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Informatie over BSc Biology: major Biomedical Sciences
Hieronder staan het programma en de vakomschrijvingen van BSc Biology: major Biomedical Sciences Klik op de naam van een vak in een schema om naar de omschrijving te gaan.
| » Jaar 1 | |||||||
| Periode | Type | Code | Naam | Taal | ECTS | Uren | |
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| semester I a | verplicht | WBBY001-05 | Basic Cell and Molecular Biology | Engels | 5 | ||
| verplicht | WBBY005-05 | Genetics, Ecology and Evolution | Engels | 5 | |||
| verplicht | WBBY011-05 | Physiology | Engels | 5 | |||
| semester I b | verplicht | WBBY014-05 | Biostatistics 1 | Engels | 5 | ||
| verplicht | WBBY017-02 | First Year Symposium | Engels | 2 | |||
| verplicht | WBBY021-03 | Lab Course | Engels | 3 | |||
| verplicht | WBBY022-05 | Microbiology | Engels | 5 | |||
| semester II a | verplicht | WBBY026-05 | Behavioural Neurosciences | Engels | 5 | ||
| verplicht | WBBY033-05 | Cell Biology and Immunology | Engels | 5 | |||
| verplicht | WBBY047-05 | Molecules of Life | Engels | 5 | |||
| semester II b | verplicht | WBBY058-05 | Metabolism | Engels | 5 | ||
| verplicht | WBBY066-02 | Research Skills in Life Sciences 1 | Engels | 2 | |||
| verplicht | WBBY067-03 | Research Skills in Life Sciences 2 | Engels | 3 | |||
| verplicht | WBBY068-05 | Research Skills in Life Sciences 3 | Engels | 5 | |||
| Opmerkingen | PLEASE NOTE | ||||||
| » Jaar 2 | |||||||
| Periode | Type | Code | Naam | Taal | ECTS | Uren | |
| semester I a | verplicht | WBBY002-05 | Bioinformatics | Engels | 5 | ||
| verplicht | WBBY008-05 | Molecular Genetics | Engels | 5 | |||
| keuzegroep A | WBBY006-05 | Integrative Neuroscience | Engels | 5 | |||
| keuzegroep A | WBBY007-05 | Medical Structural Biology | Engels | 5 | |||
| semester I b | verplicht | WBBY019-05 | Host-microbe Interactions | Engels | 5 | ||
| verplicht | WBBY020-05 | Immunology | Engels | 5 | |||
| verplicht | WBBY024-05 | Modelling Life | Engels | 5 | |||
| semester II a | keuze | WBBY030-05 | Biology of Cancer | Engels | 5 | ||
| keuze | WBBY035-05 | Endocrinology | Engels | 5 | |||
| keuze | WBBY036-05 | Epigenetics and Gene-editing | Engels | 5 | |||
| keuze | WBBY039-05 | Evolutionary Medicine | Engels | 5 | |||
| keuze | WBBY041-05 | Food and Metabolism | Engels | 5 | |||
| keuze | WBBY042-05 | Human Genetics and Genomics | Engels | 5 | |||
| keuze | WBBY043-05 | Immunology and Disease | Engels | 5 | |||
| keuze | WBBY045-05 | Medical Cell Biology | Engels | 5 | |||
| keuze | WBBY059-05 | Microbes and Infection | Engels | 5 | |||
| semester II b | verplicht | WBBY049-05 | Biology & Society: Ethical and Professional Aspects | Engels | 5 | ||
| keuze | WBBY027-05 | Big Data in Human Disease | Engels | 5 | |||
| keuze | WBBY050-05 | Bio-organic Chemistry | Engels | 5 | |||
| keuze | WBBY051-05 | Cardiovascular Disease | Engels | 5 | |||
| keuze | WBBY055-05 | Hematopoietic Stem Cells, Differentiation and Development | Engels | 5 | |||
| keuze | WBBY057-05 | Medical Physiology | Engels | 5 | |||
| keuze | WBBY061-05 | Molecular Research in Human Disease | Engels | 5 | |||
| keuze | WBBY062-05 | Neurobiology of Ageing | Engels | 5 | |||
| Opmerkingen | PLEASE NOTE | ||||||
| » Jaar 3 | |||||||
| Periode | Type | Code | Naam | Taal | ECTS | Uren | |
| semester I b | keuze* | WBBY023-05 | Minor congress (Life Sciences) | Engels | 5 | ||
| semester II | verplicht | WBBY901-05 | Bachelorscriptie levenswetenschappen | Engels | 5 | ||
| ^verplicht | WBBY902-10 | Research Project Biomedical Sciences | Engels | 10 | |||
| semester II a | keuze | WBBE015-05 | Regenerative medicine | Engels | 5 | ||
| semester II b | keuze | WBBY076-05 | Competences and Professionalization in Biology | Engels | 5 | ||
| Opmerkingen | ^ BMS students can follow only one research project. Students have to choose between period 2a or 2b.
