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Research GBB Electron cryo-Microscopy

Publications

Garaeva AA, Oostergetel GT, Ga C, Guskov A†, Paulino C† and Slotboom DJ†, Cryo-EM structure of the human neutral amino acid transporter ASCT2. Nat. Struc. Mol. Biol. (2018); doi:10.1038/s41594- 018-0076-y
https://www.nature.com/articles/s41594-018-0076-y#article-info

Deneka D*, Sawicka M*, Lam AKM, Paulino C and and Dutzler R, Structure of a volume-regulated anion channel of the LRRC8 family. Nature (2018);
doi:10.1038/s41586-018-0134-y
https://www.nature.com/articles/s41586-018-0134-y?spMailingID=56634952&spUserID=MzE2MDc5MDQ3NzU4S0&spJobID=1402572178&spReportId=MTQwMjU3MjE3OAS2#article-info


Paulino C , Kalienkova V, Lam AKM, Neldner Y and Dutzler R, Activation mechanism of the chloride channel TMEM16A revealed by cryo-EM. Nature (2017); doi:10.1038/nature24652

Paulino C , Neldner Y, Lam AKM, Kalienkova V, Brunner JD, Schenck S and Dutzler R, Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. eLife (2017, selected for an eLife Insights); doi: 10.7554/eLife.26232

Paulino C* , Wöhlert D*, Kapotova E, Yildiz Ö and Kühlbrandt W, Structure and transport mechanism of the archaeal Na+/H+ antiporter MjNhaP1. eLife (2014); doi: 10.7554/eLife.03583

Paulino C and Kühlbrandt W, pH and sodium-induced changes in a sodium/proton antiporter. eLife (2014); doi: 10.7554/eLife.01412

Calinescu O, Paulino C, Kühlbrandt W, Fendler K, Keeping it simple – transport mechanism and pH regulation in Na+/H+ exchangers. J Biol Chem (2014); doi: 10.1074/jbc.M113.542993

Goswami P*, Paulino C*, Hizlan D, Vonck J, Yildiz Ö, Kühlbrandt W, Structure of the archaeal Na+/H+ antiporter NhaP1 and functional role of transmembrane helix 1. EMBO J (2011); doi: 10.1038/emboj.2010.321

PRESS

Scientists reveal structure of amino acid transporter involved in cancer
https://www.eurekalert.org/pub_releases/2018-06/uog-srs060518.php

Protein structure could unlock new treatments for cystic fibrosis. December 13 2017
https://www.media.uzh.ch/en/Press-Releases/2017/Chloride-channel-cystic-fibrosis.html


Bringing the resolution revolution to Groningen - New electron microscope resolves structure of proteins. Science LinX, 12 December 2017
https://www.rug.nl/sciencelinx/nieuws/2017/12/20171312_paulino

Kuné's Kijk: de Cryo-elektronenmicroscoop. Pictogram Vol 19, Nr. 4 (2017)
https://ugp.rug.nl/pictogram/article/view/30977/28288

Zoveel detail zagen we nog nooit - Nobelprijs voor Scheikunde. NRC.nl, October 5 2017
https://www.nrc.nl/nieuws/2017/10/05/zoveel-detail-zagen-we-nog-nooit-13336458-a1575991

Eindelijk kunnen we écht binnenin de cel kijken. NRC.nl, June 9 2017
https://www.nrc.nl/nieuws/2017/06/09/eindelijk-kunnen-we-echt-in-cel-kijken-11001619-a1562384

Last modified:18 June 2018 1.52 p.m.