Molecular Biology of Ageing and Age-related Diseases

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WMBM017-05
Vaknaam Molecular Biology of Ageing and Age-related Diseases
Niveau(s) master
Voertaal Engels
Periode semester I b
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Molecular Biology of Ageing and Age-related Diseases
Leerdoelen At the end of the course, the student is able to:
1) describe how global methylation, histone modifications, chromatin remodeling, transcriptional noise, RNA processing
aberrations, impaired DNA repair, and chromosomal instability are implicated in ageing
2) define how the proteasome, lysosome, autophagy, and chaperones systems impact protein (re)folding and aggregation
in ageing.
3) explain the role of stem cells in ageing. The students should be able to summarize the changes stem cell undergo with
age and the consequences of the stem cell exhaustion for the human organism
4) summarize how mitochondrial dysfunction, the growth hormone signaling pathways, the IGF-1 signaling pathway and
dietary restriction are implicated in ageing
5) describe the mechanism of cellular senescence and discuss the biological pathways implicated in senescence.
6) review approaches and model system used for studying ageing and illustrate these with examples
7) describe the syndromes of premature ageing in particular HGPS
8) discuss the ageing process in the light of evolution and illustrate it with examples & debate the promises and
limitations of ageing research for the development of interventions that enable people to lead longer and healthier
lives
9) describe the materials of scientific lecture in their own words and to distinguish between key and secondary aspects.
Additionally the students should be able to formulate questions about the lectures.
10) compose an assay on a research question that connects multiple hallmarks of ageing. argue and defend their own
opinion on the topic. The students should be able to evaluate scientific assays.
Omschrijving Ageing can be defined as the gradual loss of the ability of the organism to maintain homeostasis. In this course we focus on the
molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails, resulting in ageing and age
related disease. We will evaluate to what extent the up-to date knowledge on the molecular biology provides opportunities for
interventions, also when considering what we learn from evolutionary theories of ageing. We present the model systems and
experimental strategies that are used in ageing research.
This course will be supported by a team of specialists in different fields of ageing that will provide lectures and reading material. The
course will be further supported by materials from an online course "Why do we age? The molecular mechanisms of ageing".
The course not only gives an overview of the research field of ageing but also teaches scientific writing, active listening and giving feedback to peers.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
(lectures, literature study, assay writing, presentations.)
Toetsvorm Meerkeuze toets (MC), Opdracht (AST), Verslag (R)
(The course grade is composed of 2/3 the exam grade and 1/3 the essay grade plus, if applicable, bonus points. The exam grade is calculated as follows: personal grade exam + 1/3 x (group grade-year average exam). The exam grade must be >5.5 to pass the course.)
Vaksoort master
Coördinator prof. dr. L.M. Veenhoff
Docent(en) and others , S. Bergink, PhD. ,prof. dr. C.F. Calkhoven ,prof. dr. G. de Haan ,dr. M. Demaria ,prof. dr. ir. F. Foijer ,prof. dr. V. Guryev ,dr. M.H.K. Linskens ,dr. L.J. Mouton ,prof. dr. ir. E.A.A. Nollen ,prof. dr. J.J. Schuringa ,prof. dr. S. Verhulst
Verplichte literatuur
Titel Auteur ISBN Prijs
Scientific literature (reviews)
Powerpoint presentations of the lectures
Online video lectures
Entreevoorwaarden The course unit assumes prior knowledge acquired from the bachelor program 'life sciences'.
Opmerkingen Max. capacity: 35 students. This is a MSc. Biomedical Sciences course unit: see student portal for priority regulations in place.
Opgenomen in
Opleiding Jaar Periode Type
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