In year 3 semester 2, students have to enroll for electives next to following the compulsory Bachelor Thesis and Research Project. These electives should be chosen from course units in year 2 of the major Biomedical Sciences. An exception is the course "Regenerative Medicine" which is not an elective in year 2, but which can be chosen by BMS students in year 3. For more information, please check the Student Portal. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification. | ||||||
| » Pre-master Biomedical Sciences | |||||||
| Periode | Type | Code | Naam | Taal | ECTS | Uren | |
| semester I b | verplicht | WBBY077-05 | Neurobiology | Engels | 5 | ||
| 1 | Bachelorscriptie levenswetenschappen | WBBY901-05 | |||||||||||||||||||||||||||
| De bachelorscriptie bestaat in het geval van een onderzoek uit een literatuuronderzoek binnen het onderzoeksgebied van de gevolgde major. De scriptie wordt geschreven in combinatie met het bacheloronderzoek en sluit hier inhoudelijk bij aan. De student dient onder begeleiding van een docent: - op een wetenschappelijk verantwoorde manier een vraagstelling te formuleren - literatuuronderzoek te verrichten - bevindingen en conclusies te presenteren door middel van een wetenschappelijke tekst - een beargumenteerd standpunt of visie in te nemen en deze te verantwoorden De bachelorscriptie bestaat bij een ontwerpopdracht uit het uitvoeren van de analysefase: - probleemdefinitie - doel van het product - ontwerpopdracht, inclusief afbakening - eisenpakket - functieanalyse Ook moeten bevindingen en conclusies worden gepresenteerd door middel van een rapport De omvang van de scriptie is in beide gevallen 10-15 pp oftewel 4500 – 6500 woorden. Meer informatie is te vinden op Nestor en in de Richtlijnen voor Bachelorscriptie en Bacheloronderzoek Biologie en LST | |||||||||||||||||||||||||||||
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| 2 | Basic Cell and Molecular Biology | WBBY001-05 | |||||||||||||||||||||||||||
| During the course the basic processes of cell biology and molecular biology will be addressed. The molecular biology lectures includebtopics like molecular composition of the cell, DNA structure and replication, RNA and transcription, protein synthesis, and basic recombinant DNA techniques. The cell biology lectures include topics like cell membranes, cell compartments, vesicle transport inside the cell, cell cycle, and mitosis and meiosis. | |||||||||||||||||||||||||||||
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| 3 | Behavioural Neurosciences | WBBY026-05 | |||||||||||||||||||||||||||
| Lectures: Basic course unit which covers the structure of the central nervous system, the fundamental connection between the brain and behavior in relation to, learning and memory, sleep, sexual differentiation, sensory systems and the timing of behavior. The course also covers the basic principles of common central nervous system disorders. Practicals: Anatomy of the healthy human brain and brain of Alzheimer patients (NB: no dissection practical), analysis of learning behavior in animals, pharmacological manipulation of learning behavior, personality tests in humans related to lateralization of the brain. Knowledge: Students will understand and be able to reproduce the basic principles of the structure of the brain, the basic principles of behavior, and will be able to make functional relations between brain structures and behavioral processes. Students will also be trained to reproduce basic brain and behavioral principles related to the working of the following sensory systems: the visual system, the ear, and the vestibular system. The students will also be able to recognize some common behavioral and central nervous system disorders. Skills and Training: Students will be trained in analyzing data and writing short summaries. End terms knowledge: To understand and reproduce the basic principles of the anatomy and function of the brain. To reproduce the functional relationship between some of the sensory systems, behavior, and brain structures. | |||||||||||||||||||||||||||||
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| 4 | Big Data in Human Disease | WBBY027-05 | |||||||||||||||||||||||||||
| The development of high-throughput technologies has advanced biomedical research at an unprecedented speed. Life scientists are starting to generate and have an access to massive data sets. It is a big challenge for biologists to handle and process big data, conduct analysis and interpret results. For the next-generation biologists and biomedical researcher, big data analysis has become critically important. This course is designed to fit the trend of big data science in the biological and medical field and to meet the need to develop students’ skills in “big data science”. | |||||||||||||||||||||||||||||
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| 5 | Bioinformatics | WBBY002-05 | |||||||||||||||||||||||||||
| This course presents an introduction to bioinformatics, to bioinformatics tools and databases. The databases used in the course are those in which genomes, genes, mRNAs, proteins, protein patterns, gene variants and gene/protein expression are stored. The bioinformatics tools will be used to perform sequence alignments, create phylogenetic trees, predict genes/exons/introns, meta-genomics, and to model biological processes on the basis of -omics datasets. Furthermore, databases will be used to study genetic variation and complex diseases. | |||||||||||||||||||||||||||||
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| 6 | Biology & Society: Ethical and Professional Aspects | WBBY049-05 | |||||||||||||||||||||||||||
| The course allows the students to develop a critical, responsible and professional attitude towards their own role as a scientist and the consequences of their actions in a broader societal context. Students will be engaged into thinking about scientific and innovative practices that can address the global challenges of our time in a collaborative, ethical and sustainable way. To understand the relations between biology and society a number of basic elements from ethics, philosophy of science, innovation and policy making will be introduced. Students will practice applying these elements in (the assessment of) debates, controversies and cases related to the large societal challenges of our time, including themes such as responsible research and innovation, sustainability, and the role of science, business and policy in this. To demonstrate these aspects, an excursion to a company or policy organization is also part of this course. This course is examined with an exam (multiple choice questions and essay question(s)) and a paper that students write in groups of four students. In this paper students need to apply the content of the course to a specific topic at the interface of biology and society. | |||||||||||||||||||||||||||||
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| 7 | Biology of Cancer | WBBY030-05 | |||||||||||||||||||||||||||
| During this course we will discuss in the lectures: carcinogenesis, cancer stem cells, the role of oncogenes and tumor suppressor genes, the large variety of subtypes within hematological and solid tumors, the signaling pathways active in different tumor types, genetic regulation of these molecular pathways (epigenetics, miRNA), DNA damage response, the tumormicroenvironment , the process of metastasis, tumor immunology, therapeutic strategies to inhibit tumor growth, development of cancer drugs, development of clinically relevant cancer models, and clinical cancer research. Each group of 4-5 students will investigate an interesting oncogene or tumor suppressor gene using publicly available databases. Normal function of the gene of interest, its role in cancer, in which cancer type the gene plays a role, which mutations are found in this cancer gene and how we can use this knowledge for treatment strategies. Results are presented during a poster session. | |||||||||||||||||||||||||||||
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| 8 | Bio-organic Chemistry | WBBY050-05 | |||||||||||||||||||||||||||
