Organic Synthesis, Methods and Strategy 2

Faculteit Science and Engineering
Jaar 2020/21
Vakcode WMCH024-05
Vaknaam Organic Synthesis, Methods and Strategy 2
Niveau(s) master
Voertaal Engels
Periode semester II b

Uitgebreide vaknaam Organic Synthesis, Methods and Strategy 2
Leerdoelen At the end of the course, the student is able to:
1. analyse a given synthesis route in terms of molecular complexity, sensitivity (reactivity), convergence and key transformations.
2. critically compare given synthesis routes to a target molecule in terms of step count, yield, and practicality.
3. propose a protecting group strategy for a given synthesis route.
4. apply the key synthetic transformations treated in this course in a design of a synthesis route to a given target molecule.
5. design a synthesis route of 4 to 6 steps, including reagents and reaction conditions, given either the target molecule or both the starting material and the target molecule.
6. understand and apply the concepts of the Disconnection Approach to formulate a retrosynthetic analysis
Omschrijving As a synthetic organic chemist, you are challenged daily to develop a synthesis route, perform the reactions and interpret the results, in order to make the desired molecules. Being able to come up with a feasible synthesis route is crucial to this endeavor, and central to this course.

The students will start with the concepts of the famous 'Disconnection Approach', in which they learn to make logical disconnections in a retrosynthetic analysis. This is followed by three topics, for which the students will learn theoretical and design/strategy aspects: radical reactions and photo-redox catalysis, mechanical bonds, and carbohydrate chemistry.

The course is designed in such a way that students receive theoretical training on each topic in two lectures, which will be followed by a tutorial given by the lecturer in the same week. It is highly recommended to attend the tutorials, as they will be interactive. This will provide an ideal opportunity for the students to test their ability in designing a synthesis route (on the blackboard), which is an important skill as a chemist, but also is a good preparation of the exam of this course and necessary in the Final Exam of MSc Chemistry.
Uren per week
Onderwijsvorm Hoorcollege (LC), Werkcollege (T)
(Total hours of lectures: 16 hours, self study: 116 hours, tutorial: 8 hours.)
Toetsvorm Schriftelijk tentamen (WE)
(Open questions. 50% of the work is reproduction, 50% is insight, bringing facts to a higher level of abstraction. The students need to earn a grade of 5.5 on the exam.)
Vaksoort master
Coördinator M.T.C. Walvoort, PhD.
Docent(en) prof. dr. B.L. Feringa ,prof. dr. ir. A.J. Minnaard , N.R.M. Reintjens, MSc. ,dr. W.C. Szymanski , M.T.C. Walvoort, PhD.
Verplichte literatuur
Titel Auteur ISBN Prijs
Chapters of "Classics in Total Synthesis"; will be provided by the coordinator.
Not mandatory:
Organic synthesis: the Disconnection Approach
Stuart Warren
Entreevoorwaarden The course unit assumes prior knowledge acquired from Organic Synthesis: methods and Strategy I , part of the MSc Chemistry, and a BSc in Chemistry.
Opmerkingen This course was registered last year with course code CHOMS205E
Opgenomen in
Opleiding Jaar Periode Type
MSc Chemistry: Advanced Materials  (Electives) - semester II b keuze
MSc Chemistry: Catalysis and Green Chemistry  (Electives) - semester II b keuze
MSc Chemistry: Chemical Biology  (Electives) - semester II b keuze
MSc Chemistry: Erasmus Mundus Theoretical Chemistry and Computing Modelling  (Electives) - semester II b keuze
MSc Chemistry: Science, Business and Policy  (Electives) - semester II b keuze
MSc Courses for Exchange Students: Chemistry - Chemical Engineering - semester II b
MSc Nanoscience  (Optional Courses) - semester II b keuze