| 1 | Immunopharmacology | WBFA015-05 |
In the first year the student has learned the basic principles of immunology, this course will improve the immunological knowledge. Subjects presented in this course are:
1. Cells of the innate immune system and adaptive immune system: their origin, how they develop, what they do in homeostatic and pathological conditions and how do they work together during immune responses?
2. B and T cells and antibodies: how is their enormous variation achieved?
3. How does the immune system distinguish self from nonself?
4. The pathophysiology of auto-immune reactions, allergic reactions, acute and chronic inflammation and bacterial/viral/fungal infections.
5. Tolerance and the immune system: how can cancers develop, why can women become pregnant, what does the immune system do with transplanted cells and organs?
6. Immunological techniques: producing and using antibodies and other components of the immune system in the lab for research and diagnosis
7. Pharmacotherapy: drugs that influence cells of the immune system and using the immune system itself for therapies
8. The theory behind vaccination and explanation of vaccination programs |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | prof. dr. B.N. Melgert | | Docent(en) | prof. dr. B.N. Melgert | | Onderwijsvorm | Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC) | | Toetsvorm | Meerkeuze toets (MC), Opdracht (AST), Tussentoets (IT) | | ECTS | 5 |
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| 2 | Medicinal Chemistry and Biophysics | WBFA038-05 |
1. This course unit explains how molecular shape controls biological function. Students are provided with tools with which to describe the relationships between the structure of the pharmaceutical and its biological activity.
2. The process of the binding of pharmaceuticals to DNA, receptors and enzymes will be explained by paying attention to hydrophobic, electronic and steric (shape) parameters.
3. The most commonly used spectroscopic (MS, IR, NMR) and biophysical (ITC, DSF) techniques used to characterize organic molecules will be explained, with a focus on the underlying principles and the interpretation of the data.
4. Finally, the importance of structure–activity relationship (SAR) analysis in drug development will be explained using modern examples. |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | Prof. Dr. M.R. Groves | | Docent(en) | Prof. Dr. A.S.S. DömlingProf. Dr. M.R. Groves | | Onderwijsvorm | Hoorcollege (LC) | | Toetsvorm | Schriftelijk tentamen (WE) | | ECTS | 5 | | Entreevoorwaarden | Option of the FSE minor in molecular sciences. Within the BSc Pharmacy degree, this course follows on almost immediately from the end of the 1st year study and relies upon the students having gained knowledge from the previous years course. The subject materials required for the students to understand prior to starting the MCB course are:
1. basic cell biology (Molecular Biology of the Cell 1/2),
2. molecular reactions (Molecules and Reactivity WBFA055-05),
3. basic mathematics (Mathematics and Statistics WBFA054-05) and
4. receptor pharmacology (Receptor Pharmacology WBFA036-05). | | Opmerkingen | Principles whereby drugs interact with targets is a basic requirement for students to understand
Pharmacokinetics (WBFA018-05) as the shape and medicinal chemistry properties of a drug play an essential role in membrane passage, adsorption and distribution. Understanding drug shape also plays a pivot role in the understanding of the mechanisms of drug Metabolism and Toxicology (WBFA016-05). Finally, a solid grasp of the central tenents of
the course is essential for any student wishing to pursue a career in pharmaceutical research (MSc/PhD/research career). |
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| 3 | Medicines Group: Drugs for the Central Nervous System | WBFA033-05 |
The course provides information on the pharmacology of drugs acting on the central nervous system (CNS). Several brain pathologies are discussed as well. In this course unit, students will get in depth knowledge in underlying mechanisms that play a role in our brain in healthy and in pathological situations.
The following topics will be addressed in this course unit:
- neuroanatomy and related brain functions
- basic function of neurotransmission
- human models to study brain diseases, with an emphasis on imaging techniques
- pharmacology of drugs acting on cholinergic, serotonergic, dopaminergic system (with a focus on brain neurotransmitter pathways)
- molecular pathways and mechanisms of action of drugs used for neurodegenerative diseases (Alzheimer' s disease, Parkinson's disease, stroke), multiple sclerosis, migraines
- mechanisms of action of hallucinogenic substances, antidepressants, antipsychotics, anxiolytics, hypnotics, anticonvulsants and centrally acting analgesics |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | Prof. Dr. A.M. Dolga | | Docent(en) | Prof. Dr. A.M. DolgaProf. Dr. A.S.S. Dömlingprof. dr. P.H. Elsinga | | Onderwijsvorm | Bijeenkomst (S), Hoorcollege (LC) | | Toetsvorm | Meerkeuze toets (MC), Schriftelijk tentamen (WE) | | ECTS | 5 | | Entreevoorwaarden | The course unit assumes prior knowledge from the
Physiology and Pharmacology course unit (WBFA020-05),
Molecular Biology of the Cell 1 (WBFA006-04),
Molecular Biology of the Cell 2 (WBFA007-04),
Receptor pharmacology (WBFA036-05) |
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| 4 | MG: Circulatory Tract | WBFA040-05 |
| The course unit studies the pharmacology and pharmacotherapeutic effect of drugs used to treat the various organ/body systems in relation to the physiology and pathophysiology of the cardiovascular system. |
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| 5 | MG: Endocrine System and Digestive and Respiratory Tract | WBFA039-05 |
In the course MG: Endocrine System and Digestive and Respiratory Tract, the following topics are discussed:
Respiratory tract: bronchodilators, anti-inflammatories, anti-allergics, decongestants, cough medicines;
Digestive tract: stomach / esophagus: anti-ulcer drugs, prokinetics, anti-emetics;
intestines: antispasmodics, anti-diarrheal agents, laxatives, anti-inflammatory agents;
Skin: keratolytics, keratoplastics, anti-inflammatory agents, anti-allergics.