| The aim of this course is to gain insight in a number of important reactivity principles in Bio-organic Chemistry. A focal point is the understanding and the application of several reaction types that form the basis of cell metabolism, and to get insight in the structure and reactivity of molecules. Function and reactivity of molecules is discussed in the context of the living cell. | |||||||||||||||||||||||||||||
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| 9 | Biostatistics 1 | WBBY014-05 | |||||||||||||||||||||||||||
| The course Biostatistics 1 introduces students to the statistical analysis of biological research data. The course is structured in 11 modules that cover the following topics: descriptive statistics, sources of variation and error propagation, correlation and regression, probability theory, test theory and experimental design, chi-squared tests for goodness-of-fit and independence, confidence intervals, comparisons between two samples, analysis of variance and bayesian statistics. The final module is dedicated to a review and summary of the course, in order to prepare students for the final (written) exam. Each module starts with two lecture hours, followed by one hour study time or a short working group to digest or discuss the material in the course manual. Students then work for four hours on pen-and-paper and computer exercises, where they learn to apply their new knowledge to problems taken from biological research practice. Solutions to a subset of the pen-and-paper and computer exercises have to be handed in at the end of each practical; these are evaluated by the teaching-assistants. Students receive feedback from their teaching assistant at the next practical, as well as worked-out solutions of all exercises. | |||||||||||||||||||||||||||||
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| 10 | Cardiovascular Disease | WBBY051-05 | |||||||||||||||||||||||||||
| During the course, students are introduced to the key mechanisms in the development of the heart and blood vessels as well as basic knowledge on the development of major cardiovascular diseases, e.g. cardiac failure, atherosclerosis, sepsis, and vasculitis. In addition, students will be informed on the basics of (therapeutic) regeneration in the cardiovascular system by stem cells or cell- specific therapy. The course schedule holds lectures in the morning (9.00 – 12.00h) and room for assignments or self-study (both 2-3 days/week) in the afternoon. The assignments consist of research proposals on a cardiovascular disease and the design of a new therapeutic approach. Assignments are supervised by experts in the field. In the first week of the course, the development of heart and blood vessels is discussed. Lecture themes are as follows: Development of the vascular System, Functioning of the vascular system, Development and functioning of the heart, and Regeneration in the cardiovascular system. In the second week of the course, the development and treatment of major cardiovascular diseases are discussed. Lecture themes are as follows: Inflammation in the vasculature: Vasculitis, Diseases of the heart: Acute Myocardial Infarction and Cardiac Failure, Diseases of the blood vessels: Atherosclerosis and vessel remodeling, and Septic shock and multi-organ failure. In the third week, the assignments are submitted and a digital exam will be taken. | |||||||||||||||||||||||||||||
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| 11 | Cell Biology and Immunology | WBBY033-05 | |||||||||||||||||||||||||||
| During the course the basic processes of cell biology and and an introduction in the basic principles and concepts of immunology will be addressed. The cell biology lectures follow up on the course basic cell biology and molecular biology, and include topics like signal transduction, cell-cell communication, cytoskeleton, cell movement, cell cycle, cell death, multicellular development, tissue homeostasis, stem cells and cancer. The immunology lectures start with a short history of immunity after which basic principles of immunity, innate immunity, acquired immunity, immune response pathways to bacteria and virusses, and disorders of the immunesystem will be addressed. The immunology part includes a magistral lecture on dendritic cells, and e-learning assignment on inflammation. | |||||||||||||||||||||||||||||
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| 12 | Competences and Professionalization in Biology | WBBY076-05 | |||||||||||||||||||||||||||
| In this course students will learn how to set up different project forms. In the first week the focus is on academic research projects. Students have to improve a written research project proposal in an interdisciplinary group. This process is supported by (guest) lectures about setting up a consortium, interdisciplinary project management, data management and protection, grant writing and writing a societal paragraph. At the end of the first week, we'll also practice how to apply for a grant for a research project proposal. In the second week we broaden the scope of project work by introducing other types of projects. Here the focus is on societal projects, for example a business or policy project. Now students have to write a project proposal in another interdisciplinary group. This process is supported by (guest) lectures about policy, entrepreneurship and personal development. In the third week the focus is on how to sell your science and society project proposal. We'll do this by playing the academic version of Dragon's Den with 'dragons' who are all expert within interdisciplinary project work. This is supported by (guest) lectures about pitching your project, personal branding and marketing. Assessment of this course is 30% improved written project proposal Research Project, 40% written project proposal Science & Society Project, 30% presentation project proposal Science & Society Project. | |||||||||||||||||||||||||||||
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| 13 | Endocrinology | WBBY035-05 | |||||||||||||||||||||||||||
| The course consist of lectures and writing an essay. In the lectures, we will focus on various endocrine systems and how they influence the individual’s physiology. Endocrine systems that we focus on will amongst others be: • Thyroid and parathyroid • Hormones of the gastrointestinal tract • Hormones of the pancreas • Hormones of the adrenal gland • Endocrinology of reproduction Next to this we will focus on how endocrine systems adapt to different circumstances, such as exercise or stress, but also to pregnancy. Human reproduction will be taught in more detail, since we will focus on the development of the human placenta (the biggest endocrine organ) and we will look into differences in placentas in different animals. The changes in endocrine systems during pregnancy will be discussed as well as the development of male and female sex organs. We will try to schedule 1 or 2 clinical lectures, in which clinicians show endocrinology from the clinical site. Essay: all students write an essay on an endocrine subject. Essays will be written in couples. Students can choose from a list of subjects or bring in their own subject. In the beginning of the course, students can register for a subject via nestor. All essays will be published on the website as an online book. | |||||||||||||||||||||||||||||
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| 14 | Epigenetics and Gene-editing | WBBY036-05 | |||||||||||||||||||||||||||
