Pharmacokinetics

Uitgebreide vaknaam	Pharmacokinetics
Leerdoelen	At the end of the course, the student is able to: 1. describe the mechanisms of basic physiological and pharmacokinetic processes: absorption, distribution, elimination, renal excretion and hepatic clearance 2. describe and recognize the plasma concentration-time and excretion-time curves of drugs after intravenous injection, continuous infusion and extravascular administration, and the plasma concentration time curve after multiple intravenous administrations 3. calculate the pharmacokinetic parameters from the plasma concentration time curve and renal excretion of drugs by using pharmacokinetic analysis 4. make dosage calculations on the basis of multiple administration of drug 5. recognize, describe and analyze plasma concentration-time curves of drugs following 1 and 2 compartment kinetics 6. discuss and use the connections between pharmacokinetic processes and parameters 7. explain the effect of changes in physiological and pathological processes on the pharmacokinetic parameters, the plasma concentration time curve and the correct dosage of drugs 8. conduct a few experiments relating to pharmacokinetics, and to interpret and report on the results. 9. analyse, calculate and explain typical pharmacokinetic issues in hospital and community pharmacy related cases
Omschrijving	This course covers the following topics Theoretical: - the basic mechanisms and physiological background of pharmacokinetic processes: absorption, distribution, elimination, renal and hepatic elimination; - the plasma concentration-time curve and renal excretion of drugs after intravenous injection, constant-rate infusion, extravascular administration and multiple-dose intravenous administration; - the calculation of the pharmacokinetic parameters from the plasma concentration-time curve and renal excretion of drugs; - the calculation of dosage for single and multiple-dose administration of drugs; - the relation between pharmacokinetic processes and parameters; - the effect of changes in physiological and pathological processes on the pharmacokinetic parameters, the plasma concentration-time curve and the correct dosage of drugs; - Pharmacokinetic case studies of the general and hospital pharmacy practice Practicals: - Absorption: paracetamol in humans; - Infusion kinetics: glassman patient: - Distribution and elimination: drug targeting
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC) (30 hours of lectures, 33 hours of practicals, 30 hours of assignments, 47 hours of self study.)
Toetsvorm	Practisch werk (PR), Schriftelijk tentamen (WE), Tussentoets (IT), Verslag (R) (The report is assessed as part of the practical work and the interim test (SOWISO exercises) together with the written exam. For each part, a (partial) grade is given. The partial grade is not rounded off. To pass the course, each partial grade has to be >= 5.5. The final grade is the weighted average of the partial grades, with the practicals counting for 35% and the written exam for 65%.)
Vaksoort	bachelor
Coördinator	P.H.C. Åberg, PhD.
Docent(en)	P.H.C. Åberg, PhD. , M. Balogh, PhD. ,ing. E. Post ,prof. dr. D.J. Touw
Verplichte literatuur	Titel Auteur ISBN Prijs Clinical Pharmacokinetics and Pharmacodynamics (5th Ed) Rowland M, Tozer TN 9781496385048 €  89,00
Entreevoorwaarden	A pass in the following course units: Physiology & Pharmacology.
Opmerkingen	Presence during the following parts of the course is mandatory: Introductory lecture, "Introduction to practicals" lecture and practicals.
Opgenomen in	Opleiding Jaar Periode Type BSc Farmacie  (hoofdprogramma) 2 semester I b verplicht BSc Life Science and Technology  (Specialisation - Medical Pharmaceutical Sciences) 3 semester I b verplicht Pre-master/Fast-track for MSc Pharmacy - MPS - semester I b verplicht