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Faculteit Science and Engineering
Jaar 2018/19
Vakcode WMMP13001
Vaknaam Pharmacoepidemiology
Niveau(s) master
Voertaal Engels
Periode semester I b

Uitgebreide vaknaam Pharmacoepidemiology
Leerdoelen 1) The student is able to reproduce and describe: the basic concepts of epidemiology (e.g. measures of frequency and associations, research focus as etiology, diagnostics, prognostics and intervention, main study designs, causality theory, validity and generalizability, basic data-analysis techniques, systematic and random errors, effect modification, and basic pharmaco-economic concepts).
2) The student can examine the main research question, study design, study population, sources of information, exposure and outcome, misclassification and types of biases (information bias, selection bias and confounding) in a pharmacoepidemiological study paper.
3) The student is able to calculate frequency measures, life-tables, association measures, standardized effect measures (direct and indirect) and Mantel-Haenszel stratification measures.
4) The student can debate the pros and cons of different study designs (e.g. RCT, case-control, cohort, prevalence study) and quality of measure instruments.
5) The student is able to calculate confidence intervals for different frequency measures and association measures and to understand their value in relation to p-values.
6) The student is able to understand and judge elementary statistics such as statistical distributions and statistical testing and knows the basics of multivariate regression analysis such as linear, logistic and Cox-regression analysis and can apply multivariate logistic regression.
7) The student has basic knowledge about data collection methods and can examine study data using a statistical program and can interprete the statistical output.
8) The student is able to critically review a pharmaco-epidemiological study (article) and to evaluate its quality
Omschrijving Introduction in the pharmacoepidemiology which forms the basis for the conceptual basic understanding and judgement of pharmacoepidemiological research as presented in the scientific literature. The following questions will be central: 1. What is the research question? Why is this question of interest to pharmacists? What is already known in the literature? 2. What study design has been chosen and why? What is the definition of the study population? Which in- and exclusion criteria are used? Why? 3. What are according to the student and the authors the potential strengths and shortcomings of the study? How can the conclusion be interpreted? 4. What do the results of the study mean for clinical practice? The following topics will be touched upon during the lectures and practicals: position of pharmacoepidemiology within pharmacy, frequency measures, spontaneous reporting systems, sources of information, record linkage, databases, study designs and risk measures, bias and confounding, causality, literature review, pharmaco-economics and how do I appraise a pharmacoepidemiological study article.
Uren per week
Onderwijsvorm Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm Schriftelijk tentamen (WE), Tussentoets (IT)
Vaksoort master
Coördinator prof. dr. E. Hak
Docent(en) and others ,prof. dr. E. Hak ,prof. dr. M.J. Postma ,dr. C.C.M. Schuiling-Veninga
Verplichte literatuur
Titel Auteur ISBN Prijs
Epidemiology: an introduction. K. Rothman. 2008
Entreevoorwaarden The course unit assumes prior knowledge acquired from (BSC Life Sciences, year 3), and Medical Statistics/Biostatistics elementary course at BSc level.
Opmerkingen Students who accomplished the equivalent course far-epi (= farmacoepidemiologie) in their bachelor programme cannot take this course in the master programme and need to follow 5 ECTS other relevant MSc course.

Minimum number of students 3
Opgenomen in
Opleiding Jaar Periode Type
MSc Medical Pharmaceutical Sciences: Spec. Medical Pharmaceutical Sc. research  (Electives) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Spec. Pharmaceutical Design and Engineering  (Other possible Electives) - semester I b keuze
MSc Medical Pharmaceutical Sciences: Spec. Science, Business and Policy  (Electives (10 ECTS)) - semester I b keuze
MSc Medical Pharmaceutical Sciences: track Pharmaco-epidemiology  ( Master Courses) - semester I b verplicht
MSc Medical Pharmaceutical Sciences: track Toxicology and Drug Disposition  (Electives ) - semester I b keuze