| Based in part on developments in genomics, both Epigenetics and Gene Editing are rapidly entering the clinical arena. This course will guide the student from understanding basic principles in epigenetics and gene expression regulation, cellular differentiation and dedifferentiation to clinical applications of epigenetic drugs, induced pluripotent stem cells and cellular reprogramming by (CRISPR/Cas-based) gene targeting approaches. From one DNA molecule to numerous cell types: molecular epigenetics Although cells in individual organisms contain the same DNA, different gene expression programs underlie the many different cell identities. Molecular epigenetics marks and mechanisms associated with this process of gene expression control and epigenetic memory will be discussed, as well as opportunities of epigenetics in disease diagnosis and treatment. From one fertilized egg to a complete organism: the example of neurons All organisms arise from one single fertilized egg. This process of differentiation and memory will be explained with a special focus on neuronal differentiation. External stimuli interfering with embryonal development will be discussed as well as examples of (neurodegenerative) diseases associated with epigenetic dysregulation. From one differentiated cell to any other cell type: cellular reprogramming Only three factors are required to dedifferentiate cells to “induced Pluripotent Stem Cells” (iPSCs). From this pluripotent state, cells can be reprogrammed into another cell type. This process and the clinical applications will be discussed. From a diseased cell state to a healthy cell status: gene targeting to correct or compensate for genetic or epigenetic mutations In 2012, CRISPR/Cas was introduced as a precise tool to engineer genomes and epigenomes. This technology has revolutionized biomedical research and approaches ranging from engineered cells and transgenic animals to therapeutic possibilities will be presented. | |||||||||||||||||||||||||||||
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| 15 | Evolutionary Medicine | WBBY039-05 | |||||||||||||||||||||||||||
| We normally think of evolution as optimizing the phenotype of an animal so that it is well-adapted to its environment. So, the existence of diseases such as influenza, cancer or HIV are a puzzle. The course will investigate why and how diseases which are obviously harmful persist over evolutionary timescales? This course will give a broad overview where ecological and evolutionary thinking can advance the understanding of human health and disease. We will cover a range of topics including: - A review of evolutionary genetics and dynamics - The co-evolution of parasites and hosts - Evolution of the immune system - Evolution and origin of human infectious diseases - Evolution of virulence – why are some infectious diseases fatal and others so mild that they are barely noticed? - Evolution of sexually transmitted diseases - The evolution of antibacterial and antimicrobial resistance - Microbiota and human health - Evolutionary processes operating in during cancer development - The evolution of aging and diseases of old age - The evolution of human reproductive disorders and pregnancy complications - Applied evolution The course is suitable for any student interested in evolution and ecology or a biomedical field. | |||||||||||||||||||||||||||||
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| 16 | First Year Symposium | WBBY017-02 | |||||||||||||||||||||||||||
| Students will prepare a poster about a scientific topic, which will be presented at the First Year Symposium (during last week of period Ib). During period Ia, a choice can be made from a large offering of topics with a scientific question. For each topic a staff member will act as a tutor. Groups of 3-4 students each will research the assigned topic with the help of a staff-tutor, and prepare a scientific poster which will address the scientific question. Students will get instructions on how to access and interpret scientific literature, and on how to prepare a scientific poster. At the end of the first semester students will present the poster during the symposium, and will peer-review a poster from another group. | |||||||||||||||||||||||||||||
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| 17 | Food and Metabolism | WBBY041-05 | |||||||||||||||||||||||||||
| A well balanced diet promotes the functioning of the body and prevents diseases. But what is a healthy diet and what is the connection between nutrition and metabolism? How can disturbances in energy metabolism contribute to the development of chronic diseases? These are the central questions in the course Food and Metabolism. During the course, you will learn the role of nutrition and metabolism in the development of chronic diseases such as diabetes and cardiovascular disease. In the lectures, we will address the structure, function and metabolism of macronutrients. In addition, you will gain more insight into the regulation of metabolism. In the work lectures, you will gain a deeper insight into how specific nutrients and/or disturbances in energy metabolism contribute to the pathogenesis of chronic diseases. Under the supervision of an expert, you will perform a literature study in the area of food and metabolic diseases. The results of the literature study will be presented by a presentation and in the form of a scientific literature review. | |||||||||||||||||||||||||||||
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| 18 | Genetics, Ecology and Evolution | WBBY005-05 | |||||||||||||||||||||||||||
| Genetics: Introducing basic principles of genetics and inheritance incl. transmission of genetic information between generations and the genetic basis of traits. Apply basic probability estimates and statistics to inheritance patterns. Topics covered: gene as unit of inheritance, Mendel’s laws, pedigree analysis, multi-allele and -gene inheritance, gene interactions, sex linkage, sex determination, extra-nuclear inheritance, linkage mapping, recombination, chromosome aberrations. Evolution: Introducing evolutionary theory and thinking. History of evolutionary biology. Concepts of natural selection, adaptation, drift, neutral vs. adaptive evolution. Introduction to microevolutionary processes (measuring genetic variation, processes causing changes in allele frequencies natural and sexual selection, fitness concept fitness). Essentials of speciation process (species concepts and rates, reproductive barriers). Basics of phylogenetics (classification, phylogenetic trees, parsimony, molecular clock). Introduction to macroevolution (origin of life, major transitions, extinctions, radiation), information provided by fossil records and biogeography. Basics of genome evolution (genome size and composition, evo-devo, systems biology). Ecology: Introducing basic ecological principles and processes. Gain knowledge on effects of the physical environment and environmental change on organismal distribution patterns and community ecology (interaction between organisms, succession, diversity and food webs) and on how these shape behavioural mechanisms and adaptation. Learn how characteristics of individuals affect population processes. Topics covered: species interactions (competition, predation, disease, parasitism), habitat selection, competition (habitat, niche), population regulation, economic decisions, individual, energetics, ontogeny (flexibility, adaptation), mate choice, parental conflict, competing for resources (ideal free, despotic), mating systems, mechanisms underlying trade-offs and constraints, communication, sexual conflict and sexual selection, living in groups (co-operation), health, ageing and senescence, develop and test hypotheses in ecology. | |||||||||||||||||||||||||||||
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| 19 | Hematopoietic Stem Cells, Differentiation and Development | WBBY055-05 | |||||||||||||||||||||||||||
| Within this course we will study how hematopoietic stem cells (HSCs) are generated during embryogenesis and development, and how we can make HSCs from embryonic stem cells or induced pluripotent stem cells. We will study the molecular mechanisms that underlie the self-renewal properties of HSCs, and which molecular mechanisms drive differentiation of HSCs towards mature erythrocytes, blood platelets and innate or adaptive immune cells. We will focus on signal transduction initiated by cytokines and growth factors but also on epigenetic mechanisms that control the fate of HSCs. Furthermore, we will focus on malignant hematopoiesis and outline the diseases associated with aberrant blood formation. This will include chronic and acute myeloid and lymphoid leukemias, hodgkin and non-hodgkin lymphomas, multiple myeloma and anemia. What are the molecular mechanisms that drive these diseases? What do we know about the role of long non-coding RNAs? What is the role of epigenetics? We will also discuss the clinical aspects of these diseases in detail. What are the latest diagnostic tools? What are the current state-of-the–art treatment options, what are bone marrow stem cell transplantations, and what about immune therapy to treat hematological malignancies? What is the current status of small molecules directed against specific mutations, and have they reached the clinic yet? Besides in-depth lectures students will work in groups of 4 students to write an essay on a specific hematological malignancy. What are the genetic/epigenetic causes of the disease? How is the disease diagnosed and what are current treatment options? Do they work? If not, why not? And where should future research focus on in order to improve treatment outcome? At the end of the course the students will present and discuss their essay with the rest of the students and make a case as to why future EU funding should be made available for that particular hematological malignancy. | |||||||||||||||||||||||||||||
