Ocasys: Ocasys: Online Onderwijscatalogus

Rijksuniversiteit Groningen

Hieronder staan het programma en de vakomschrijvingen van BSc Farmacie Klik op de naam van een vak in een schema om naar de omschrijving te gaan.

Periode	Type	Code	Naam	Taal	ECTS	Uren
» Jaar 1 (hoofdprogramma)
hele jaar	verplicht	WBFA061-03	Professionalism in Pharmacy 1	Engels	3
semester I a	verplicht	WBFA004-03	Genetics	Engels	3
	verplicht	WBFA006-04	Molecular Biology of the Cell 1	Engels	4
	verplicht	WBFA007-04	Molecular Biology of the Cell 2	Engels	4
	verplicht	WBFA010-03	The Cell, a Practical Approach	Engels	3
semester I b	verplicht	WBFA054-05	Mathematics and Statistics	Engels	5
	verplicht	WBFA017-05	Pharmaceutical Technology and Biopharmacy 1	Engels	5
	verplicht	WBFA020-05	Physiology and Pharmacology	Engels	5	variabel
semester II a	verplicht	WBFA022-03	Human Physiology	Engels	3
	verplicht	WBFA055-05	Molecules and Reactivity	Engels	5
	verplicht	WBFA024-05	Pathology	Engels	5
semester II b	verplicht	WBFA034-05	Global Health, Pharmacotherapy and Communication	Engels	5	11
	verplicht	WBFA035-05	Pharmaceutical Analysis A	Engels	5
	verplicht	WBFA036-05	Receptor Pharmacology	Engels	5
» Jaar 2 (hoofdprogramma)
Periode	Type	Code	Naam	Taal	ECTS	Uren
hele jaar	verplicht	WBFA062-04	Professionalism in Pharmacy 2	Engels	4	variabel
semester I	verplicht	WBFA011-05	Biostatistics	Engels	5
semester I a	verplicht	WBFA005-06	Instrumental Analysis	Engels	6
	verplicht	WBFA008-05	Organic and Biosynthesis	Engels	5
semester I b	verplicht	WBFA016-05	Metabolism and Toxicology	Engels	5
	verplicht	WBFA018-05	Pharmacokinetics	Engels	5
semester II a	verplicht	WBFA025-05	Pharmaceutical Microbiology	Engels	5
	verplicht	WBFA028-05	Pharmacoepidemiology	Engels	5
	verplicht	BIVMT	Safe Microbiological Techniques	Engels
semester II b	verplicht	WBFA032-05	Bioanalysis	Engels	5
	verplicht	WBFA015-05	Immunopharmacology	Engels	5
» Jaar 2 (major Medical Pharmaceutical Sciences)
Periode	Type	Code	Naam	Taal	ECTS	Uren
semester II a	keuze	WBFA037-05	Collected Medicine Groups	Engels	5
	keuze	WBFA026-05	Pharmaceutical Technology and Biopharmacy 2	Engels	5
semester II b	keuze	WBFA033-05	Medicines Group: Drugs for the Central Nervous System	Engels	5
	keuze	WBFA056-05	Organic Chemistry Practical	Engels	5
» Jaar 2 (major Pharmacy)
Periode	Type	Code	Naam	Taal	ECTS	Uren
semester II a	verplicht	WBFA026-05	Pharmaceutical Technology and Biopharmacy 2	Engels	5
semester II b	verplicht	WBFA033-05	Medicines Group: Drugs for the Central Nervous System	Engels	5

Opmerkingen	Students in the major Medical Pharmaceutical Sciences that choose the course Collected Medicine Groups are not allowed to follow the course Central Nervous System (WBFA033-05) due to overlap in these courses.
» Jaar 3 (hoofdprogramma)
Periode	Type	Code	Naam	Taal	ECTS	Uren
hele jaar	verplicht	WBFA063-01	Professionalism in Pharmacy 3	Engels	1	variabel
semester II	verplicht	WBFA902-14	Bachelor Research Project	Engels	14
semester II a	keuzegroep A	WBFA050-05	From clinical trials to big data research	Engels	5
	keuzegroep A	WBFA047-05	Introduction to PharmacoEconomics	Engels	5
	keuzegroep A	WBFA046-05	Patient Perspectives in Pharmacy	Engels	5
	keuzegroep B	WBFA043-05	Advanced Bioanalysis	Engels	5
	keuzegroep B	WBFA044-10	Proteins for Biopharmaceuticals & Drug Discovery	Engels	10
semester II b	keuzegroep C/ D	WBFA058-05	Herbal Medicine	Engels	5
	keuzegroep D	WBFA060-05	Intro. to Nanomed. and Drug Targeting	Engels	5
	keuzegroep D	WBFA059-05	Pharmaceutical Techn. and Biopharm. 3	Engels	5
	keuzegroep C	WBFA051-05	Advanced Human Disease Model Technologies	Engels	5
	keuzegroep C	WBFA052-05	Patient cases in laboratory medicine	Engels	5
	keuzegroep C	WBFA048-05	Pharmacology of Chronic Diseases and Ageing	Engels	5	variabel
	keuzegroep D	WBFA049-05	Drug Toxicology and Translational Technology	Engels	5

Opmerkingen	This programme is an example, the Bachelor Research Project will be organised in each period.
» Jaar 3 (major Medical Pharmaceutical Sciences)
Periode	Type	Code	Naam	Taal	ECTS	Uren
semester I b	keuze	WBFA056-05	Organic Chemistry Practical	Engels	5
	keuze	WBFA021-05	Thermodynamica	Engels	5
» Jaar 3 (Minor Pharmacy)
Periode	Type	Code	Naam	Taal	ECTS	Uren
semester I	verplicht	WBFA019-05	Pharmacology Practical	Engels	5
semester I a	verplicht	WBFA038-05	Medicinal Chemistry and Biophysics	Engels	5
	verplicht	WBFA039-05	MG: Endocrine System and Digestive and Respiratory Tract	Engels	5
semester I b	verplicht	WBFA040-05	MG: Circulatory Tract	Engels	5
	verplicht	WBFA041-05	MG: Infectious diseases and Oncology	Engels	5
	verplicht	WBFA056-05	Organic Chemistry Practical	Engels	5

Toon korte vakomschrijvingen

Advanced Bioanalysis

WBFA043-05

Faculteit	Science and Engineering
Voertaal	Engels
Docent(en)
ECTS	5

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Advanced Human Disease Model Technologies

WBFA051-05

In this course, we will build on the basic knowledge of physiology and pathology that students have acquired in the first and second year courses. Current drawbacks of animal models for various pathologies, cellular architecture (2D versus 3D), cell-cell interactions together with the necessity of the 3Rs concerning the animal experiments are further discussed.
Recent technologies and tools to model and to study the pathology of various chronic diseases will be studied. These include, among others, stem cell technologies, CRISPR/CAS for gene editing, microfluidics and organ-on-a-chip.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. A.M. Dolga
Docent(en)	Prof. Dr. A.M. Dolga prof. dr. R. Gosens prof. dr. B.N. Melgert
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Meerkeuze toets (MC), Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	This course assumes prior knowledge acquired in the course Pathology, Immunopharmacology, Receptor Pharmacology, Drugs of the Central Nervous System bachelor first and second year Pharmacy, or equivalent.

