Molecular and Cellular Neuroscience

Faculteit Science and Engineering
Jaar 2022/23
Vakcode WMBC016-05
Vaknaam Molecular and Cellular Neuroscience
Niveau(s) master
Voertaal Engels
Periode semester I b

Uitgebreide vaknaam Molecular and Cellular Neuroscience
Leerdoelen At the end of the course, the student is able to:
1. To apply theoretical knowledge about neuroscience approaches and use these to analyse phenomena in the neuroscience field.
2. Formulate own research objectives and research questions within genomics/proteomics, signalling and model systems in neuroscience
3. Evaluate several approaches to theoretically answer research questions and choose the most applicable approach based on solid argumentation
4. Present and defend a chosen approach to peers in their scientific field
Omschrijving Block 1 (2 weeks): Genomics, Gene regulation and signal transduction
The first part of the course consists of a lecture series addressing the molecular biology of neuronal gene regulation during development, differentiation and disease. Additionally, some guest lectures will be given.
- Introductory lesson/Distribution of papers for the final presentation, U.L.M. Eisel
- The basis of neuronal gene regulation and function, U.L.M. Eisel
- The neuron restricted silencer as an example of neuronal gene regulation, B. Eggen
- Molecular Neuroendocrinology, G. Van Dijk
- Functional Genomics, J.-C. Billeter

Block 2 (2 weeks): Proteomics and model systems
In the second part of the course students will receive lectures addressing different approaches in studying various physiological and pathophysiological processes using genomics or model organisms. Additionally, some guest lectures will be given.
- Circadian rhythms, Roelof Hut
- Mechanisms of Signal transduction, I M. Schmidt
- C. elegans as model system in neurodegenerative diseases, E. Nollen
- Drosophila as a model organism in Neurobiology, O. Sibon
- Transgenic and Knock out Mouse Models, U.L.M. Eisel
- From Genotype to phenotype: Behavioural testing, E.A. van der Zee
- Proteomics approaches in Molecular Biology, R. Bischoff.

Practicum: Analyzing transgenic animals

Student symposium presenting and discussing scientific publications in form of a talk in small groups.

Writing a reviewing article and submission to a Journal (Journal Club Section of Journal of Neuroscience)
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm Presentatie (P), Schriftelijk tentamen (WE)
(Final grade: 35% x WE(1) + 35% x WE(2) + 30% x P)
Vaksoort gevorderd
Coördinator Prof. Dr. U.L.M. Eisel
Docent(en) Prof. Dr. J.C. Billeter ,prof. dr. P.P. De Deyn ,prof. dr. B.J.L. Eggen ,prof. dr. R.A. Hut ,prof. dr. ir. E.A.A. Nollen ,Prof. Dr. M. Schmidt ,prof. dr. O.C.M. Sibon ,prof. dr. E.A. van der Zee ,prof. dr. G. van Dijk
Verplichte literatuur
Titel Auteur ISBN Prijs
Material for studies and self-studies (as preparation for the student seminar) are original research papers provided by the various lecturers.
Entreevoorwaarden This course is available for BCN research master students only.
Opgenomen in
Opleiding Jaar Periode Type
MSc Behavioural and Cognitive Neurosciences: Behavioural Neurosciences  (Electives: courses from other tracks) 2 semester I b keuze
MSc Behavioural and Cognitive Neurosciences: Cognitive Neuroscience & Modelling  (Compulsory course units) 1 semester I b keuze
MSc Behavioural and Cognitive Neurosciences: Cognitive Neuroscience & Modelling  (Electives: courses from other tracks) 2 semester I b keuze
MSc Behavioural and Cognitive Neurosciences: Molecular & Clinical Neurosciences  (Compulsory course units) 1 semester I b verplicht