Endocrine system:
- Carbohydrate, protein and fat metabolism: thyroid hormones, antithyroid drugs, glucocorticosteroids, pancreatic hormones, growth hormone.
- Immune system: glucocorticosteroids.
- Water and mineral balance: ADH, mineralocorticosteroids, calcitriol, calcitonin.
- Growth: growth hormone, thyroid hormones, sex hormones.
- Reproduction: estrogens, progestins, anti-estrogens, antiprogestants, contraceptives, oxytocin, prolactin, androgens, anabolic steroids, anti-androgens. |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | prof. dr. R. Gosens | | Docent(en) | dr. H.A. BaarsmaProf. Dr. M. Schmidt | | Onderwijsvorm | Hoorcollege (LC) | | Toetsvorm | Meerkeuze toets (MC), Schriftelijk tentamen (WE) | | ECTS | 5 | | Entreevoorwaarden | The course unit assumes prior knowledge acquired from Physiology and Pharmacology WBFA020-05, Human Physiology WBFA022-03, Pathology WBFA024-05, Receptor Pharmacology WBFA036-05. |
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| 6 | MG: Infectious diseases and Oncology | WBFA041-05 |
| In this course, students learn about the way tumours and infections develop and explore various options for treating them. Infections include bacterial, fungal, viral, protozoan and worm infections. The course unit will deal with the working mechanism and clinical application of various cytostatics, antibiotics, antimycotics, antiviral, antiparasitic, and immunosuppressive drugs, linking these aspects to the chemical structure, pharmacokinetic properties and side effects of the drugs studied. The clinical application of drugs will be illustrated by studying various diseases such as systemic infections (sepsis), AIDS, and certain malignant tumours. Modern production methods for the foremost antibiotics will also be demonstrated. In addition, the course unit will examine the problem of resistance and various other factors determining the decision to use a particular drug, as well as the latest developments in the area of anti-bacterial, anti-viral, immunosuppressive and anti-tumour therapies. |
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| 7 | Organic and Biosynthesis | WBFA008-05 |
The course revolves around the following subjects:
- the chemo-selectivity, regio-selectivity and stereo-selectivity of (synthetic) reactions;
- substitution, addition and elimination reactions;
- reactions of aromatic and carbonyl compounds;
- biosynthesis routes: alkaloids, lignans, terpenoids, steroids, and polyketides;
- pharmaceutical applications of natural products;
- the mechanisms and catalytic properties of two enzymes involved in the biosynthesis of the natural product and anti-cancer drug Taxol: phenylalanine aminomutase and phenylalanine ammonia lyase. |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | prof. dr. G.J. Poelarends | | Docent(en) | M. Crotti, PhD.prof. dr. F.J. Dekkerprof. dr. G.J. Poelarends | | Onderwijsvorm | Hoorcollege (LC), Werkcollege (T) | | Toetsvorm | Schriftelijk tentamen (WE) | | ECTS | 5 | | Entreevoorwaarden | Het vak veronderstelt voorkennis uit Moleculen en Reactiviteit. Het vak wordt vaak gevolgd door/bereidt voor op Organische chemie practicum, BSc Farmacie, waar de hier behaalde leerdoelen als
voorkennis gevraagd worden. | | Opmerkingen | In principle we use the 8th edition of the Study Guide during seminars. The study guide's 8th edition is therefore recommended (but not mandatory), though during seminars students are also allowed to use the 7th edition. |
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| 8 | Pharmacoepidemiology | WBFA028-05 |
In deze cursus komen de volgende onderwerpen aan bod:de plaats van de farmaco-epidemiologie binnen de farmacie;
frequentie- en risicomaten;
onderzoeksobjecten: etiologie, diagnostiek, prognostiek, interventie;
spontanerapportagesystemen, bronnen, databases, record linkage;
onderzoeksopzet: cohort, case-control, dwarsdoorsnede;
typen van bias: informatiebias, selectiebias, confounding;
causaliteit;
precisie en validiteit;
systematische fouten en toevalsfouten;
farmaco-economie;
systematische review en meta-analyse;
het lezen en beoordelen van een farmaco-epidemiologisch artikel.
De cursus wordt als pilot in het Engels gegeven. |
| Faculteit | Science and Engineering | | Voertaal | Engels | | Coordinator | prof. dr. E. Hak | | Docent(en) | dr. S. de Vosprof. dr. E. Hak | | Onderwijsvorm | Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T), Opdracht (ASM) | | Toetsvorm | Meerkeuze toets (MC), Schriftelijk tentamen (WE) | | ECTS | 5 |
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