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Bachelor Research Project

WBFA902-14

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.J. Woerdenbag
Docent(en)
ECTS	14

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Bioanalysis

WBFA032-05

The following topics will be treated in this course:
Theory:
Introduction to Bioanalysis, Sample Preparation, Separation Methods, Ligand Binding Assays, Mass Spectrometry, Protein Analysis, Biopharmaceuticals, Regulated Bioanalysis, Applied Pharmacokinetics, Therapeutic Drug Monitoring and Toxicology, Clinical Chemistry, Interpretation of Laboratory Data
Practical Part:
Sample Preparation, Protein Analysis, Drug Analysis in Biological Samples
This course is based on prior knowledge from the course Instrumental Analysis. This course prepares students for the following courses: Advanced Bioanalysis (elective course in the 3rd year), Quantitative Bioanalysis, research in this field, as well as for a Masters in Pharmacy or Medical Pharmaceutical Sciences.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. P.L. Horvatovich
Docent(en)	dr. D.A.J. Dijck-Brouwer Prof. Dr. P.L. Horvatovich P.H.M. Le, PhD.prof. dr. D.J. Touw prof. dr. N.C. van de Merbel
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Mondeling tentamen (OR), Practisch werk (PR), Schriftelijk tentamen (WE), Verslag (R)
ECTS	5
Entreevoorwaarden	Students who want to participate need to have followed the course Pharmaceutical Analysis.
Opmerkingen	The capacity of this course unit is 150 participants. Students must be present during the introductory lecture (first lecture of the course). Absence without notification means removal from the course unit. Students must be present during the practical. Students must pass both the written exam and the practicum. The final grade is constituted of the following parts: Written Exam: 50% Practicum: 50% Updated 05-05-2021 LW

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Biostatistics

WBFA011-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. M.J. Bijlsma
Docent(en)	dr. M.J. Bijlsma Prof. Dr. P.L. Horvatovich P.H.M. Le, PhD.
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Het vak veronderstelt voorkennis uit het Voortgezette Wetenschappelijk Onderwijs (VWO).

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Collected Medicine Groups

WBFA037-05

The following topics are covered in the course Collected Medicine Groups:
• Physiology and pathology of major organ systems in cardiovascular system, central nervous system (CNS)
and endocrine system
• Molecular pharmacology of widely used drugs for the treatment of respiratory diseases (e.g. Asthma and
COPD), of diseases affecting the CNS (Parkinson and Alzheimer Disease), of cardiovascular diseases and
Diabetes Mellitus

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.A. Baarsma
Docent(en)	dr. H.A. Baarsma Prof. Dr. M. Schmidt
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Opmerkingen	Students that chose the major Medical Pharmaceutical Sciences may take this course unit, or 1 of the other Medicine Group-course units.

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Drug Toxicology and Translational Technology

WBFA049-05

In this course, we will build on the basic knowledge of toxicology that students have acquired in the second year course on ‘Metabolism and Toxicology’. Interactions of drugs with various systems in the human body will be discussed, with particular focus on toxicological effects drugs may have in these systems. With the arrival of advanced strategies for drug delivery, evaluation of changes in drug toxicity profiles and drug safety are essential. As such, novel and traditional toxicity testing methods and models will be discussed and compared.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. A.P. Nagelkerke
Docent(en)	dr. ir. I.A.M. de Graaf dr. A.P. Nagelkerke prof. dr. P. Olinga
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Bijeenkomst (S)
Toetsvorm	Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	This course assumes prior knowledge acquired in the course Metabolism and Toxicology bachelor second year Pharmacy, or equivalent.
Opmerkingen	30 third-year students from the Bachelor's programme in Pharmacy can participate in this course

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From clinical trials to big data research

WBFA050-05

This course addresses key concepts within clinical drug research ranging from pre-registration clinical trials to regulatory decision-making, post-registration research on drug use and safety, and the use of omics technologies in further personalization of pharmacotherapeutic treatments. Students will acquire knowledge from different perspectives including that of commercial, academic, and governmental parties. The course subjects are dealt with during lectures which are complemented with practical work on managing clinical data (SQL), tutorials on interpreting clinical data, and an assignment in which students will develop ideas for a next phase drug trial and subsequently draft and present a synopsis report for such a trial (CCMO).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. F. Klont
Docent(en)	dr. S. de Vos prof. dr. E. Hak dr. F. Klont prof. dr. E.P. van Puijenbroek
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
ECTS	5

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Genetics

WBFA004-03

The course Genetics is a follow-up and assumes prior knowledge and skills of the courses Molecular Biology of the Cell 1 and 2.
Genetics connects with the learning outcomes xxxxxxx of the Pharmacy bachelor programme.
This course deals with the following subjects:
Mendel genetics;
Inheritance patterns;
Making linkage maps;
Genome and population evolution;
Population genetics;
Pharmacogenetics;
Biotechnology: different techniques to investigate gene expression and the function of genes, the production of new drugs, gene therapy.
The course unit prepares for and provides skills usable in the course units Infections and Tumours, Clinical Chemistry and Pathophysiology, Innovative Therapeutics and Pharmacotherapy.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. M. Borghesan
Docent(en)	dr. M. Borghesan dr. R.H. Cool
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC)
ECTS	3

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Global Health, Pharmacotherapy and Communication

WBFA034-05

The course covers basic concepts of global health, pharmacotherapy, pharmacoepidemiology, pharmacoeconomics and pharmacovigilance. A number of globally relevant chronic and acute diseases are selected as case studies for the course. For each disease, patient cases are presented, some pathophysiological background of the disease, information about the impact/burden of the disease worldwide and relevant treatment guidelines. In particular we focus on the choice of medication, formulation, route of administration, given important patient characteristics including age, gender, comorbidities, contra-indications and drug interactions. This includes comparing effects and side effects of ‘old’ and ‘new’ drugs, based on evidence from clinical trials and observational studies. Other aspects which are covered in case studies are the costs of (new) drugs, global solutions such as the list of essential medicines and the life cycle of medication including the process of approval of new drugs.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. K. Taxis
Docent(en)	prof. dr. T.L. Feenstra dr. C.C.M. Schuiling-Veninga Prof. Dr. K. Taxis R. van Eekeren-Buiten drs. E.C. Weening
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC)
ECTS	5

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Herbal Medicine

WBFA058-05

Herman Woerdenbag
• Broad introduction to medicinal plants: history, source of drugs and drug development, western and non-western herbal medicine, phytotherapy versus homeopathy. • Herbal medicinal products: production process, product characteristics, product quality, importance of standardisation and the availability of scientific preclinical and clinical data.
• EU and Dutch legal and regulatory aspects.
• Safety, adverse effects, herb-drug interactions and pharmacovigilance. • Clinical efficacy, levels of evidence, (lack of) quality of clinical studies with herbal products.
• Herbal medicinal products in therapeutics groups: constituents, pharmacology, safety (central nervous system, circulatory tract, digestive tract, respiratory tract, uropoeietic tract, skin, analgesics, female genital tract, immune system).
• Reliable sources of scientific information and critical assessment of the literature. • Role of the pharmacist as counsellor (for client, patient, GP) and as devil’s advocate.
Kristina Hasslinger
• Medicinal plant research
Eelko Hak
• Overview of types of clinical studies and their quality.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.J. Woerdenbag
Docent(en)	prof. dr. E. Hak Dr. K. Haslinger dr. H.J. Woerdenbag
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Presentatie (P), Verslag (R)
ECTS	5
Opmerkingen	This course is organised primarily for BSc students that cannot follow the elective Patient cases in laboratory medicine and MSc students that cannot follow Stage Apotheekorganisatie, both due to corona related capacity problems. But other students are welcome!