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| 20 | Host-microbe Interactions | WBBY019-05 | |||||||||||||||||||||||||||
| The course addresses advanced concepts in interactions between humans and their gut microbes (microbiota). The course aims to: • Provide emphasis on the host-microbiota interaction with a focus on the link between the gut microbiota, nutrition, health and disease. • Provide multidisciplinary guidance in microbiology, nutrition, microbiota signaling, immunity, and neuroendocrinology. Targets: Education on different aspects of the interaction between the microbiota and nutrition in health and disease. This will discuss a- how the nutrient flow shapes the microbiota and its metabolic profile, which in turn, drive the cross talk between the gut microbes with the host immune, gut-brain axis, metabolic systems, b- how to develop microbiota-based therapy through the manipulation of the microbial community (e.g. fecal transplantation, probiotics and prebiotics). Course content: 1. Introduction to microbiome; oral, skin, and gut (composition and function). (El Aidy) 2. Metagenomic (pathway analysis) and Multi-omics bio-bank cohort analysis (Harmsen) 3. Early live microbiome (Harmsen + El Aidy) 4. Diet and Lifestyle and microbiome (El Aidy) 5. Small intestinal bacteria (link to oral microbiota), Cross feeding among the gut microbes (Harmsen) 6. Host immunity and microbiome (innate and adaptive) (El Aidy) 7. Microbiome and gut disorders (IBD). (Harmsen) 8. Auto-immune diseases (T1-diabetes, Rheumatoid arthritis, Asthma, Multiple sclerosis) (Harmsen) 9. Microbiome and the Gut-Brain axis (El Aidy) 10. Microbiome and neurodegenerative disorders (El Aidy) 11. Microbiome interventions, FMT Pre and Probiotics (Harmsen) | |||||||||||||||||||||||||||||
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| 21 | Human Genetics and Genomics | WBBY042-05 | |||||||||||||||||||||||||||
| This course is a follow-up of the Basic Genetics course. Within the Basic Genetics course students got insight in the organization of the genome in relation to genetic variation and in the importance of identification of disease genes. Techniques used to identify genetic loci involved in monogenic diseases are discussed. Students learned to work with genome browsers and databases. In this follow-up course the research done to identify disease genes for patients suspected of having a monogenic disease, but without a genetic diagnosis, will be taught. Genetic complex diseases are discussed and which genomics techniques are used to identify which genes and which molecular biological mechanisms are involved in the development of diseases. During computer assignments students work with big datasets and by writing a research proposal the question is addressed when to use which genomics methods and how these methods work. Ethical aspects about the use of genomics methods generating big data sets in the clinic and research will be discussed. Contents: - genome wide association studies in large patient cohorts and controls to look for disease genes; - expression profiling of human tissue to get to know which genes or pathways are changed in affected tissue; - use of next generation sequencing in genetic research and diagnostics; - clinical doctors and geneticists present how genomic data is used in a research setting to find new disease genes for clinical daily practice (development of DNA diagnostics). | |||||||||||||||||||||||||||||
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| 22 | Immunology | WBBY020-05 | |||||||||||||||||||||||||||
| Immunology is the academic discipline that studies all aspects of the immune system. This course is the introductory course into Immunology. The course will describe the cells of the Immune System, their development, their organization into tissues, their activation, differentiation and their interactions that form the basis of the immune response. The course will introduce the student into the balance between immunity and tolerance. We will discuss the critical importance of the ability to induce an effective immune response against infectious pathogens such as viruses or bacteria, as well as the harmful consequences of autoimmune responses or unnecessary immunity against harmless environmental agents. The Immunology course aims to provide the student with both knowledge of and insight into the functioning of the immune system in health and disease. | |||||||||||||||||||||||||||||
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| 23 | Immunology and Disease | WBBY043-05 | |||||||||||||||||||||||||||
| The immune system is critical for combating infectious diseases, and its activity can be exploited for the treatment of numerous diseases, including cancer. Dysregulated activity of the immune system lies at the heart of the pathogenesis of numerous diseases, including auto-immune disorders, allergy, asthma, and cancer. Our insight into the immunological basis of these diseases and the possibilities for rational design of innovative therapeutic strategies for their prevention or treatment is progressing at a rapid pace. In this course, students will obtain basic theoretical knowledge regarding fundamental immunological mechanisms to combat infections and their role in immune-mediated diseases. In addition, students will obtain theoretical knowledge regarding immunological techniques and methods to analyse immune responses and how these can be applied for research, diagnostic and therapeutic purposes. This knowledge will be imparted by overview lectures given by expert principal investigators of the UMCG and the RUG. During the practicals, students will become familiar with the execution and application of antibody-based immunological techniques including immunohistochemistry, enzyme-linked immunosorbent assay and flow cytometry. | |||||||||||||||||||||||||||||
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| 24 | Integrative Neuroscience | WBBY006-05 | |||||||||||||||||||||||||||
| The second year course Integrative Neurosciences aims to deepen understanding of neurobiological mechanisms underlying complex behavior and physiology, of which students have acquired basic knowledge during the first year courses “Behavioural Neuroscience” and “Physiology”. In particular, a deepening of the role of sensory information processing through perception of taste and smell, visual information, proprioception, pain/discomfort, are included in this integration, how these sensory information streams are relayed and underlie complex regulatory mechanisms, including regulation of motivated behaviors, body posture and locomotion, and how these process contribute to consciousness and speech. The nervous system will be viewed from different angles including neuroanatomy, neurochemistry, neuroendocrinology, behavioral physiology, and neuropathology. These subjects are part of neurosciences, which is viewed as an integrated entity. Besides the theoretical background, there is a number of practicals including brain anatomy (BA; of the pig brain), dark adaptation in humans (DA), and taste/smell (TS) in humans, and assessing oestrus cyclicity in rodents (OE). | |||||||||||||||||||||||||||||
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| 25 | Lab Course | WBBY021-03 | |||||||||||||||||||||||||||
