PIL on Tuesday 11th September
|When:||Tu 11-09-2018 12:00 - 13:00|
This PILwill be given by Jan Maarten van Dijl, professor of Medical Microbiology, UMCG.
Francisco Romero Pastrana1, Mafalda Bispo1, Andrea Anaya Sanchez1, Elisa Raineri1, Marina López-Álvarez1, Marjolein Heuker1, John Thompson2, Daniel Thorek2, Nicholas Bernthal3, Kevin Francis4, Girbe Buist4, Gooitzen van Dam4, Marleen van Oosten1, Lloyd Miller2, Jan Maarten van Dijl1
1Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 2Johns Hopkins University School of Medicine, Baltimore, USA, 3University of California, Los Angeles Medical Center, Santa Monica, USA, 4PerkinElmer, Alameda, USA
Staphylococcus aureus infections are a major threat in healthcare, requiring adequate early-stage diagnosis and treatment. This calls for novel diagnostic and therapeutic tools that allow noninvasive in vivo detection and elimination of staphylococci. To develop next-generation diagnostics, we have performed preclinical studies with tracers based on the clinically applied antibiotic vancomycin and a novel fully-human monoclonal antibody (1D9). Using a human post-mortem implant model and in vivo murine infection models, preclinical feasibility for direct optical imaging of in vivo S. aureusinfections was demonstrated for vancomycin and 1D9 labeled with the near-infrared fluorophore IRDye800CW. Additionally, 89Zirconium-labeled 1D9 could be used for positron emission tomography imaging of a murine S. aureus infection model. To assess the feasibility of a ‘theragnostic’ approach, we have labeled 1D9 with the photo-activatable IRDye700DX, showing that this tracer can potentially be used to treat S. aureus infections. We conclude that our findings pave the way towards clinical implementation of targeted imaging and antimicrobial photodynamic therapy of staphylococcal infections using labeled antibiotics or human monoclonal antibodies.
The dates and locations of the PILin 2018/2019 are as follows:
Tuesday, October 9th: Boeringzaal - Barbro Melgert
Tuesday, November 13th: Boeringzaal - Victor Guryev
Tuesday, December 11th: Boeringzaal - to be announced
Tuesday, January 15th: 3215-0126 - to be announced
Tuesday, February 12th: to be announced
Tuesday, March 12th: to be announced
Tuesday, April 9th: to be announced
Tuesday, May 14th: Anna Salvati
Tuesday, June 11th: Pharmacy Day
You are all more than welcome to attend the PIL. The PIL committee hopes that you will come in great numbers.
Best regards, also on behalf of the PIL committee,