Genes and Evolution

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WBLS19003
Vaknaam Genes and Evolution
Niveau(s) bachelor
Voertaal Engels
Periode semester I a

Uitgebreide vaknaam Genes and Evolution
Leerdoelen At the end of the course, the student is able to:
1. define and quantify genetic variation and explain its relevance to evolution; calculate allele and genotype frequencies, linkage equilibrium, Hardy-Weinberg proportions and simple extensions of these proportions and explain their
relevance 2. define and quantify genetic drift and discuss its consequences
3. analyse several scenarios of natural selection 
4. calculate and interpret results from F-statistics as a measure of population differentiation and inbreeding
5. defend and argue how evolutionary mechanisms affect genetic variation and phenotypic evolution
6. describe coalescence and phylogenetic processes and conduct and interpret advanced phylogenetic analyses
7. define concepts relevant to the relationship between gene trees and species trees, and the population genetic processes covered in this course unit
8. describe various mechanisms of molecular and genomic evolution and interpret simple examples of such mechanisms
Omschrijving The course unit will introduce students to population genetic processes in relation to
evolution on the microscale. These principles will be illustrated in computer practicals.
Students will also be introduced to neutral and adaptive evolution, as well as molecular and
genome evolution. Various advanced phylogenetic principles will be explained and illustrated
in computer practicals.
The topics covered in this course unit are:
– population genetic processes (mutation, genetic drift, migration and selection, random
mating, Hardy-Weinberg equilibrium, linkage, non-random mating, inbreeding)
– selection models (linear selection, overdominance, frequency-dependent selection, selection at various levels, complex selection)
– effects of population genetic processes on the dynamics of genetic variation
– fragmentation, gene flow/migration and genetic differentiation between populations (F-statistics)
– molecular and genomic evolution (intron-exon structure, gene duplication, concerted evolution, transposable elements)
– phylogenetic analysis (neutral theory, molecular clock, coalescence, speciation)
– molecular techniques (microsatellite analysis, analysis of genetic data and structure, DNA sequencing, QTL analysis)
Uren per week
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(Traditional lecture 24 hrs, Q&A lecture 2 hrs, Pen & paper problem solving 12 hrs, Wet-lab practical (experiment) 12 hrs, Computer practical 24 hrs)
Toetsvorm Opdracht (AST), Schriftelijk tentamen (WE)
(Grading is based on the results of the written Exam. Practicals will be graded pass or fail. To pass this course a pass mark is needed for all the practicals, and a grade higher than 5.5 for the written exam. Open book exam.)
Vaksoort bachelor
Coördinator prof. dr. B. Wertheim
Docent(en) prof. dr. L.W. Beukeboom ,dr. E. Geuverink ,dr. L.P.W.G.M. Jacobus Mgn Van De Zande ,prof. dr. B. Wertheim
Verplichte literatuur
Titel Auteur ISBN Prijs
Evolutionary Analysis, 5th edition, 2014 Herron & Freeman 1- 292- 06127 -8 €  70,00
digital handouts of lectures & articles
Opmerkingen The course units assumes prior knowlegde and skills, acquired from the following other course units and/or degree programmes :
- Genetics, Ecology & Evolution
- Evolutionary Ecology
- Research Skills in Ecology & Evolution

The course unit prepares for and provides skills usable in the course unit(s) or degree programme(s): Genes & Behaviour, Conservation Biology, Evolution and Development, Evolutionary and Ecological Genomics

All practicals (computer & wet-leb) are mandatory. There are no exemptions for students that do a re-sit for the course (i.e. that did not pass the written exam earlier):
they need to re-do the practicals & assignments, also if these were passed in an earlier edition of the course.
In case of illness or a fail to one practical part, there is an opportunity during the course for repair.

Capacity max: 80 students
Opgenomen in
Opleiding Jaar Periode Type
BSc Biologie of LS&T: Major Biomedische Wetenschappen (cohort 2016 en 2017)  (Minor Biomedische Wetenschappen en Gedrag en Neurowetenschappen) 3 semester I a keuzegroep
BSc Biologie: Major Ecologie & Evolutie (cohort 2016 en 2017)  (Minor Ecologie & Evolutie) 3 semester I a verplicht
BSc Biology: major Behaviour and Neurosciences 2 semester I a keuzegroep
BSc Biology: major Ecology and Evolution 2 semester I a verplicht
BSc Biology: major Integrative Biology 2 semester I a keuzegroep
BSc LS&T: major Behaviour and Neurosciences (cohort 2018 and 2019) 2 semester I a keuzegroep