Genetics and Evolution

Uitgebreide vaknaam	Genetics and Evolution
Leerdoelen	At the end of the course, the student is able to: Genetics 1. Describe the structure of chromosomes 2. Describe the meiosis and explain how abnormalities occur in chromosome numbers; 3. Recognize different inheritance patterns by reference to pedigrees or phenotype frequencies; 4. Determine the genomic distance between genes ("linkage-map") using recombination frequences 5. Explain mechanisms of genome evolution 6. Use the Hardy-Weinberg equation to calculate genotype frequencies within a population and explain what factors the genotype frequencies in a population may deviate from the Hardy-Weinberg ratio; 7. Describe various techniques to investigate the expression and function of genes; 8. Explain how biotechnology contributes to the development and production of new medicines, including gene therapy; Evolution 1. Describe the forces that drive the evolution of prokaryotic and eukaryotic organisms. 2. State the nature and dynamics of genetic variation within prokaryotic and eukaryotic populations and species in relation to their environment 3. Describe how the complexity of the genome can accommodate (promote and constrain) the adaptation of different organisms (prokaryotes and eukaryotes) 4. Define evolutionary processes, such as selection at different organizational levels, genetic drift, and horizontal gene transfer 5. Assess how evolutionary processes affect genomic changes and can they be recognized at the genomic level 6. Asses how to use metagenomics to analyze complex prokaryotic communities 7. Design a project in which genomic tools are used to address ecological or evolutionary questions
Omschrijving	The aim of the course is to familiarize the student with the basic genetic principles and processes (like Mendelian genetics, inheritance patterns, linkage maps, population genetics and biotechnology) and to explain how the complexity of the genome of prokaryotes and eukaryotes, affects ecological and evolutionary processes at different levels. A central theme is how variation at the level of genotypes leads to variation in phenotypes, in interaction with environmental settings. Students will be familiar with population genetic processes such as mutation, genetic drift, horizontal gene transfer, migration and selection. They will learn how these processes at the genetic level can lead to evolutionary changes and constraints. They will learn that selection can act at different organizational levels, such as genic and individual selection. They will be instructed on metagenomics and genomic techniques and learn how these can be used in biotechnological research on prokaryotes and eukaryotes.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T) (LC-28 hrs; T-6 hrs; ASM-40 hrs (poster); Self study-66 hrs)
Toetsvorm	Opdracht (AST), Schriftelijk tentamen (WE) (Written exam 60% + poster presentation of AST 40%)
Vaksoort	bachelor
Coördinator	K.J. Tiedge, PhD.
Docent(en)	prof. dr. J.T.M. Elzenga , K.J. Tiedge, PhD.
Verplichte literatuur	Titel Auteur ISBN Prijs Biology, a Global Approach,12th edition Campbell et al 9781292341637
Entreevoorwaarden	Builds on knowledge from: Basic molecular genetics knowledge from year 1.
Opmerkingen	Dr. Tiedge is the course coordinator and should be contacted about organizational aspects. Prof. Elzenga will act as first examiner.
Opgenomen in	Opleiding Jaar Periode Type BSc Life Science and Technology 2 semester II b verplicht