| Practical: - SMT, including safety measures for working with microorganisms; sterile handling of cells; use of antibiotics Cultivation of cells, including setting up of enrichment cultures; growth in liquid cultures and on solid media, determine growth speed and doubling time in batch culture - Microscopy and analytical methods, use of phase-contrast microscope; cell counting and serial dilutions; identification of bacteria by phenotypic and genotypic methods - Activity assays, including measurements of the catalytic activity of enzymes Experiments will involve SMT & General Microbiological techniques, but will also be linked to the various majors (Molecular Life Sciences, Ecology & Evolution and Medical Biology). Whenever possible, practical data will also be analysed by Biostatistical methods. | |||||||||||||||||||||||||||||
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| 26 | Medical Cell Biology | WBBY045-05 | |||||||||||||||||||||||||||
| Description. Knowledge in cell biology is essential for fundamental and biomedical research. Thus, intracellular processes associated to diseases are explained and subsequently discussed in the context of the development of diagnostic tools and therapies. The proposed topics cover: 1) cell contacts and polarization, 2) neuroplasticity 3) protein folding, 4) degradation mechanisms, and 5) stem cell biology. Each theme is connected to a specific diseases. Insights into the disease pathophysiology are also given during the patient/clinical lectures. The lectures will be organized into 4 blocks. A specific medical theme is central to each block. The clinical problems will be outlined during the patient lectures. The 4 block lectures are concluded with two questions-answers sessions, where unclear points provided by the students are discussed. | |||||||||||||||||||||||||||||
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| 27 | Medical Physiology | WBBY057-05 | |||||||||||||||||||||||||||
| In this course, students will learn about the normal functioning of the human body, by studying the cardiovascular, respiratory, gastro-intestinal, renal physiology, and the role of neurohumoral regulations. Students will also learn about common disturbances in the normal physiology (disease). Students will be challenged to apply the various physiological concepts in interactive lectures and tutorials in medical problems and during exercise. Furthermore, they will study these concepts in various practicals, studying lung function, cardiovascular function, and exercise physiology. | |||||||||||||||||||||||||||||
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| 28 | Medical Structural Biology | WBBY007-05 | |||||||||||||||||||||||||||
| In this course students will get an overview of techniques used for structural characterization and analysis of protein-drug interactions. This will be preceded with an overview of general principles of organization of proteins and nucleic acids. Topics will include structures of proteins (soluble and membrane-embedded) from the drug development point of view; basic principles of drug-protein interactions; biophysical methods to characterize drug-protein complex formation (X-ray crystallography, cryo-Electron Microscopy, Nuclear Magnetic Resonance), and an introduction into fragment based drug design and virtual screening. | |||||||||||||||||||||||||||||
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| 29 | Metabolism | WBBY058-05 | |||||||||||||||||||||||||||
| In this course, the students learn how cells build and preserve themselves, at the biochemical level. Specifically, they will learn the principles how cells absorb, store and recruit energy and nutrients, and convert these nutrients into cell components via metabolic pathways. As careful coordination of these biochemical processes is crucial for cellular function, also the respective regulation mechanisms occurring at various levels will be taught. Finally, in a few lectures, also the key principles of organismal metabolism will be covered. | |||||||||||||||||||||||||||||
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| 30 | Microbes and Infection | WBBY059-05 | |||||||||||||||||||||||||||
| The course consists of a theoretical and a practical part. Theoretical part: The lectures will cover a range of medical aspects of microbiology, such as the structure and classification of bacteria and viruses, replication mechanisms of bacteria and viruses, virulence factors, pathogenesis, relationship with diseases, diagnosis of infectious microorganisms, specific bacterial and viral diseases, zoonosis, prevention (vaccination), antibiotic use and resistance development, antivirals. Practical part: Bacteriology: Use of techniques for identification of pathogenic bacteria, determination of bacteria in a mixture. Detection of the regulation and action of different virulence factors. Determination of antibiotic resistance development of different bacterial strains and analysis of the exchange of genetic material responsible for resistance development. Use of genetic analysis for subtyping of potential pathogenic microorganisms within a species. Virology: Investigation of students’ throat swaps for presence of Epstein Barr virus. Performing a hemagglutination and hemagglutination inhibition assay for determination of virus and antibody titers to influenza virus. Use of quantitative PCR for the determination of a viral load.
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| 31 | Microbiology | WBBY022-05 | |||||||||||||||||||||||||||
| At the end of the course the student has an overview of concepts in microbial physiology and ecology Theory - Structure of the Prokaryotic cell, including differences and similarities of bacteria and archaea in build-up of cell wall, lipid membranes and cytoplasmic architecture; structure of main cell components - Growth of microorganisms, including growth kinetics; auxotrophy and nutrient requirements; growth on surfaces and in solution; environmental factors; microbial communities - Energy transduction, including basic principles of redox reactions,; substrate-level and oxidative phosphorylation; chemiosmotic theory - Metabolic diversity, including carbon, nitrogen and sulfur cycle; aerobic versus anaerobic growth; respiration versus fermentation; chemolithotrophy, phototrophy and heterotrophy - Extremophiles, including ecology of microorganism, metabolic adaptations Industrial microbiology, including overflow metabolism, antibiotic production, - Host-microbe interactions, including pathogenicity, virulence factors, immunity - Taxonomy, including phylogeny and methods to determine evolutionary relatedness | |||||||||||||||||||||||||||||
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| 32 | Minor congress (Life Sciences) | WBBY023-05 | |||||||||||||||||||||||||||
| The student choses a scientific research question related to his/her minor and selects 3 recent scientific publications related to that research question. This selection of research papers is sent for approval to one of the teachers and subsequently the student writes a scientific essay using 1500 words max. Using a peer-review procedure the student provides and receives critical feedback on the written essay and uses this feedback to improve the quality of his/her essay. The student also receives a training on how to professionally present scientific data which will be practiced on a student conference at the end of the course. Furthermore, the student will receive a training in how to write items for high-quality newspapers science sections and write a newspaper science section together with other students. | |||||||||||||||||||||||||||||
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| 33 | Modelling Life | WBBY024-05 | |||||||||||||||||||||||||||
