Host-microbe Interactions

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WBLS19012
Vaknaam Host-microbe Interactions
Niveau(s) bachelor
Voertaal Engels
Periode semester I b

Uitgebreide vaknaam Host-microbe Interactions
Leerdoelen At the end of the course, the student is able to:
1. Outline the interaction between the diet, and gut microbes
2. Identify how gut microbes and their products interact with host cells
3. Discuss the role of interactions in host health and disease
4. Describe mechanisms of multidisciplinary dialogue between the microbiome,
immune response, and neuronal system
5. Apply the acquired information to solve research questions/case studies attributed to
the topic
6. Analyze microbiota composition data and demonstrate biological interpretation of
7. Develop critical view on the role of microbiome in human health
8. Use the acquired knowledge to design experiments about the microbiome- host
Omschrijving The course addresses advanced concepts in interactions between humans and their gut microbes (microbiota).

The course aims to:
• Provide emphasis on the host-microbiota interaction with a focus on the link between the gut microbiota, nutrition, health and disease.
• Provide multidisciplinary guidance in microbiology, nutrition, microbiota signaling, immunity, and neuroendocrinology.

Education on different aspects of the interaction between the microbiota and nutrition in health and disease. This will discuss a- how the nutrient flow shapes the microbiota and its metabolic profile, which in turn, drive the cross talk between the gut microbes with the host immune, gut-brain axis, metabolic systems, b- how to develop microbiota-based therapy through the manipulation of the microbial community (e.g. fecal transplantation, probiotics and prebiotics).

Course content:
1. Introduction to microbiome; oral, skin, and gut (composition and function). (El Aidy)
2. Metagenomic (pathway analysis) and Multi-omics bio-bank cohort analysis (Harmsen)
3. Early live microbiome (Harmsen + El Aidy)
4. Diet and Lifestyle and microbiome (El Aidy)
5. Small intestinal bacteria (link to oral microbiota), Cross feeding among the gut microbes (Harmsen)
6. Host immunity and microbiome (innate and adaptive) (El Aidy)
7. Microbiome and gut disorders (IBD). (Harmsen)
8. Auto-immune diseases (T1-diabetes, Rheumatoid arthritis, Asthma, Multiple sclerosis) (Harmsen)
9. Microbiome and the Gut-Brain axis (El Aidy)
10. Microbiome and neurodegenerative disorders (El Aidy)
11. Microbiome interventions, FMT Pre and Probiotics (Harmsen)
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
(LC-30 hrs, T-22 hrs: solving problems collaboratively; data analysis (incl. hours needed to complete the task), ASM: report, PRC-8hrs (incl. hours needed to complete the task), Self study-80 hrs)
Toetsvorm Meerkeuze toets (MC), Verslag (R)
(MC-80%, R-20%: The final score for the exam should be at least 5.5)
Vaksoort bachelor
Coördinator S. El Aidy, PhD.
Docent(en) S. El Aidy, PhD. ,dr. ir. H.J.M. Harmsen
Verplichte literatuur
Titel Auteur ISBN Prijs
Reader inducing all lectures slides outline.
Opmerkingen Tutorials are mandatory. In case of absence without prior permission and without a demonstrable valid reason, the practical cannot be completed.

The course prepares an understanding of the general concepts in Host- gut microbe interactions and provides skills usable for various majors (Biomedical Sciences, Behavior and Neurosciences). At the end of the course the students are expected to have an overview for the multidisciplinary interactions between the human being and its gut microbes
Opgenomen in
Opleiding Jaar Periode Type
BSc Biologie of LS&T: Major Biomedische Wetenschappen (cohort 2016 en 2017)  (Minor Biomedische Wetenschappen en Gedrag en Neurowetenschappen) 3 semester I b keuzegroep
BSc Biology: major Biomedical Sciences 2 semester I b verplicht
BSc Biology: major Integrative Biology 2 semester I b keuzegroep
BSc Biology: major Molecular Life Sciences 2 semester I b verplicht
BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester I b verplicht
BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester I b verplicht