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PIL on Tuesday 9th January

When:Tu 09-01-2018 12:00 - 13:00
Where:3215-0126
Dear colleagues and students,
The fifth PIL of year 2017/2018 will be held on Tuesday, January 9th at 12 midday in 3215-0126 with a lunch afterwards in the catering area opposite the Keuningzaal.
This PIL will be given by Floriaan Schmidt of the Pharmacotherapy, -Epidemiology and -Economics group.
The title of his presentation is:
Mendelian randomization for biomarker and drug target validation

Mendelian randomization (MR) studies use natural randomly allocated variation in gene sequences associated with exposures of biomedical interest to explore their causal relationship to disease. Traditionally, MR studies have focussed on the causal effect of a biomarker for a disease of interest by utilizing multiple variants from across the genome, termed MR for biomarker validation.

Biomarkers of biomedical interest include mRNA expression level, protein or metabolite concentration, and physiological variables such as blood pressure. Among these, proteins are exposures of particular interest because they comprise the targets of most drug treatments. Since proteins are encoded by specific genes, variants within those genes (acting in cis) enable a specific category of MR analysis aimed at drug target validation.

In my lecture I will argue that both types of MR analyses can complement the current drug development via early phase incorporation of human subject based evidence.

The dates and locations of the PIL in 2018 are as follows:
Tuesday, 9 januari: 3215-0126 - Floriaan Schmidt
Tuesday, 13 februari: 3212-0217 - Peter Horvatovich
Tuesday, 13 maart: 3212-0217 - Gert Salentijn
Tuesday, 10 april: 3212-0217 - Katja Taxis
Tuesday, 8 mei: 3214-0081 - Shabnam Shaabani
Tuesday, 12 juni (Pharmacy Day):
You are all more than welcome to attend the PIL. The PIL committee hopes that you will come in great numbers.
Best regards, also on behalf of the PIL committee