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MCB Seminar - Prof. Carlos Camacho - University of Pittsburgh, USA

When:We 04-05-2016 15:00 - 16:00
Where:Building 3215‐0165

The Medicinal Chemistry & Bioanalysis (MCB) Program GUIDE – Graduate School for Drug Exploration


Prof. Carlos Camacho

Department of Computational Biology

School of Medicine, University of Pittsburgh USA

What does it take to modulate regulatory proteins?

A key challenge modulating regulatory proteins has been to understand their intrinsic flexibility. In this presentation, the key role that flexibility plays in regulation will be explained. As an example, it will be discussed in detail how the intrinsic flexibility of PD‐1 is modulated by its cognate ligands PD‐L1 and PD‐L2.