Bioanalysis

Uitgebreide vaknaam	Bioanalysis
Leerdoelen	At the end of the course, the student is able to: 1) understand the theoretical background of the following methods: liquid chromatography, gel electrophoresis, mass spectrometry, ligand binding assays,liquid-liquid extractions, protein analysis including the analysis of biopharmaceuticals 2) understand the fundamental principles of toxicological analysis, therapeutic drug monitoring, clinical chemistry and the interpretation of laboratory data 3) design experiments related to the quantitative analysis of drugs and of therapeutic proteins (biopharmaceuticals) in body fluids and outline the validation of such methods according to international guidelines 4) develop simple separation- and mass spectrometry-based methods for specific real-life problems 5) execute quantitative and qualitative analyses of drugs and proteins in biological samples with applications in clinical chemistry, therapeutic drug monitoring and clinical toxicology 6) select an appropriate analytical method and interpret the results based on arguments showing that they can apply the acquired theoretical and practical knowledge to problems in pharmaceutical analysis and bioanalysis 7) become aware of application areas of (bio)analytical chemistry related to drug analysis/monitoring and clinical chemistry 8) understand the theoretical principles of the interpretation of the data obtained in a clinical chemistry laboratory 9) understand how quantitative drug analyses can be used to optimize drug treatment 10) interpret the results of toxicological analyses by using simple pharmacokinetic calculations.
Omschrijving	The following topics will be treated in this course: Theory: Introduction to Bioanalysis, Sample Preparation, Separation Methods, Ligand Binding Assays, Mass Spectrometry, Protein Analysis, Biopharmaceuticals, Regulated Bioanalysis, Applied Pharmacokinetics, Therapeutic Drug Monitoring and Toxicology, Clinical Chemistry, Interpretation of Laboratory Data Practical Part: Sample Preparation, Protein Analysis, Drug Analysis in Biological Samples This course is based on prior knowledge from the course Instrumental Analysis. This course prepares students for the following courses: Advanced Bioanalysis (elective course in the 3rd year), Quantitative Bioanalysis, research in this field, as well as for a Masters in Pharmacy or Medical Pharmaceutical Sciences.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T) (lectures: 12 hrs; tutorial: 8 hrs; practical: 40 hrs; assignment: 40 hrs; self study: 40 hrs)
Toetsvorm	Mondeling tentamen (OR), Practisch werk (PR), Schriftelijk tentamen (WE), Verslag (R) (Written exam (50%); Oral exam ("voor- en nabespreking") (30%); Report (15%); Practical (5%). Students must pass both the written exam and the practical. The final grade is constituted of the following parts: Written Exam: 50% Practical: 50%)
Vaksoort	bachelor
Coördinator	prof. dr. P.L. Horvatovich
Docent(en)	dr. D.A.J. Dijck-Brouwer ,prof. dr. P.L. Horvatovich , P.H.M. Le, PhD. ,prof. dr. D.J. Touw ,prof. dr. N.C. van de Merbel
Verplichte literatuur	Titel Auteur ISBN Prijs Reader (mandatory): Bioanalysis Rainer Bischoff Daan Touw Janneke Dijck-Brouwer Nico C. van de Merbel n.a. Reader (mandatory): Instruction Manual for Practical Work Jan Willem Meints & Jennifer Le Book: Quantitative Chemical Analysis (9th edition) Daniel C. Harris 9781319154141 Handouts (mandatory): Slides of Lectures (with voice over) Rainer Bischoff Daan Touw Janneke Dijck-Brouwer Nico C. van de Merbel Film: (https://www.youtube.com/watch?v=ekFtgf20lhk) Rainer Bischoff Daan Touw Janneke Dijck-Brouwer Nico C. van de Merbel colleagues and coworkers
Entreevoorwaarden	Students who want to participate need to have followed the course Pharmaceutical Analysis.
Opmerkingen	The capacity of this course unit is 150 participants. Students must be present during the introductory lecture (first lecture of the course). Absence without notification means removal from the course unit. Students must be present during the practical. Students must pass both the written exam and the practicum. The final grade is constituted of the following parts: Written Exam: 50% Practicum: 50% Updated 05-05-2021 LW
Opgenomen in	Opleiding Jaar Periode Type BSc Pharmacy  (hoofdprogramma) 2 semester II b verplicht