Medicinal Chemistry 1

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WBCH003-05
Vaknaam Medicinal Chemistry 1
Niveau(s) bachelor
Voertaal Engels
Periode semester I a
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Medicinal Chemistry 1
Leerdoelen Upon completion of this course:
1. Describe and explain the main steps and principles of the methods discussed in the course
2. Explain what defines a good drug and drug target
3. Define the 3D topology of drug molecules based on their 2D chemical structures
4. Identify protein-ligand interactions and explain their contributions to drug binding and specificity, using information from 3D structures and functional assays.
5. Explain (and calculate) how changes in a drug, drug-target and their environment influence ligand binding
6. Discuss the quality of a crystallographic data set and the associated protein structure (electron density, symmetry, statistical data qualifiers, structure validation)
7. Evaluate and discuss the outcome of a drug docking procedures
Omschrijving The course presents an overview of structural biology and structural bioinformatics, focusing on their use in drug discovery and design. Special attention will be given to the determination, assessment and analysis of 3D protein structures and protein-ligand interactions. Relevant case examples examples (e.g. HIV protease inhibitors, ACE inhibitors, drugs against adrenergic receptors)will be presented to illustrate how structural biology can accelerate drug discovery. Besides lectures, the course will also include two interactive computer practicals/tutorials to allow a better understanding of how methods in structural biology/structural bioinformatics work and are carried out.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm Schriftelijk tentamen (WE), Verslag (R)
(Final mark: Written exam (75%), Report (25%). See remarks.)
Vaksoort bachelor
Coördinator dr. A.M.W.H. Thunnissen
Docent(en) dr. A.M.W.H. Thunnissen
Verplichte literatuur
Titel Auteur ISBN Prijs
Title: An Introduction to Medicinal Chemistry (2017, 6th edition, Oxford University Press) Graham L. Patrick 978-0-19-874969-1 €  45,00
Handouts of lecture slides, questions and exercises, copies of scientific papers, manuals for computer tutorials and assignments, all available via Nestor
Entreevoorwaarden
Opmerkingen Written exam grade needs to be 5.5 or higher
Report grade needs to be 5 or higher

This course was registered last year with course code CHMC1-12
Opgenomen in
Opleiding Jaar Periode Type
BSc Chemical Engineering 3 semester I a keuze
BSc Chemistry  (Core programme ) 3 semester I a keuze
BSc Courses for Exchange Students: Chemistry - Chemical Engineering - semester I a