Age research ERIBA

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WBLS14005
Vaknaam Age research ERIBA
Niveau(s) bachelor
Voertaal Nederlands
Periode semester II b

Uitgebreide vaknaam Molecular and genetic age research ERIBA
Leerdoelen Introduction to research strategies in molecular aspects of ageing and age-related diseases.

At the end of the course, the student is able to:
Learning outcomes (knowledge)
1. Formulate scientific questions and design experiments to address these questions.

Learning outcomes (skills and training):
2. Perform laboratory experiments by using the available research instruments and methodologies and interpret data/results.

3. Critically review and present scientific literature in the field of Age research.

4. Overview different topics in the field of experimental ageing research.

5. Present the results of the experiments in an oral scientific presentation.
Omschrijving Research topics cover a broad range of techniques and model systems for research on topics related to ageing, lifespan and age-related diseases. Topics may involve (stem) cells, yeast, worms, mice, and cover the biological processes of signal transduction, transcription, translation, post-translational modification, protein homeostasis, energy metabolism, chromosome biology, genetics and epigenetics. For more information, visit .

Students can choose a lab for performing a practical research course (two students per lab; first come, first serve); the coordinator may take final decisions about the distribution over the labs.

Students will obtain a broad overview of experimental ageing research by following the MOOC "Why do we age? The molecular mechanisms of ageing" and attending related workshops with the PI/tutors.
Uren per week 40
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(This is a practical research course and will involve lab work (212 h), literature study/journal club (8h), poster presentation (8h), and a MOOC course/workshop (12 hours))
Toetsvorm Opdracht (AST), Practisch werk (PR), Presentatie (P)
(Practical lab work (50%), paper analysis and presentation (20%), poster presentation of data/results (30%).)
Vaksoort bachelor
Coördinator prof. dr. C.F. Calkhoven
Docent(en) prof. dr. C.F. Calkhoven ,prof. dr. G. de Haan , Gastdocent(en)
Verplichte literatuur
Titel Auteur ISBN Prijs
Scientific publication for Journal Club.
Scientific literature and experiment protocols for lab project.
Entreevoorwaarden Voor het project van Dr. V. Guryev geldt een ingangseis, zie opmerkingen.

The courses within the bachelor programmes Biology and Life Science & Technology are open to students of those degree programmes only. Students from other degree programmes may be unenrolled. Please contact the academic advisors of Biology/LST first.
Opmerkingen Presence during all parts of the course, laboratory work, literature presentation (journal club), MOOC lectures and workshop, and end-presentation is mandatory. In consultation with the supervisor and coordinator rearrangements can be made in specific cases.

Capacity: 16 students (+2 for the project by Dr. V. Guryev)

participating researchers/groups:
Prof. E. Berezikov - Molecular mechanism of regeneration and ageing in the flatworm M. lignano.
Prof. C.F. Calkhoven - Molecular aspects of cancer, metabolism and ageing.
Dr. M. Chang - Telomeres, genome stability, yeast ageing
Dr. M. Demaria - Cellular senescence in aging and age-related pathologies
Dr. F. Foijer - Mouse models for chromosomal instability: the relationship between cancer, ageing and chromosome copy number changes
Dr. V. Guryev - Genome Structure Ageing
Prof. G. de Haan - Selfrenewal mechanisms of hematopoietic stem cells.
Prof. E. Nollen - Molecular mechanisms of age-related neurodegenerative diseases.
Dr. J. Paridaen - Regulation of Stem Cell Decisions in Development and Ageing.
Dr. L. Veenhoff - Nuclear transport during replicative ageing.

For more detailed information on the projects, like what lab techniques will be used, students can contact the course coordinator, prof. dr. Calkhoven.

No special knowledge is recommended for most of the projects. However, only for topics under supervision of Dr. V. Guryev, who works on bioinformatic aspects of ageing, having taken one or more of the following courses is strongly recommended: Programmeren Lw or Wiskunde Lw or Humane genetica en genomics or Bioinformatica or Computational molecular biology research.
Opgenomen in
Opleiding Jaar Periode Type
BSc Biologie of LS&T: Major Biomedische Wetenschappen (cohort 2016 en 2017)  (Biomedische Wetenschappen) 3 semester II b bach. onderz.