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Human Physiology

WBFA022-03

Theory:
-neurons, neurotransmitters and the brain;
-hormonal processes;
-functioning of muscles;
-respiration and gas transport;
-physiology of the kidneys;
-regulation of food intake, digestion;
-reproduction;
-physiology of sports and exertion
Practical:
-spirometry;
-cardiovascular function;
-histology;
-Biopac

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. C.M. Drion
Docent(en)	dr. B. Buwalda dr. C.M. Drion dr. B.J. Riedstra
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR)
ECTS	3

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Immunopharmacology

WBFA015-05

In the first year the student has learned the basic principles of immunology, this course will improve the immunological knowledge. Subjects presented in this course are:
1. Cells of the innate immune system and adaptive immune system: their origin, how they develop, what they do in homeostatic and pathological conditions and how do they work together during immune responses?
2. B and T cells and antibodies: how is their enormous variation achieved?
3. How does the immune system distinguish self from nonself?
4. The pathophysiology of auto-immune reactions, allergic reactions, acute and chronic inflammation and bacterial/viral/fungal infections.
5. Tolerance and the immune system: how can cancers develop, why can women become pregnant, what does the immune system do with transplanted cells and organs?
6. Immunological techniques: producing and using antibodies and other components of the immune system in the lab for research and diagnosis
7. Pharmacotherapy: drugs that influence cells of the immune system and using the immune system itself for therapies
8. The theory behind vaccination and explanation of vaccination programs

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. B.N. Melgert
Docent(en)	prof. dr. B.N. Melgert
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Tussentoets (IT)
ECTS	5

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Instrumental Analysis

WBFA005-06

In this course the following subjects are addressed:
Theory:
• the principles of a number of instrumental analytical methods used in pharmaceutical analysis, clinical chemistry, toxicology, bioanalytical, medicinal chemistry, pharmacology and
pharmaceutical technology;
• the fundamental physicochemical principles on which the measurement is based and the construction of the instrument, insight into the possibilities and limitations of the method;
• UV-VIS absorbance and fluorescence spectroscopy. Electrochemical principles: redox reactions, the electrochemical cell & electrode potentials; electrochemical analytical methods:
voltammetry, and (bi)amperometric endpoint detection in titrations.
• Separation methods: fundamentals of chromatography, focused on
high-performance liquid chromatography (HPLC).

Lab:
• the emphasis is on learning to use the equipment, understanding the underlying theory;
• Bi-Amperomic titration using electrochemical endpoint
determination.
• Voltammetric titration of drug preparations
• UV-Vis spectrophotometry: determination of pharmaceuticals,
• HPLC: determination of drug preparations and determining chromatographic analysis variables
• critically analysing and assessing measurements and results.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. E.M.J. Verpoorte
Docent(en)	dr. P. de Haan drs. ing. H.W. Dijkhuizen, MSc.ing. E. Post prof. dr. E.M.J. Verpoorte
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Schriftelijk tentamen (WE), Verslag (R)
ECTS	6
Entreevoorwaarden	Successfully completion of Pharmaceutical Analysis A is a mandatory entry requirement for the Instrumental Analysis course. The ARCS course on lab report writing, taught in May/June is a necessary introduction to this skill, necessary for all courses with practical in y2.
Opmerkingen	Students have to achieve a grade of 5.5 in the exam. The average grade of the practical part (average of all three experiments) has to be 5.5 or higher. In case exactly one experimental grade in below 5.5, it must not be below 4.0. In case, exactly two experimental grade are below 5.5, neither of them must be below 5.0. The average grade of the reports must be not lower than 5.0 Only the first lecture is mandatory (introduction to safety in the lab etc.). Student need to attend to pass the course.

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Intro. to Nanomed. and Drug Targeting

WBFA060-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. K. Poelstra
Docent(en)
ECTS	5

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Introduction to PharmacoEconomics

WBFA047-05

An introduction to Pharmacoeconomics at bachelor level, with a focus on trial based economic evaluation (cost-effectiveness analysis) and budget impact analysis.
In comparison to the master course PharmacoEconomics, this course focuses on the use of trial data, and gathering empirical information about cost-effectiveness, as well as analyzing these data. Simulation models are not discussed in this course.
Both courses introduce the concept of cost-effectiveness, the cost-effectiveness plane and interpretation of findings, but the mastercourse goes more into depth.
The course consists of lectures, student presentations and group work (3 assignments)

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. T.L. Feenstra
Docent(en)	dr. P.F.M. Krabbe dr. C.C.M. Schuiling-Veninga dr. A.D.I. van Asselt dr. K.M. Vermeulen
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Opdracht (AST), Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Opmerkingen	Capacity: 42

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Mathematics and Statistics

WBFA054-05

The course deals with basic mathematics that a student of pharmacy requires to successfully complete her/his studies. The course covers logarithms and exponents, their graphs as well as their interpretation, as well as differential calculus including integration. Students learn to perform simple linear regression and statistical testing, and to apply derivatives (to determine extremes of functions), and to solve autonomous and ordinary differential equations. The course frequently uses examples directly related to the practice of pharmacy or pharmacokinetics in order to further motivate the student

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Dr. T.K. Gebretekle
Docent(en)	Dr. T.K. Gebretekle dr. W.P. Krijnen
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course builds on high school pre-knowledge in mathematics and Statistics. This course prepares for first-year practicals and second years statistics course.
Opmerkingen	Adapted IU 15-09-2022

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Medicinal Chemistry and Biophysics

WBFA038-05

1. This course unit explains how molecular shape controls biological function. Students are provided with tools with which to describe the relationships between the structure of the pharmaceutical and its biological activity.
2. The process of the binding of pharmaceuticals to DNA, receptors and enzymes will be explained by paying attention to hydrophobic, electronic and steric (shape) parameters.
3. The most commonly used spectroscopic (MS, IR, NMR) and biophysical (ITC, DSF) techniques used to characterize organic molecules will be explained, with a focus on the underlying principles and the interpretation of the data.
4. Finally, the importance of structure–activity relationship (SAR) analysis in drug development will be explained using modern examples.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. M.R. Groves
Docent(en)	Prof. Dr. A.S.S. Dömling Prof. Dr. M.R. Groves
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Option of the FSE minor in molecular sciences. Within the BSc Pharmacy degree, this course follows on almost immediately from the end of the 1st year study and relies upon the students having gained knowledge from the previous years course. The subject materials required for the students to understand prior to starting the MCB course are: 1. basic cell biology (Molecular Biology of the Cell 1/2), 2. molecular reactions (Molecules and Reactivity WBFA055-05), 3. basic mathematics (Mathematics and Statistics WBFA054-05) and 4. receptor pharmacology (Receptor Pharmacology WBFA036-05).
Opmerkingen	Principles whereby drugs interact with targets is a basic requirement for students to understand Pharmacokinetics (WBFA018-05) as the shape and medicinal chemistry properties of a drug play an essential role in membrane passage, adsorption and distribution. Understanding drug shape also plays a pivot role in the understanding of the mechanisms of drug Metabolism and Toxicology (WBFA016-05). Finally, a solid grasp of the central tenents of the course is essential for any student wishing to pursue a career in pharmaceutical research (MSc/PhD/research career).

