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About us Faculty of Science and Engineering Our Research GRIP Analytical Biochemistry MCB 2014

Program

August 25

Session 1

Arrival and Registration

9:00 – 09:45

Opening

9:45 – 10:00

Keynote 1

Chryssostomos Chatgilialoglu (Institute of Nanoscience and Nanotechnology, National Center of Scientific Research "Demokritos", Athens, Greece)

10:00 – 10:30

Biomimetic models of radical stress and related biomarkers

Frank Dekker (Department of Therapeutic Gene Modulation)

10.30 - 10.50

Novel chemical strategies for inhibition and detection of lipoxygenases in inflammation

Creina Slator (Dublin City University, School of Chemical Sciences and National Institute for Cellular Biotechnology, Glasnevin, Dublin, Ireland)

10:50 – 11:05

Di‐nuclear copper(II) complexes as chemotherapeutic leads

Thea van den Bosch (Department of Therapeutic Gene Modulation)

11:05 – 11:20

Proteomic analysis of changes in protein acetylation in inflammation

Coffee Break

11:20 – 11:40

Keynote 2

Gianni Sava (Callerio Foundation, Trieste, Italy)

11:40 – 12:10

The complexity of metastasis biology must drive anticancer drug development

Angela Casini (Department of Pharmacokinetics, Toxicology and Targeting)

12:10 – 12:30

A golden future in medicinal inorganic chemistry: the promise of anticancer gold‐based compounds

Andreia de Almeida (Department of Pharmacokinetics, Toxicology and Targeting)

12:30 – 12:45

In silico approaches to identify Aquaporin inhibitors

Milon Mondal (Stratingh Institute for Chemistry, University of Groningen)

12:45 – 13:00

De novo structure‐based design of novel inhibitors of the aspartic protease endothiapepsin exploiting dynamic combinatorial chemistry

Lunch/Posters

13:00 – 14:30


Session 2

Keynote 3

Lieven Meerpoel (Johnson & Johnson Pharmaceutical Research & Development, Beerse, Belgium)

14:30 – 15:00

Innovation through external collaboration

Alexander Dömling (Department of Drug Design)

15:00 – 15:20

A novel computational platform linking drug discovery with fast and efficient chemistry pathways

Tryfon Zarganes‐Tzitzikas (Department of Drug Design)

15:20 – 15:35

The first and best‐in‐class broad range influenza small molecules targeting the hemagglutinin sialic acid binding pocket

André Heeres (Syncom, Groningen, The Netherlands)

15:35 – 15:50

Design and synthesis of multiple ligands for the treatment of motor and cognitive symptoms of Parkinson’s disease

Coffee Break

15:50 – 16:10

Keynote 4

Alain Van Dorsselaer (Institut Pluridisciplinaire Hubert Curien, Strasbourg, France)

16:10 – 16:40

Are today’s proteomic analysis performances good enough?

Rainer Bischoff (Department of Analytical Biochemistry)

16:40 – 17:00

Biomarker discovery and validation – the long road to travel

Alexander Boichenko (Department of Analytical Biochemistry)

17:00 – 17:15

iTRAQ‐based profiling and label‐free quantification revealed a panel of regulated proteins in cervical intraepithelial neoplasia and cervical cancer serum

Karin Wolters (Department of Medical Systems Biology, University Medical Centre Groningen)

17:15 – 17:30

Targeted proteomics as a tool to study biological pathways and processes

Symposium Dinner

19:00

Restaurant WEEVA ‐ sinds 1871 / Martini Hotel

Gedempte Zuiderdiep 8‐10

9711 HG Groningen

August 26

Session 3

Keynote 5

Lennart Martens (Department of Medical Protein Research, Ghent University and VIB, Ghent, Belgium)

9:00 – 09:30

Tomb raider: the fruitful exploration of proteomics data graveyards

Péter Horvatovich (Department of Analytical Biochemistry)

9:30 – 09:50

Practical aspects of LC‐MS data preprocessing and statistical analysis

Jaap Wieling (QPS Netherlands BV, Groningen, The Netherlands)

9:50 –10:05

Bioanalysis by elemental mass spectrometry: an overview of 10 years of ICPMS and LC‐ICP‐MS in clinical and preclinical R&D

Laurent Rieux (Antec BV, Zoeterwoude, The Netherlands)

10:05 –10:20

Enhanced pharmaceutical stability testing using on‐line electrochemical reactions up‐front MS

Coffee Break

10:20 –10:40

Keynote 6

Ullrich Jahn (Institute of Organic Chemistry and Biochemistry ASCR, Prague, Czech Republic)

10:40 –11:10

New radical avenues to biologically active natural products and their analogs

Gerrit Poelarends (Department of Pharmaceutical Biology)

11:10 – 11:30

Chemo‐enzymatic synthesis of chiral building blocks for pharmaceuticals

Edzard Geertsema (Department of Pharmaceutical Biology

11:30 – 11:45

Biocatalytic Michael‐type additions yielding enantioenriched precursors of GABA‐based pharmaceuticals

Martin Witte (Stratingh Institute for Chemistry, University of Groningen)

11:45 – 12:00

Targeted‐diazotransfer reagents to site‐selectively introduce azides on proteins

Lunch/Posters

12:00 – 13:00


Session 4

Keynote 7

Wilhelm Huck (Department of Physical Organic Chemistry, Radboud University, Nijmegen, The Netherlands)

13:00 – 13:30

Role of mechanical cues of the extracellular matrix in regulating stem cell fate

Sabeth Verpoorte (Department of Pharmaceutical Analysis)

13:30 – 13:50

Microfluidics in a drug development environment

Matthew Groves (Department of Drug Design)

13:50 – 14:05

Macromolecular self-assembly in living organisms (MaSALO) as a unique tool in drug discovery

Pieter Oomen (Department of Pharmaceutical Analysis)

14:05 – 14:20

Incorporation of sensors into microfluidic tissue culture systems for improved control of incubation conditions

Loes Kistemaker (Department of Molecular Pharmacology, University of Groningen)

14:20 14:40

Precision cut lung slices as a model for efficacy analysis

Closing Remarks

14:40 – 14:50

Laatst gewijzigd:13 augustus 2014 08:24