Nanostructured surfaces and (bio)functional materials
DNA has developed into one of the most frequently utilized building blocks in nanoscience due to its well-defined selfrecognition properties. While over the years many researchers in the field of DNA nanotechnology have realized more and more complex and esthetic nanoobjects, the researchers of the Advanced Materials program focused on realizing complex functions and chemical transformations with this bionanomaterial. In 2008, we were the first to employ soft matter DNA nanoparticles for targeted drug delivery in vitro and in the meantime, we have successfully realized the first in vivo applications of such carrier systems in the field of ophthalmology. When combining DNA with conjugated polymers to disperse carbon nanotubes we were able to specifically place the semiconducting tubes within nanoelectronic devices in a concerted effort involving five groups within the Zernike Institute NRC. The intercalation of ligands and transition metals into DNA double strands enabled us to be the first chemists exploiting the DNA helix as source of chirality for asymmetric catalysis. When binding structurally complex molecules to an aptamer, the nucleic acid acts as shield to allow the site-specific chemical modification of natural products with very high regioselectivity but without cumbersome multi-step synthesis. In summary, several novel technology platforms involving DNA materials to deal with future complex environments have been developed through the efforts of groups within the theme.
|Last modified:||31 January 2017 10.50 p.m.|