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Medicines Group: Drugs for the Central Nervous System

WBFA033-05

The course provides information on the pharmacology of drugs acting on the central nervous system (CNS). Several brain pathologies are discussed as well. In this course unit, students will get in depth knowledge in underlying mechanisms that play a role in our brain in healthy and in pathological situations.
The following topics will be addressed in this course unit:
- neuroanatomy and related brain functions
- basic function of neurotransmission
- human models to study brain diseases, with an emphasis on imaging techniques
- pharmacology of drugs acting on cholinergic, serotonergic, dopaminergic system (with a focus on brain neurotransmitter pathways)
- molecular pathways and mechanisms of action of drugs used for neurodegenerative diseases (Alzheimer' s disease, Parkinson's disease, stroke), multiple sclerosis, migraines
- mechanisms of action of hallucinogenic substances, antidepressants, antipsychotics, anxiolytics, hypnotics, anticonvulsants and centrally acting analgesics

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. A.M. Dolga
Docent(en)	Prof. Dr. A.M. Dolga Prof. Dr. A.S.S. Dömling prof. dr. P.H. Elsinga
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course unit assumes prior knowledge from the Physiology and Pharmacology course unit (WBFA020-05), Molecular Biology of the Cell 1 (WBFA006-04), Molecular Biology of the Cell 2 (WBFA007-04), Receptor pharmacology (WBFA036-05)

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Metabolism and Toxicology

WBFA016-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. ir. I.A.M. de Graaf
Docent(en)	dr. ir. I.A.M. de Graaf drs. ing. H.W. Dijkhuizen, MSc.dr. A.P. Nagelkerke prof. dr. P. Olinga Prof. Dr. A. Salvati
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
ECTS	5
Entreevoorwaarden	Practicum Minimale Cel, Fysiologie & Therapie, Practicum Anatomie & Fysiologie en Humane Fysiologie (of Fysiologie Mens en Dier) zijn ingangseisen voor dit vak. Dit vak is een ingangseis voor Drug Disposition & Toxicology Research.

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MG: Circulatory Tract

WBFA040-05

The course unit studies the pharmacology and pharmacotherapeutic effect of drugs used to treat the various organ/body systems in relation to the physiology and pathophysiology of the cardiovascular system.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.A. Baarsma
Docent(en)	dr. H.A. Baarsma Prof. Dr. M. Schmidt
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5

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MG: Endocrine System and Digestive and Respiratory Tract

WBFA039-05

In the course MG: Endocrine System and Digestive and Respiratory Tract, the following topics are discussed:
Respiratory tract: bronchodilators, anti-inflammatories, anti-allergics, decongestants, cough medicines;
Digestive tract: stomach / esophagus: anti-ulcer drugs, prokinetics, anti-emetics;
intestines: antispasmodics, anti-diarrheal agents, laxatives, anti-inflammatory agents;
Skin: keratolytics, keratoplastics, anti-inflammatory agents, anti-allergics.
Endocrine system:
- Carbohydrate, protein and fat metabolism: thyroid hormones, antithyroid drugs, glucocorticosteroids, pancreatic hormones, growth hormone.
- Immune system: glucocorticosteroids.
- Water and mineral balance: ADH, mineralocorticosteroids, calcitriol, calcitonin.
- Growth: growth hormone, thyroid hormones, sex hormones.
- Reproduction: estrogens, progestins, anti-estrogens, antiprogestants, contraceptives, oxytocin, prolactin, androgens, anabolic steroids, anti-androgens.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. R. Gosens
Docent(en)	dr. H.A. Baarsma Prof. Dr. M. Schmidt
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course unit assumes prior knowledge acquired from Physiology and Pharmacology WBFA020-05, Human Physiology WBFA022-03, Pathology WBFA024-05, Receptor Pharmacology WBFA036-05.

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MG: Infectious diseases and Oncology

WBFA041-05

In this course, students learn about the way tumours and infections develop and explore various options for treating them. Infections include bacterial, fungal, viral, protozoan and worm infections. The course unit will deal with the working mechanism and clinical application of various cytostatics, antibiotics, antimycotics, antiviral, antiparasitic, and immunosuppressive drugs, linking these aspects to the chemical structure, pharmacokinetic properties and side effects of the drugs studied. The clinical application of drugs will be illustrated by studying various diseases such as systemic infections (sepsis), AIDS, and certain malignant tumours. Modern production methods for the foremost antibiotics will also be demonstrated. In addition, the course unit will examine the problem of resistance and various other factors determining the decision to use a particular drug, as well as the latest developments in the area of anti-bacterial, anti-viral, immunosuppressive and anti-tumour therapies.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Dr. K. Haslinger
Docent(en)	Prof. Dr. A.S.S. Dömling prof. dr. H.J. Haisma prof. dr. F.G.A. Jansman prof. dr. M.N. Lub-de Hooge prof. dr. W.J. Quax Prof. Dr. A. Salvati
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC)
ECTS	5
Entreevoorwaarden	There are no entry requirements for this course. However, knowledge of chemistry and biology is recommended.

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Molecular Biology of the Cell 1

WBFA006-04

In the course the following topics will be addressed:
the origin of life; the important building blocks of living cells; the evolution of life;
cytology (pro- and eukaryotic organisms); cell walls and their components; biomembranes; cell organelles; genetics:
DNA, RNA, chromosomes; replication of DNA; division of nucleus; division of cells; virusses; metabolism; physiology of the cell; enzymology; carbohydrate metabolism; citric acid cycle; lipid metabolism, respiratory chain, photosynthesis;
protein structure; protein synthesis, enzyme kinetics; receptors and signal transduction; developmental biology; cell growth and cell differentiation; hormones; gene regulation; molecular biology techniques: electrophoresis, chromatography; polymerase chain reaction; in-vitro cell culturing; biotechnology for pharmacy; biologicals; monoclonal antibodies; interferones; interleukines; genomics en proteomics.
(Ch. 1-9 Alberts et al.)

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G.J. Poelarends
Docent(en)	prof. dr. G.J. Poelarends Dr. S. Schmidt
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC)
ECTS	4
Entreevoorwaarden	Succesfully passed examinations in biology and chemistry from a pre-university education are required. The course is an excellent preparation for the remaining of the BSc pharmacy education and the learning outcomes are essential for entering the remaining of the curriculum. The knowlegde gathered in the course MBOC1 is essential prior knowledge for entering MBOC 2. The course is a mandatory requirement for entering Pharmaceutical Microbiology and Pharmaceutical Technology & Biopharmacy 2.

