Bioanalytical and Omics Techniques

Uitgebreide vaknaam	Bioanalytical and Omics Techniques
Leerdoelen	At the end of the course, the student is able to: 1) describe and explain the basic principles, applications, advantages and limitations of the bioanalytical and omics techniques discussed in this course 2) explain how data are analysed and interpreted in the bioanalytical and omics techniques discussed in this course 3) identify and explain the methodology and data analysis applied in omics-related scientific papers 4) describe and motivate which bioanalytical methods are suitable to address specific questions in omics-related research
Omschrijving	This course aims to provide students with a better understanding of the main principles and applications of various bio-analytical and omics techniques in life science research. Subjects covered in the course include: - General principles of genomics, transcriptomics, proteomics, metabolomics and interactomics - Genomics and protein-DNA interactions: DNA-microarrays, EMSA, DNAse footprinting, Chip-seq, yeast2hybrid - Proteomics and metabolomics: sample preparation methods, mass spectrometry methods, bioinformatics - Interactomics and protein-protein interactions: complex pull down, co-immunoprecipitation, fluorescence-based methods, cross-linking, protein arrays, protein-fragment complementation Subjects will be explained in a number of lectures and seminars, augmented by computer tutorials. In addition, students will receive group assignments to study from selected scientific publications a specific set of techniques in more detail (find out why and how they are applied, how data are analyzed, what are the advantages and limitations) and give a presentation on their findings.
Uren per week
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM), Werkcollege (T) (LC-24 hrs; S-12 hrs; T-8 hrs; ASM-10 hrs; Self-study-86 hrs)
Toetsvorm	Presentatie (P), Schriftelijk tentamen (WE) (WE-60%; P-40% (Both grades, for the exam and presentation, need to be 5.5 or higher.))
Vaksoort	bachelor
Coördinator	dr. A.M.W.H. Thunnissen
Docent(en)	prof. dr. O.P. Kuipers ,dr. H.P. Permentier ,dr. A.M.W.H. Thunnissen
Verplichte literatuur	Titel Auteur ISBN Prijs Scientific papers, lecture slides and tutorials will be digitally provided via the Student Portal
Entreevoorwaarden	Molecular Genetics, Bioinformatics, Molecules of Life, Basic Cell and Molecular Biology PLEASE NOTE Students from other degree programmes than Biology and/or Life Science & Technology who would like to participate in this course unit are obliged to contact one of the academic advisors of the BSc. Biology before enrolling in this course in order to check whether they have meet de entrance requirements. After this contact, students also have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this entire procedure before the official enrollment deadline, results in immediate unenrollment without prior notification. Students from the Bachelor's degree programmes Biology and Life Science & Technology take priority over students from other degree programmes when the course has a maximum capacity.
Opmerkingen	All classes, including seminars, tutorials and student presentations, are mandatory. If a class cannot be attended, the student needs to notify teacher or course coordinator stating the reason of absence. Unexcused absences may result in exclusion from the exam. Missed assignments will have to be carried out at a later time.
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Molecular Life Sciences 3 semester II a keuzegroep BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 3 semester II a keuzegroep BSc Life Science and Technology  (Specialisation - Biomolecular Sciences) 3 semester II a verplicht