| This course introduces students to the mathematical modelling of biological systems, and covers model development, analysis and interpretation. In order to deal with variation in prior knowledge, students will have an opportunity to identify potential weak spots in their understanding of mathematics, and develop necessary baseline skills in an e-learning environment (SOWISO), where students are able to select personalised practice material based on the results of self-evaluation tests. The new material covered in this course introduces mathematical tools to describe and analyse dynamical interactions and feedback mechanisms in a wide variety of biological systems, including gene-regulation networks, nerve cells, hormonal control mechanism, epidemics of infectious diseases and ecological interactions. Here, we will follow the textbook Modeling Life – The Mathematics of Biological Systems (Garfinkel et al., 2017). Students learn how to develop dynamical models of biological systems and how to determine their dynamical behaviour and equilibrium states, based on an analysis of system trajectories and the underlying vector field. Qualitative (graphical) analysis and simulation are the main tools for generating biological insight; analytical methods are introduced on a need-to-know basis. Topics covered in this course include: ‘Dynamical modelling and simulation’, ‘Equilibrium behaviour’, ‘Non-equilibrium dynamics: oscillations and chaos’, ‘Linear algebra’ and ‘Multi-variable systems’. Students prepare for each topic by reading sections of the book, and are introduced to the new material in a lecture. Next, they develop an active understanding of each topic by working on pen- and-paper and computer exercises, both individually and in a working-group setting. For each topic, one of the working-group assignments has to be handed in for evaluation. The course is concluded with a written exam. | |||||||||||||||||||||||||||||
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| 34 | Molecular Genetics | WBBY008-05 | |||||||||||||||||||||||||||
| This is a follow-up course of the first-year courses Basic Cell and Molecular Biology, and Genetics, Ecology and Evolution. It covers the main concepts of molecular genetic mechanisms in prokaryotic and eukaryotic organisms. Genome organization and integrity, DNA damage and repair, homologous- and site-specific recombination, gene regulation, plasmid biology, genomics and -omics techniques will be further deepened, while also the genetic organization and life cycle of retroviruses, temperate and virulent bacteriophages will be dealt with. Resistance mechanisms against bacteriophages and the subsequent development of genetic engineering and gene editing technology (CRISPR-Cas) will be exemplified. The importance of molecular genetics in developments in Biotechnology, System- and Synthetic Biology and the impact that molecular genetic techniques have in fundamental research, medicine, agriculture and society at large will be discussed. | |||||||||||||||||||||||||||||
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| 35 | Molecular Research in Human Disease | WBBY061-05 | |||||||||||||||||||||||||||
| In this course (5 ECTS) the LS&T students are prepared for a research career in science. Students learn the necessary skills to design and conduct scientific research. They are introduced into various molecular and biochemical techniques and learn about the use of genetically engineered mouse models in unravelling the mechanism of human disease. Students will write an editorial based on a high-impact scientific article and they will devise a research proposal for research into human diseases. Furthermore, students will present their editorial and research proposal to learn to communicate their ideas effectively. Based on the principal of Problem Based Learning, the students also have to solve three cases related to different diseases or aspects there off. In addition, they participate in a 4-day practical session in which they produce results that have to be discussed in their case report. As a result, our course is very different from the other courses in the Bachelor Programme and the students need to present an active attitude, a high level of independence and intrinsic motivation to be able to successfully pass our course. Every single component is graded and thus, the overall score is a good reflection of the student’s ability to be successful in a future scientific career. | |||||||||||||||||||||||||||||
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| 36 | Molecules of Life | WBBY047-05 | |||||||||||||||||||||||||||
| The basic concepts and knowledge on the topic of (organic) chemistry and biochemistry is covered. This lecture is aimed at supporting other molecular-oriented courses and as a preparation for the lectures in bio-organic chemistry and metabolism. The following topics are discussed: 1) Molecular structure and bonding 2) Representation of molecular structures 3) Primary, secondary and tertiary structures of proteins 4) Introduction to reactivity and enzymatic reactions 5) Chemical kinetics and thermodynamics 6) Substitution reactions 7) Reactions of carbonyl groups | |||||||||||||||||||||||||||||
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| 37 | Neurobiology | WBBY077-05 | |||||||||||||||||||||||||||
| This course provides a general introduction to the central nervous system and its relationship to behaviour and disease. The course covers topics ranging from the structure and function of nerve cells to the organization of the brain and higher functions, such as learning and memory, sleep, sexual differentiation, emotion and motivation, to illustrate the brain’s basic functions. Finally, the course will focus briefly on various abnormalities and disorders that can be traced back to changes in the brain. | |||||||||||||||||||||||||||||
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| 38 | Neurobiology of Ageing | WBBY062-05 | |||||||||||||||||||||||||||
| This course will provide a general introduction to the evolution of ageing, and will then focus on the neurobiology of ageing (brain ageing). It will include a more detailed introduction to brain ageing at the genetic, molecular, cellular, systemic, and behavioural level. Concepts of pathological and non-pathological ageing are discussed. Consequences of brain ageing for cognition, neurophysiology, nutrition, and signal transduction pathways are dealt with. In addition, topics such as blood flow and neuroinflammation will be taught in more detail. In addition it will address, among others, the following questions: Why do we age? What is the impact of (traumatic) early life events on brain ageing? How can we slow down brain ageing, and how do we recognize brain ageing? Can it be reversed if we know the underlying mechanisms? At what age does brain ageing start, and is this different for males and females? Is it lifestyle-dependent? Hence, this course will provide a broad overview of issues that play a key role in brain ageing, its functional consequences and the underlying mechanisms. It will address both human and animal research in an integrated fashion. | |||||||||||||||||||||||||||||
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| 39 | Physiology | WBBY011-05 | |||||||||||||||||||||||||||
| In the course students acquire knowledge on anatomy and physiology of the human body. They learn how information from multiple levels of organization, ranging from molecules to cells, tissues, organs and organ systems and at the level of the whole organism is integrated in order to serve an adaptive behavioural and bodily response to various internal and external demands. In the lectures several items will be addressed like 1) homeostasis and control mechanisms, 2) the autonomic nervous system, 3) the central nervous system, 4) respiration, 5) cardiovascular system, 6) kidneys, blood volume and water balance, 7) muscles, 8) digestive system, 9) regulation of energy balance, 10) endocrine control of growth, stress and metabolism, 11) reproduction and development. The theoretical information in these lectures is completed with components of the tutorial programme of MasteringAandP (Interactive Physiology), available from the website of the publisher of the used textbook Human Physiology (7th ed. by Dee Unglaub Silverthorn). Students gain access to this website by buying the recommended (mandatory)textbook. Furthermore, the theoretical information in the lectures and tutorials is combined and applied in practicals on the anatomy of male and female mammals (rattus norvegicus), the anatomy of the heart (sheep) and in a practical on regulation of own heart rate and blood pressure in which students study the cardiovascular response to and recovery from exercise and postural changes (Biopac). | |||||||||||||||||||||||||||||
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| 40 | Regenerative medicine | WBBE015-05 | |||||||||||||||||||||||||||