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Molecular Biology of the Cell 2

WBFA007-04

The MBOC 2 course is the follow up to the MBOC 1 course. The joint topics dealt with and the joint learning outcomes are described in here.
In the course the following topics will be addressed:
the origin of life; the important building blocks of living cells; the evolution of life;
cytology (pro- and eukaryotic organisms); cell walls and their components; biomembranes; cell organelles; genetics:
DNA, RNA, chromosomes; replication of DNA; division of nucleus; division of cells; virusses; metabolism; physiology of the cell; enzymology; carbohydrate metabolism; citric acid cycle; lipid metabolism, respiratory chain, photosynthesis;
protein structure; protein synthesis, enzyme kinetics; receptors and signaltransduction; developmental biology; cell growth and cell differentiation; hormones; gene regulation; molecular biology techniques: electrophoresis, chromatography; polymerase chain reaction; in vitro cell culturing; biotechnology for pharmacy; biologicals; monoclonal antibodies; interferons; interleukines; genomics en proteomics.
(Ch. 10-18 Alberts et al.)

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G.J. Poelarends
Docent(en)	dr. M. Borghesan prof. dr. G.J. Poelarends
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC)
ECTS	4
Entreevoorwaarden	Succesfully passed examinations in biology and chemistry from a pre-university education are required. The course is an excellent preparation for the remaining of the BSc pharmacy education and the learning outcomes are essential for entering the remaining of the curriculum. The knowlegde gathered in the course MBOC1 is essential prior knowledge for entering MBOC 2. The course is a mandatory requirement for entering Pharmaceutical Microbiology and Pharmaceutical Technology and Biopharmacy 2 in Y2.
Opmerkingen	Update LW 120322

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Molecules and Reactivity

WBFA055-05

The following subjects will be dealt with:
1) configuration and bonding
2) molecule structures and their representations
3) an introduction to reactivity
4) reactions of alkenes
5) stereochemistry
6) electron delocalization
7) substitution reactions
8) nucleophilic acyl substitution reactions.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. J. Broos
Docent(en)
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Sufficient knowledge of chemistry at high school level is necessary.
Opmerkingen	Adapted 080622-LW

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Organic and Biosynthesis

WBFA008-05

The course revolves around the following subjects:
- the chemo-selectivity, regio-selectivity and stereo-selectivity of (synthetic) reactions;
- substitution, addition and elimination reactions;
- reactions of aromatic and carbonyl compounds;
- biosynthesis routes: alkaloids, phenylpropanoids, terpenoids, and polyketides;
- pharmaceutical applications of natural products.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Dr. K. Haslinger
Docent(en)	prof. dr. F.J. Dekker Dr. K. Haslinger
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Het vak veronderstelt voorkennis uit Moleculen en Reactiviteit. Het vak wordt vaak gevolgd door/bereidt voor op Organische chemie practicum, BSc Farmacie, waar de hier behaalde leerdoelen als voorkennis gevraagd worden.
Opmerkingen	In principle we use the 8th edition of the Study Guide during seminars. The study guide's 8th edition is therefore recommended (but not mandatory), though during seminars students are also allowed to use the 7th edition.

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Organic Chemistry Practical

WBFA056-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. ir. A.J. Minnaard
Docent(en)
ECTS	5

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Pathology

WBFA024-05

This course deals with pathological and immunological processes in healthy and diseased situations. The course consists of various (interactive) lectures and practical assignments (histology e-learing module and a group project) that are closely related to each other.
In the pathology part, we will first discuss general pathological responses (including cellular stress, adaptation processes, cell death, inflammation and repair, hemodynamics, neoplasia), that is followed by organ-specific pathologies (cardiovascular system, lungs, liver, kidneys, GI-tract, CNS, bones and joints).
In the immunology part, we discuss the history and introduction to key immune cells and structures, the innate and adaptive immunity and some pathologies of the immune system.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. K. Poelstra
Docent(en)	prof. dr. B.N. Melgert prof. dr. P. Olinga
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR), Presentatie (P)
ECTS	5

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Patient cases in laboratory medicine

WBFA052-05

In this course, we build on the basic knowledge of physiology, pathology, medicinal groups and bioanalysis (notably part interpretation of laboratory data) that students have acquired in the first and second year courses. Based on a real-life case, we focus on the presentation of a patient, differential diagnosis, and clinical chemical and immunological analyses and other techniques, needed to confirm or reject the diagnosis. Students will work in small groups to find, describe and interpret guidelines for diagnosis, treatment and follow up of the specific disease presented in the case. After 2 weeks, they prepare for oral presentation of their findings to the whole group of students. The students will be supervised by staff members of the department of Laboratory Medicine, UMCG.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. D.A.J. Dijck-Brouwer
Docent(en)	dr. D.A.J. Dijck-Brouwer dr. K. Meijer dr. A.B. Mulder dr. A.C. Muller Kobold
Onderwijsvorm	Bijeenkomst (S), Opdracht (ASM)
Toetsvorm	Presentatie (P), Opdracht (AST)
ECTS	5
Entreevoorwaarden	Knowledge of physiology, pathology and theoretical background of interpretation of laboratory data (bioanalysis) is needed.
Opmerkingen	20 students can participate. Updated 30-04-2021 LW.

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Patient Perspectives in Pharmacy

WBFA046-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. ir. C.E.M.J. van Dijk
Docent(en)
ECTS	5

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Pharmaceutical Analysis A

WBFA035-05

In deze cursus komen de volgende onderwerpen aan bod:
Theorie:

basisprincipes: chemische evenwichten, activiteiten van ionen in oplossing, de oplosbaarheid van zouten, zuur-basechemie in waterige oplossingen, elektrochemie en redoxreacties;
titrimetrie en het berekenen van belangrijke parameters (zoals concentraties en pH);
UV-spectrometrie als analytische instrumentele techniek.

Praktijk:

titraties: zuur-base en redox;
UV-spectrometrie: kalibratie en zuiverheidsbepaling;
het bijhouden van een labjournaal;
de analyse van geneesmiddelen volgens farmacopeevoorschrift.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. E.M.J. Verpoorte
Docent(en)	dr. P. de Haan ing. E. Post prof. dr. E.M.J. Verpoorte
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Practisch werk (PR), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Dit vak is een ingangseis voor Farmaceutische Analyse B en Farmaceutische Technologie en Biofarmacie II.
Opmerkingen	Het practicumcijfer wordt als volgt berekend: het gemiddelde van de Nestor-toetsen telt voor 40% mee, de voorbereiding, uitvoering en nabespreking van de experimenten voor 40% en de meetbrieven met de resultaten voor 20%. Het eindcijfer wordt voor 75% bepaald door het tentamen en voor 25% door het practicum. Beide onderdelen moeten voldoende zijn. Zowel het practicumdeelcijfer als het tentamendeelcijfer zijn geldig in het huidige collegejaar en in het volgende collegejaar. Dit vak had vorig jaar vakcode WPFA16004

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Pharmaceutical Microbiology

WBFA025-05

In deze cursus komen de volgende onderwerpen aan bod:

a) Theorie:
de prokaryote cel: de bouw en functie van celbestanddelen, verschillen met de eukaryote cel;
groei en voedingseisen van micro-organismen: groeikinetiek, nutriënten en andere milieuparameters;
energietransductie en metabolische diversiteit bij prokaryoten: glycolyse, de citroenzuurcyclus, elektronentransportketens, de
protondrijvende kracht, gisting, anaerobe ademhaling, chemolithotrofie, de vorming van precursors voor biosynthese;
taxonomische diversiteit bij micro-organismen: soort- en stambegrip, domeinen (Bacteria, Archaea, Eukarya);
antibiotica: werkingsmechanisme, toepassingen, resistentie;
sterilisatie en desinfectie: afstervingskinetiek, farmaceutische sterilisatiemethoden met hun toepassingen;
klinische en farmaceutische microbiologie: de normale flora van het menselijk lichaam, interactie met pathogenen, de toxiciteit van
toxinen, isolatie en identificatie van micro-organismen uit klinische monsters, biologische veiligheid, kwaliteitsbeheersing van
farmaceutische preparaten, het gebruik van bacteriën voor analytische doeleinden;
biofilms: het ontstaan van biofilms, pathogenen in biofilms, quorum sensing, antibioticatolerantie.

