health and lifestyle. They are used as food preservatives, dietary supplements, ingredients in cosmetics, and drugs. However, low natural abundance or difficulty of extraction often make these products rare and expensive. Next to chemical synthesis, biological engineering offers attractive strategies to overcome these challenges. Biological engineering heavily relies on the understanding of the underlying biosynthetic pathways and enzymes involved, and has profited greatly from the increasing number of sequenced genomes. However, identifying enzymes with the intended substrate and product range within this large set of sequenced genomes remains a challenge.

This talk will highlight one example of a screening strategy recently developed to identify novel oxygen-directed methyltransferases and the application of these new enzymes in an Escherichia coli microbial cell factory producing ferulic acid. Furthermore, it will provide a perspective for future directions in the discovery and selection of enzymes for the engineering of microbial cell factories for natural products.

The link to this PIL via Google Meet is:

Alternatively, you can send me an email and I can add you to the list of participants.

The dates of the other PIL's are as follows:


Tuesday, November 10th - Kristina Haslinger

Tuesday, December 8th - Ben Giepmans


Tuesday, January 12th - Barbro Melgert

Tuesday, February 9th - Oscar Kuipers

Tuesday, March 9th - Sandy Schmidt

Tuesday, April 13th - to be announced

Tuesday, May 11th - to be announced

Tuesday, June 8th, Pharmacy Day