| Current society, in which people are getting older and older, is increasingly confronted with diseases related to malfunctioning or failing repair mechanisms. Examples include cardiovascular disease, diabetes, renal disease and typical degenerative diseases of the locomotor system (e.g. hips and intervertebral discs). Most of these diseases involve chronic damage and impaired tissue repair. In most cases, they can be traced back to developmental biological principles such as stem cell dysfunction. This introduction to Regenerative Medicine will pay ample attention to, inter alia, the principles of tissue development, cell and stem cell differentiation and dedifferentiation, physiological and pathophysiological repair mechanisms (inflammation, wound healing, fibrosis, rejection of implanted biomaterials) and also the application of this knowledge within a relatively new discipline of medicine: Regenerative Medicine (RM). In all cases, the guiding principle underlying RM is bolstering the body’s inherent regenerative capacity. For this reason, the course unit will pay attention to the explicitly multidisciplinary nature of RM, which is unique among the natural sciences. Within RM, there are collaborations between clinicians (patients’ treatment needs and treatment given), life scientists (problem analysis, science, biological solutions) and biochemists and polymer chemists (development of natural and polymer biomaterials for treatment, release of stem cells and other cells and signal-transduction factors). The course unit mainly focuses on the biological principles underlying regenerative medicine. | |||||||||||||||||||||||||||||
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| 41 | Research Project Biomedical Sciences | WBBY902-10 | |||||||||||||||||||||||||||
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| 42 | Research Skills in Life Sciences 1 | WBBY066-02 | |||||||||||||||||||||||||||
| In the course, students learn academic as well as practical skills in the Life Sciences. The academic skills focus on the critical reading and interpretation of scientific research papers using primary research literature distributed over topics representing three majors in the bachelor programme: Biomedical Sciences, Behaviour & Neurosciences and Molecular Life Sciences. Students can express preference for one of the topics which all share the same learning goals. Assignment will be based, on personal preference as well as capacity. The topics focus on 1) the cardiovascular system/heart failure; 2) neural regulation of social behavior; and 3) molecular aspects of Parkinson Disease. The training of academic skills will take 4 weeks. During several lectures students will receive background information on the topics in the academic skills block. During tutorials, students learn to distinguish structure - elements such as motive, purpose, arguments and conclusions - in the text of research papers using the Scientific Argumentation Model (SAM). After approximately 3 weeks of each reading block, the knowledge of the students on the topic will be tested in an exam (multiple choice). In the final week of the block, students will be tested via individual presentations on their ability to quickly read, summarize and comment on a paper. Other tasks may form part of the assignments. In the practical part of the course, students will become familiar with different molecular biology techniques, and apply principles learned during theoretical courses from the 1st year. The student will solve an authentic problem: i.e. producing vanillin in an environmentally friendly and cheap way. To this end, the students develop an expression vector and produce a recombinant enzyme. In the second week they purify the enzyme and characterize it. The students will also design and perform necessary experiments to produce the highest amount of vanillin by using the enzyme that they prepared. | |||||||||||||||||||||||||||||
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| 43 | Research Skills in Life Sciences 2 | WBBY067-03 | |||||||||||||||||||||||||||
| In the course, students learn academic as well as practical skills in the Life Sciences. The academic skills focus on the critical reading and interpretation of scientific research papers using primary research literature distributed over topics representing three majors in the bachelor programme: Biomedical Sciences, Behaviour & Neurosciences and Molecular Life Sciences. Students can express preference for one of the topics which all share the same learning goals. Assignment will be based, on personal preference as well as capacity. The topics focus on 1) the cardiovascular system/heart failure; 2) neural regulation of social behavior; and 3) molecular aspects of Parkinson Disease. The training of academic skills will take 4 weeks. During several lectures students will receive background information on the topics in the academic skills block. During tutorials, students learn to distinguish structure - elements such as motive, purpose, arguments and conclusions - in the text of research papers using the Scientific Argumentation Model (SAM). After approximately 3 weeks of each reading block, the knowledge of the students on the topic will be tested in an exam (multiple choice). In the final week of the block, students will be tested via individual presentations on their ability to quickly read, summarize and comment on a paper. Other tasks may form part of the assignments. In the practical part of the course, students will become familiar with different molecular biology techniques, and apply principles learned during theoretical courses from the 1st year. The student will solve an authentic problem: i.e. producing vanillin in an environmentally friendly and cheap way. To this end, the students develop an expression vector and produce a recombinant enzyme. In the second week they purify the enzyme and characterize it. The students will also design and perform necessary experiments to produce the highest amount of vanillin by using the enzyme that they prepared. | |||||||||||||||||||||||||||||
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| 44 | Research Skills in Life Sciences 3 | WBBY068-05 | |||||||||||||||||||||||||||
| In the course, students learn academic as well as practical skills in the Life Sciences. The academic skills focus on the critical reading and interpretation of scientific research papers using primary research literature distributed over topics representing three majors in the bachelor programme: Biomedical Sciences, Behaviour & Neurosciences and Molecular Life Sciences. Students can express preference for one of the topics which all share the same learning goals. Assignment will be based, on personal preference as well as capacity. The topics focus on 1) the cardiovascular system/heart failure; 2) neural regulation of social behavior; and 3) molecular aspects of Parkinson Disease. The training of academic skills will take 4 weeks. During several lectures students will receive background information on the topics in the academic skills block. During tutorials, students learn to distinguish structure - elements such as motive, purpose, arguments and conclusions - in the text of research papers using the Scientific Argumentation Model (SAM). After approximately 3 weeks of each reading block, the knowledge of the students on the topic will be tested in an exam (multiple choice). In the final week of the block, students will be tested via individual presentations on their ability to quickly read, summarize and comment on a paper. Other tasks may form part of the assignments. In the practical part of the course, students will become familiar with different molecular biology techniques, and apply principles learned during theoretical courses from the 1st year. The student will solve an authentic problem: i.e. producing vanillin in an environmentally friendly and cheap way. To this end, the students develop an expression vector and produce a recombinant enzyme. In the second week they purify the enzyme and characterize it. The students will also design and perform necessary experiments to produce the highest amount of vanillin by using the enzyme that they prepared. | |||||||||||||||||||||||||||||
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