b) Practicum:
diverse technieken om contaminatievrij en onder VMT-condities te werken;
fasecontrast-microscopie;
sterilisatie d.m.v. UV-straling;
isolatie van micro-organismen, kweken van bacteriecultures in batch, ophopingscultures, het uitstrijken op agarplaten;
het bepalen van de groeisnelheid en verdubbelingstijd in een batch-cultuur;
identificatie van bacteriën m.b.v. genetische technieken;
antibiotica: cross-streak, gehaltebepaling, resistentieoverdracht d.m.v. conjugatie;
onderzoek van de microbiologische zuiverheid van farmaceutische preparaten en grondstoffen volgens de farmacopee.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. R.H. Cool
Docent(en)	dr. R.H. Cool prof. dr. P. Olinga ing. A.B. Zuidhof
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Entry requirements: Molecular Biology of the Cell 1+2 and The Cell, a Practical approach.
Opmerkingen	Het schriftelijk tentamen bestaat uit open vragen en deze vragen gaan over de theorie (inhoud van de hoorcolleges en literatuur). Het practicumcijfer wordt als volgt berekend: de praktische vaardigheid telt voor 20% mee, de uitwerkingen van de resultaten voor 40%, het labjournaal voor 15% en het verslag voor 25%. Alle onderdelen moeten voldoende zijn. Het eindcijfer wordt voor 50% bepaald door het tentamen en voor 50% door het practicum. Beide onderdelen moeten voldoende zijn. Het practicum en de VMT-toets moeten voldoende zijn om het VMT-certificaat te kunnen ontvangen. De VMT-toets telt niet mee voor het eindcijfer, maar moet voldoende zijn om het vak af te kunnen ronden.

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Pharmaceutical Techn. and Biopharm. 3

WBFA059-05

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. W.L.J. Hinrichs
Docent(en)
ECTS	5

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Pharmaceutical Technology and Biopharmacy 1

WBFA017-05

The content of the course consists of the following topics:
Pharmaceutical technological concepts and biopharmaceutics, routes of administration and dosage forms, principles of pharmacokinetics, tablets and tableting, modified-release dosage forms, therapeutic proteins, inhalation, vaccines, parenteral administration, industrial quality assurance, GMP and product care.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.J. Woerdenbag
Docent(en)	prof. dr. H.W. Frijlink dr. W.L.J. Hinrichs prof. dr. P. Olinga dr. H.J. Woerdenbag
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC)
ECTS	5
Entreevoorwaarden	This course unit is an entry requirement for Pharmaceutical Technology & Biopharmaceutics 2.

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Pharmaceutical Technology and Biopharmacy 2

WBFA026-05

Theory:
- The biopharmaceutical aspects of various dosage forms and how the biopharmaceutical aspects can be influenced
- The physico-chemical properties and the pharmaceutical impact of substances used in semi-solid and liquid dosage forms
- The backgrounds of aseptic procedures necessary for the preparation of sterile dosage forms and the principles of monitoring the rooms for these procedures
- The microbiological background of the sterilization process and controls such as sterility, particulate contamination and the osmotic value

Theory during lectures is illustrated during the practical

The practical comprises the following components:
- Dissolution kinetics and programmed release
- Tabletting and tablets
- Compounding
- Sterile dosage forms

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	ing. M.R. Visser
Docent(en)	dr. W.L.J. Hinrichs prof. dr. P. Olinga dr. H.J. Woerdenbag
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Schriftelijk tentamen (WE), Practisch werk (PR)
ECTS	5
Entreevoorwaarden	Entry requirements: MBOC 1 and 2, The Cell, a Practical Approach, Pharmaceutical Technology and Biopharmacy 1.
Opmerkingen	aangepast IU 15-09-2022

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Pharmacoepidemiology

WBFA028-05

In deze cursus komen de volgende onderwerpen aan bod:de plaats van de farmaco-epidemiologie binnen de farmacie;
frequentie- en risicomaten;
onderzoeksobjecten: etiologie, diagnostiek, prognostiek, interventie;
spontanerapportagesystemen, bronnen, databases, record linkage;
onderzoeksopzet: cohort, case-control, dwarsdoorsnede;
typen van bias: informatiebias, selectiebias, confounding;
causaliteit;
precisie en validiteit;
systematische fouten en toevalsfouten;
farmaco-economie;
systematische review en meta-analyse;
het lezen en beoordelen van een farmaco-epidemiologisch artikel.
De cursus wordt als pilot in het Engels gegeven.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. E. Hak
Docent(en)	dr. S. de Vos prof. dr. E. Hak
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T), Opdracht (ASM)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5

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Pharmacokinetics

WBFA018-05

This course covers the following topics
Theoretical:
- the basic mechanisms and physiological background of pharmacokinetic processes: absorption, distribution, elimination, renal and hepatic elimination;
- the plasma concentration-time curve and renal excretion of drugs after intravenous injection, constant-rate infusion, extravascular administration and multiple-dose intravenous administration;
- the calculation of the pharmacokinetic parameters from the plasma concentration-time curve and renal excretion of drugs;
- the calculation of dosage for single and multiple-dose administration of drugs;
- the relation between pharmacokinetic processes and parameters;
- the effect of changes in physiological and pathological processes on the pharmacokinetic parameters, the plasma concentration-time curve and the correct dosage of drugs;
- Pharmacokinetic case studies of the general and hospital pharmacy practice
Practicals:
- Absorption: paracetamol in humans;
- Infusion kinetics: glassman patient:
- Distribution and elimination: drug targeting

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	P.H.C. Åberg, PhD.
Docent(en)	P.H.C. Åberg, PhD. M. Balogh, PhD.ing. E. Post prof. dr. D.J. Touw
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Schriftelijk tentamen (WE), Tussentoets (IT), Verslag (R)
ECTS	5
Entreevoorwaarden	A pass in the following course units: Physiology & Pharmacology.
Opmerkingen	Presence during the following parts of the course is mandatory: Introductory lecture, "Introduction to practicals" lecture and practicals.

