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Lecture Prof. John Scott

When:We 03-10-2018 09:30 - 10:30
Where:Keuningzaal, Building 3214.0063

John Scott is head of the Division Pharmacology at the University of Washington School of Medicine, Seattle. He is also entitled as Edwin G. Krebs-Hilma Speights Professor. He received his B.Sc. (Hons) degree from Herriot-Watt University, Edinburgh, and his Ph.D. degree from the University of Aberdeen. He did postdoctoral research on protein kinase inhibitors in the laboratory of Edwin Krebs at the University of Washington. Edwin Krebs received the Nobel Prize for Physiology in Medicine in 1992. John Scott joined the faculty of the University of California, Irvine before moving to the Vollum Institute at the Oregon Health & Sciences University, Portland.

John Scott is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates. His research has let to novel insights in the field of signaling in space and time. He made major contributions to the development of novel therapeutics to treat heart failure and diabetes. Currently he drives the field to concept of using the family of anchoring proteins to specifically target drug to subcellular locations to improve personalized medicine and drug targeting strategies. The field of protein-protein interactions is rapidly developing, getting thereby more and more into the focus of national and international meetings. Here it is worthwhile to mention the symposium organized on the Dutch Medicine Days 2017 in the framework of the Prix Galien 2017, "Peptides and proteins are key", and the CHAIN Meeting 2017, "Chemistry as Innovating Science". John spans the broad area of cell signaling, biochemistry, physiology and pharmacology.

Dr. Scott is a fellow of the Royal Society, London, and was recently elected a fellow of the Royal Society of Edinburgh, fellow of the American Association for the Advancement of Science, and fellow of the Norwegian Academy of Science and Letters. He received the Award in Pharmacology, American Society for Pharmacology and Experimental Therapeutics, the Ernst Oppenheimer Award, Endocrine Society, the William C. Rose Award, American Society for Biochemistry and Molecular Biology, the Medical Research Foundation of Oregon Discovery Award and the D. Harold Copp Award, University of British Columbia. He current h-index is about 102 (Google Scholar), and about 33109 citations.

Host: Professor Martina Schmidt, Head Molecular Pharmacology, GRIP, m.schmidt@rug.nl

Selected literature:

Wong, W. and Scott, J.D. (2004). AKAP signalling complexes: focal points in space and time. Nature

Reviews Cell Biology 5:959-970.

Scott, J.D. and Pawson, T. (2009). Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart. Science 326:1220-1224. PMCID: PMC3041271.

Langeberg, L.K. and Scott, J.D. (2015) Signalling scaffolds and local organization of cellular behavior. Nature Reviews Molecular Cell Biology. 16:232-244. PMCID: PMC4722875