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MCB Seminar - Dr. Mattia Bramini

When:We 01-11-2017 10:00 - 11:00
Where:Building 3211-S42B

The Medicinal Chemistry & Bioanalysis (MCB) Program GUIDE – Graduate School for Drug Exploration

SEMINAR

Dr. Mattia Bramini

Center for Synaptic Neuroscience and Technologies & Graphene Labs, Istituto Italiano di Tecnologia, Genova, Italy

Neuronal-Nanotechnology: an overview of graphene biomedical applications in the central nervous system

For more information: christoffer.aberg@rug.nl (Christoffer Åberg)

Neuronal-Nanotechnology: an overview of graphene biomedical applications in the central nervous system

Dr. Mattia Bramini

The emerging interest toward applying nanomaterials for drug and gene delivery, biomedical imaging and diagnostic biosensors within the central nervous system (CNS) prompted neuroscientists to focus on the effects of the interaction of nanostructures in contact with primary neural cells. We are currently pursuing various lines of research inside the Graphene Flagship European project, focusing our attention on graphene-based material interactions with primary neurons, glial cells and in vitro blood-brain barrier (BBB) models. We are characterizing the molecular mechanisms of graphene nanosheet internalization into cells together with the possible inflammatory responses, and the possibility of using both 2D and 3D graphene-based supports as biocompatible scaffolds for biomedical applications. The final aim is to exploit the conductive properties of graphene to modulate and control the activity of neural networks grown in strict contact with such structures (i.e. for artificial retina approach). Moreover, we investigate the biology of BBB when in contact with graphene by reconstitution in vitro of the tripartite endothelium/glial/neuronal interface, integrating experimental tests with Molecular Dynamics simulations. Recently, we also challenged the CNS with other "nanotools" to potentially target specific neural disorders, ranging from small molecules to few nanometre composite particles.

In this seminar, the neuro-nanotechnology activities carried out in our lab will be presented in detail, focusing on both nanomedicine and nanosafety features.