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Pharmacology of Chronic Diseases and Ageing

WBFA048-05

The course includes introduction to hallmarks of aging and the contribution of physiology and pharmacology to aging related diseases. It covers basic knowledge of various physiological, immunological and pharmacological concepts and principles. The following are among the topics that will be addressed during the PCDA lectures:
-Chronic diseases of aging, scientific research understanding, critiquing of research, presentation and interpretation of research questions and data, communication, integrative physiology, pharmacological principles, receptors, molecular signalling pathways, the central and peripheral nervous systems, brain functions, the cardiovascular system, respiratory system, and an understanding of the immune system and its contribution to age-related diseases. Importantly pharmacological treatment will be discussed.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.A. Baarsma
Docent(en)	dr. H.A. Baarsma Prof. Dr. A.M. Dolga prof. dr. R. Gosens prof. dr. B.N. Melgert A.M. Sabogal Guaqueta, MSc.Prof. Dr. M. Schmidt M. Trombetta Lima
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Opdracht (AST), Presentatie (P), Verslag (R)
ECTS	5
Opmerkingen	This course has a capacity of 20 bachelor students. Students that also chose the other electives from the basic unit Molecular Pharmacology take precedence.

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Pharmacology Practical

WBFA019-05

An introduction to pharmacological methods and techniques for determining the effect of drugs on the body. Students will initiate their own research protocols to try to identify the effect profile of 3 unknown drugs on the basis of pharmacological reference substances and various pharmacological designs.
Unfamiliar drugs are functionally classified in relation to familiar agonists and antagonists at receptor level by means of contraction experiments on isolated smooth muscle specimens (ileum, trachea, aorta, vas deferens) and heart muscle specimens (atrium), and interactive computer simulations of the effects on blood pressure and heart rhythm, and skeletal muscle function and patient cases.

At the end of the practical, students will correlate and present his/her results and unfamiliar substances will be discussed and clarified.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. H.A. Baarsma
Docent(en)	dr. H.A. Baarsma ing. A.B. Zuidhof
Onderwijsvorm	Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Mondeling tentamen (OR), Verslag (R)
ECTS	5
Entreevoorwaarden	Students must have passed The Cell, a practical approach, Physiology and Pharmacology, Human Physiology and Receptor Pharmacology.
Opmerkingen	Het practicumcijfer wordt als volgt berekend: het gemiddelde van de voor- en nabesprekingen tellen voor 35% mee, het gemiddelde van de groepsverslagen voor 30% en het individuele verslag voor 35%. Het cijfer voor het individuele verslag moet voldoende zijn, 5.5 of hoger. De werkhouding dient ter afronding van het practicumcijfer. Dit vak had vorig jaar vakcode WLFB0705

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Physiology and Pharmacology

WBFA020-05

In the course Physiology and Pharmacology the following topics are discussed:
- Introduction to physiology and pharmacology
- Basic knowledge of a range of physiological, and pharmacological terms and principles (agonist, antagonist etc)
- Communication and homeostasis, integrative physiology, pharmacological principles, receptors and the central and peripheral nervous systems, brain function, the cardiovascular system, endocrinology, respiration, physiology of energy regulation, Diabetes, glucose and insulin.
This course unit dovetails with the learning outcomes A1, A2, A3, A4, A9 and A12 of the Bachelor’s degree programme in Pharmacy.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Prof. Dr. M. Schmidt
Docent(en)	Prof. Dr. A.M. Dolga prof. dr. R. Gosens prof. dr. A.J.W. Scheurink Prof. Dr. M. Schmidt
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR)
ECTS	5
Entreevoorwaarden	This course unit is a prerequisite for Receptor Pharmacology, Pharmacology Practical, Pharmacokinetics, Metabolism & Toxicology, and research and electives at the basic unit Molecular Pharmacology.
Opmerkingen	Assessment (cont.) Digital examination: The content of the lectures (plus guest lectures) will be assessed by means of an examination comprising 76 multiple-choice questions. Students will have 2 hours to complete the examination. The real knowledge percentage is set at 55% real knowledge, and the pass mark is subsequently calculated, corrected for the random chance. Random chance for 4 answer multiple-choice is 25 percent, 19 answers. Mark: If the score < pass mark: mark = 1.0 + 4.5 * (score - random chance) / pass mark - random chance. If the score > pass mark: mark + 5.5 4.5 * (score - random chance) / number of questions - pass mark). Marks over or equal to 5.5 are a pass and all marks below 5.5 are a fail. The average mark will be rounded off to the nearest whole or half mark; a mark of 5.5 will not be given. Students who fail the examination must take a resit. BioPac and Rat practicum: Marks over or equal to 5.5 are a pass and all marks below 5.5 are a fail. The average mark will be rounded off to the nearest whole or half mark; a mark of 5.5 will not be given. Students who fail must take a resit. Updated 09-03-2022 LW

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Professionalism in Pharmacy 1

WBFA061-03

Professionalism in Pharmacy is a series of courses in the first, second and third year of the Pharmacy bachelor, with the following overall goals:

Learning outcome 1: professional attitude
Students should have a professional attitude befitting their academic background and (future) role as professional. This includes the ability to reflect on their own actions and to keep developing personally.

Learning outcome 2: professional communication
Students should be able to communicate their knowledge and ideas clearly and concisely to both fellow professionals as well as non-professional audiences.

Learning outcome 3: professional orientation
Students should familiarise themselves with the field of pharmacy in its full scope, both vocationally and scientifically.

In Professionalism in Pharmacy 1, the focus is on 'getting acquainted' with the learning outcomes and associated skills. The following topics and activities will be covered during the course (the corresponding learning outcome is in brackets):

- First-year mentor programme (1)
- Self-reflection on study choice (1)
- Plagiarism and academic integrity (1)
- Scientific literature (2)
- Writing simple reports (2)
- Poster design (2)
- Pharmacist guest lectures (3)
- Visiting a (community) pharmacy (3)
- Vocational workshops (3)

For poster design, the assignment will be done in cooperation with the course Pathology (WBFA024-05). For writing simple reports, the assignment will be done in cooperation with the course Pharmaceutical Analysis (WBFA035-05).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	B. van Basten, MSc.
Docent(en)	B. van Basten, MSc.
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Opdracht (AST)
ECTS	3
Entreevoorwaarden	No prior knowledge assumed
Opmerkingen	All parts of the course are mandatory unless otherwise specified during the course. Failure to attend will result in additional assignments to complete, related to the missed part(s). Repeated failure to attend will result in failing the course.

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Professionalism in Pharmacy 2

WBFA062-04

Professionalism in Pharmacy is a series of courses in the first, second and third year of the Pharmacy bachelor, with the following overall goals:

Learning outcome 1: professional attitude
Students should have a professional attitude befitting their academic background and (future) role as professional. This includes the ability to reflect on their own actions and to keep developing personally.

Learning outcome 2: professional communication
Students should be able to communicate their knowledge and ideas clearly and concisely to both fellow professionals as well as non-professional audiences.

Learning outcome 3: professional orientation
Students should familiarize themselves with the field of pharmacy in its full scope, both vocationally and scientifically.

In Professionalism in Pharmacy 2, the focus is on ‘practicing skills’ associated with the learning outcomes. The following topics and activities will be covered during the course (the corresponding learning outcome is in brackets):

- Self-reflection on study progress (1)
- Professional and personal development (1)
- Writing complex reports (2)
- Public outreach (2)
- Guest lectures pharmaceutical professionals (3)
- Vocational workshops (3)

For writing complex reports, the assignment will be done in cooperation with the course Instrumental Analysis (WBFA005-06).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	B. van Basten, MSc.
Docent(en)	B. van Basten, MSc.
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Opdracht (AST)
ECTS	4
Entreevoorwaarden	Professionalism in Pharmacy 1 (WBFA061-03) or Academic Research & Communication Skills 1 (WBFA001-05)
Opmerkingen	This course replaces the course Academic Research & Communication Skills 2 (course code WBFA003-04)

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Professionalism in Pharmacy 3

WBFA063-01

Professionalism in Pharmacy is a series of courses in the first, second and third year of the Pharmacy bachelor, with the following overall goals:

Learning outcome 1: professional attitude
Students should have a professional attitude befitting their academic background and (future) role as professional. This includes the ability to reflect on their own actions and to keep developing personally.

