Advanced pharmacokinetics

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WMMP005-05
Vaknaam Advanced pharmacokinetics
Niveau(s) master
Voertaal Engels
Periode semester I a

Uitgebreide vaknaam Advanced pharmacokinetics
Leerdoelen At the end of the course, the student is able to:
1) explain the meaning, relevance and application of pharmacokinetic terms and processes.
2) analyze, interpret and evaluate pharmacokinetic information and to apply this into practical advice on dose
3) predict and evaluate the consequences of various physiological and pathological changes on the pharmacokinetics and
therapeutic effects and to give advice on dose adjustment.
Omschrijving The principles of pharmacokinetics, sources and consequences of inter-individual variability in pharmacokinetics, pharmacokinetic
drug interactions, multi-compartment kinetics, nonlinear kinetics, metabolite kinetics, pharmacokinetics of biopharmaceuticals,
relationship between pharmacokinetics and pharmacodynamics, modeling and simulation, data analysis, and the principles of dose
individualization of pharmaceutical products on the basis of age, weight, renal function, population pharmacokinetics and
concentration measurements (therapeutic drug monitoring).
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM)
(Lectures: 41 hours, Homework assignment: 20 hours, Self study: 78 hours)
Toetsvorm Opdracht (AST), Schriftelijk tentamen (WE)
(See REMARKS for more information about the assessment)
Vaksoort master
Coördinator P.H.C. Åberg, PhD.
Docent(en) P.H.C. Åberg, PhD. , P.J. Colin , Guest Lecturer(s) ,dr. J. Stevens ,prof. dr. D.J. Touw
Verplichte literatuur
Titel Auteur ISBN Prijs
Additional study material (powerpoint presentations, handouts, study problems and answers) will be given on Nestor
Clinical pharmacokinetics and Pharmacodynamics: concepts and applications, 5th edition
Malcolm Rowland, Thomas N. Tozer, Hartmut Derendorf, Stephan Schmidt 978-0-7817-5009-7 ca. €  90,00
Entreevoorwaarden BSc course WBFA16003 Pharmacokinetics. Specifically, the student should be able to:
- describe the mechanisms of basic physiological and pharmacokinetic processes;
- explain the connection between pharmacokinetic processes and parameters;
- describe the drug plasma concentration as a function of time curve after various administration methods;
- calculate pharmacokinetic parameters from the drug plasma concentration time curve and renal excretion data;
- design dosage regimens on the basis of multiple administration of drugs.
Opmerkingen The grade for the full course is a weighted average of the written exam (weight 80%) and the hand-in assignments (weight
20%). For the written exam, the final grade on the exam is calculated as 1 + 9*score/maximum score. The total grade for all the
hand-in assignments combined is calculated in the same way, that is, as 1 + 9*score/maximum score.

Mandatory presence: Yes , Presence at the first contact meeting is mandatory.
Opgenomen in
Opleiding Jaar Periode Type
MSc Courses for Exchange Students: Pharmacy - semester I a
MSc Farmacie  (Keuzevakken) - semester I a keuze
MSc Medical Pharmaceutical Sciences: Drug Toxicology & Translational Technology  ( General Outline) - semester I a verplicht
MSc Medical Pharmaceutical Sciences: Pharmaceutical Design and Engineering  (Other possible Electives) - semester I a keuze
MSc Medical Pharmaceutical Sciences: Pharmacoepidemiology & Pharmacoeconomics  (Electives) - semester I a keuze
MSc Medical Pharmaceutical Sciences: Research  (Electives) - semester I a keuze
MSc Medical Pharmaceutical Sciences: Science, Business and Policy  (Electives (5 ECTS)) - semester I a keuze