Cell Migration and Communication

Uitgebreide vaknaam	Cell Migration and Communication
Leerdoelen	At the end of the course, the student is able to: 1) describe the structure of biological membranes, including lipids and general features of membrane proteins 2) explain the different gating mechanisms of channel proteins and explain the structural basis for the ion selectivity of channel proteins 3) explain electrophysiology methods to probe the activity of channel proteins and explain the mechanisms by which transporters generate electrochemical gradients 4) explain the role of ion channels in the propagation of nerve impulses in neurons 5) explain the nature of signals, the nature of receptors and the nature of intracellular downstream signaling cascades 6) describe the molecular concepts behind signal specificity, signal amplification, signal adaptation and signal integration 7) explain how various sensing capabilities (smell, vision, chemical gradients) function in molecular detail 8) compare the composition, assembly and dynamics of microfilaments, microtubules and intermediate filaments at the molecular level, and can apply this knowledge to describe and explain the different functions of these three types of cytoskeletal filaments in cell morphology, transport and migration. 9) distinguish the most common families of adhesion complexes at the level of general molecular structure, function and interactions with both cytoskeleton and extracellular matrix. 10) the student knows the main families of extracellular matrix molecules and can associate the overall molecular structure of these molecules with their functions in cell behaviour and tissue organization.
Omschrijving	The aim of this course is to integrate knowledge from previous courses in order to achieve a more thorough molecular understanding of complex biological systems and behaviour. Signal transduction in membranes: Deepen the understanding of the concepts of channels and the electrical properties of membranes. An overview will be provided of the different gating mechanisms of channel proteins, the electrophysiology methods to probe the activity of channel proteins, the structural basis for the ion selectivity of channel proteins and the role of ion channels in the propagation of nerve impulses in neurons. The lectures also provide an overview of the structure and dynamics of biological membranes, and the mechanisms of solute and ion transport in generating electrochemical gradients. Receptors and Signal transduction: How can cells sense their environment and process incoming signals precisely. An overview will be provided of receptor classes and concepts of signal transduction and integration. Major classes of transmembrane and nuclear receptors in eukaryotes and bacteria will be discussed. Molecular concepts of downstream signaling in time and space, signal amplification, signal specificity and signal adaptation will be discussed. Molecular details of smell and vision (eukaryotic systems) as well as sensing of chemical gradients (chemotaxis in bacteria) will be discussed. The cytoskeleton and extracellular matrix: The composition, assembly and dynamics of cytoskeleton,as well as the function and regulation of actin, microtubules and intermediate filaments in cell organization, polarization and migration will be discussed. The main groups of cell-cell adhesion complexes will be discussed with a focus on epithelial cells. An overview of the main families of extracellular matrix will be provided, and their roles in cell behavior and tissue organization will be addressed. The protein complexes that mediate cell adhesion to extracellular matrix will be discussed.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T) (Traditional lecture 24 hrs, Discussion (and/or quiz) about reading assignments 6 hrs, Selfstudy: Reading/reviewing/learning assigned book chapters, and reading and explaining review/research papers)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE) (a) obtain a score of at least 55% for the multiple choice test (after error correction) AND b) obtain a score of at least 55% for the open question test)
Vaksoort	bachelor
Coördinator	dr. M.H.K. Linskens
Docent(en)	S.K. Billerbeck, PhD. ,prof. dr. B. Poolman ,prof. dr. G. van den Bogaart
Verplichte literatuur	Titel Auteur ISBN Prijs Molecular Biology of the Cell, 6th edition Alberts et al
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Molecular Life Sciences 2 semester II a verplicht BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester II a verplicht