Learning outcome 2: professional communication
Students should be able to communicate their knowledge and ideas clearly and concisely to both fellow professionals as well as non-professional audiences.

Learning outcome 3: professional orientation
Students should familiarise themselves with the field of pharmacy in its full scope, both vocationally and scientifically.

In Professionalism in Pharmacy 3, the focus is on ‘integrating skills and insight’ associated with the learning outcomes. The following topics and activities will be covered during the course (the corresponding learning outcome is in brackets):

- Self-reflection on the Bachelor programme and the choice of Master programme (1)
- Ethics and decision making (1)
- The Groningen Research Institute of Pharmacy (3)
- Scientific symposium (3)
- Vocational workshops (3)

Learning outcome 2 (professional communication) will be covered by the Bachelor research project.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	B. van Basten, MSc.
Docent(en)	B. van Basten, MSc.
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Opdracht (AST)
ECTS	1
Entreevoorwaarden	Professionalism in Pharmacy 2 (WBFA062-04) or Academic Research & Communication Skills 2 (WBFA003-04)
Opmerkingen	This course replaces the course Academic Research & Communication Skills 3 (course code WBFA042-01)

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Proteins for Biopharmaceuticals & Drug Discovery

WBFA044-10

The course is an elective in the cluster in the 3rd year of the BSc Pharmacy Programme. It focuses on biopharmaceuticals as well as drug design. The course consists of several parts:
1. Lectures on the topics of biotechnology and biopharmaceuticals, protein engineering, small molecule drug design, analytical techniques for (bio)pharmaceuticals as well as metabolism of therapeutic proteins.
2. A computer practical on molecular docking
3. A practical course on plate reader protein assays
4. A case study at a biotechnology company.
An obligatory part of the course is an excursion week in which 2-3 Dutch biotechnology companies in the Pharma sector will be visited.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Dr. S. Schmidt
Docent(en)	prof. dr. F.J. Dekker Prof. Dr. M.R. Groves prof. dr. W.J. Quax Dr. S. Schmidt
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Schriftelijk tentamen (WE), Verslag (R)
ECTS	10
Opmerkingen	Maximum capacity is 25 students. This course is organised primarily for Pharmacy students. If you are not a Pharmacy student, but you think that this course fits nicely in your programme, please contact the course coordinator.

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Receptor Pharmacology

WBFA036-05

Earlier on in year 1, the student has become acquainted with the most important principles in physiology, including defense
mechanisms and immunology, and is able to understand and explain these principles in the therapeutic approach to pathologies using
pharmacological interventions. In the receptor pharmacology course, more attention will be given to the underlying mechanisms that
play a role in physiology and pathophysiology. It concerns a deepening of the therapeutic approach to diseases by pharmaceutical
companies. The following topics are covered in this course:
1. General pharmacology including central definitions in pharmacology: agonism, antagonism, inverse agonism, receptor reserve,
receptor regulation (desensitization); signal transduction mechanisms: G protein-coupled receptors, ligand-gated ion channels,
kinase-linked receptors, nuclear receptors, crosstalk between signal transduction mechanisms;
2. Immunopharmacology including histamine and autacoids and their receptors, non-steroidal anti-inflammatory drugs (NSAIDS) and
corticosteroids.
3. The basic principles of neurotransmission: pre- and post-synaptic receptors, co-transmission; local anesthetics.
4. The cholinergic and adrenergic system and their role in (para)sympathetic regulation and skeletal muscle physiology.
5. An introduction into neuropharmacology, including dopaminergic and serotonergic receptor systems.
This course is in line with the learning outcomes xxxxx of the Bachelor's degree in Pharmacy (TER Appendix I).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. R. Gosens
Docent(en)	Prof. Dr. A.M. Dolga prof. dr. R. Gosens Prof. Dr. M. Schmidt
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course unit assumes prior knowledge from the Physiology and Pharmacology course unit (WBFA020-05). This course unit is an entry requirement for the Pharmacology Practical (WBFA019-05).
Opmerkingen	Random chance + realistic knowledge rate / 100 * ((multiple-choice questions - random chance) + essay question 1 + essay question 2) Mark: If the score < pass mark: mark = 1.0 + 4.5 * (score - random chance) / pass mark - random chance If the score > pass mark: mark + 5.5 4.5 * (score - random chance) / number of questions - pass mark) Determination of the final mark for the course unit: the knowledge percentage is set at 55% and the pass mark is subsequently calculated, corrected for random chance. Marks over or equal to 5.5 are a pass and all marks below 5.5 are a fail. The average mark will be rounded off to the nearest whole or half mark; a mark of 5.5 will not be given. Students who fail the examination must take a resit. Dit vak had vorig jaar vakcode WPFA18007

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Safe Microbiological Techniques

BIVMT

Zie voor meer informatie de cursus Pharmaceutical Microbiology.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. J.A.K.W. Kiel
Docent(en)
ECTS

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The Cell, a Practical Approach

WBFA010-03

Two, or by exception three, students will form a team to perform experiments in the areas of cell biology, molecular biology, biochemistry and genetics. Some techniques are: bacterial production of a biopharmaceutical; protein purification; testing of biopharmaceutical on cancer cells; measuring the enzymatic activity of a beta-lactamase; SDS-polyacrylamide gel electrophoresis; restriction analysis of DNA/plasmids; transfection of eukaryotic cells; isolation of buccal epithelial cells; PCR; microscopy.
To perform these experiments, the students will use an inquiry based lab education software (https://www.labbuddy.net/) under guidance of assistants. During the practical, each student will keep track of his/her work in a lab notebook. This notebook can and will be controlled by an assistant. After the first practical week, each student will hand in a concept of a report on the performed experiments. The assistants will give comments and advice, but not grade this version. The final report, incorporating these comments, will be graded on: completeness; clarity; critical and logical analysis of data; formulation and conclusions.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G.J. Poelarends
Docent(en)	dr. R.H. Cool
Onderwijsvorm	Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Verslag (R)
ECTS	3
Opmerkingen	Course capacity: max. 200 Adapted 251121 LW

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Thermodynamica

WBFA021-05

- Gassen: ideale gaswet, beschrijving reële gassen, toestandsgrootheden, toestandsfuncties.
- Eerste hoofdwet: arbeid, warmte, interne energie, enthalpie, isotherme en adiabatische veranderingen van interne energie en enthalpie, thermochemie.
- Tweede hoofdwet: entropie, spontane processen, Gibbs energie en chemische potentiaal.
- Fasenleer: fasenovergangen.
- Mengsels: chemische potentiaal vloeistoffen en colligatieve eigenschappen.
- Chemisch evenwicht: reactie-evenwicht, partitiecoëfficient, oplosbaarheid.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. W.L.J. Hinrichs
Docent(en)	dr. W.L.J. Hinrichs
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5

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