Microbes and Infection

Uitgebreide vaknaam	Microbes and Infection
Leerdoelen	At the end of the course, the student is able to: 1) Describe the structure and the life cycle of pathogenic micro-organisms and the diversity among the different species. 2) Discuss the interaction of pathogenic micro-organisms with other micro-organisms and their eukaryotic host. 3) Summarize the pathogenesis of infections with micro-organisms in general and explain this for pathogenic microorganisms discussed during the lectures. 4) Describe for a disease-associated micro-organisms the mode of transmission, methods for diagnostics, prevention and treatment options. 5) Explain for discussed micro-organisms the mechanism by which antibiotics or antiviral drugs affect the replication cycle. 6) Compare different types of vaccines and their mode of action. 7) Summarize the medical microbiological background of a number of "public health" problems such as: antibiotic resistance, pandemics, vaccination, treatment versus prevention. 8) Apply different techniques to identify, characterize and determine the drug resistance of bacteria and viruses for diagnostics. 9) Keep a lab journal in which experiments, analysis, results and conclusions are described according to standard. 10) Analyze and interpret the results of an experiment and report on the results and conclusions in form of a scientific abstract/report.
Omschrijving	This course will focus on infectious micro-organisms, how they cause disease in the human host, and how infectious diseases can be diagnosed, treated and prevented. Bacterial, viral, fungal and parasitic pathogens, their biology, origin and epidemiology, the host responses to these micro-organisms, and the consequences of the infection for the human host will be discussed. Important topics for the future control of infectious disease like vaccination and the problem of antibiotic resistance will also be covered. The course consists of a series of theoretical lectures and a practical part involving digital as well as laboratory experiments. In the practical part, students will gain insight in genomics and diagnostics of viral and bacterial infections, such as SARS-CoV-2. Additionally, experiments will cover the characterization of bacteria and viruses, investigation of virulence factors and determination of vaccine-induced immune responses. Next to acquiring theoretical and practical knowledge, students will train their scientific writing skills by writing an abstract. In case, the practical cannot be given in a laboratory (as was the case in 2021) the practical part will consist of digital assignments mimicking laboratory experiments.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T) (LC-24hr, T-12hrs, ASM 2x4 hrs, PRC-30hrs, self-study 66 hrs)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR), Verslag (R) (MC-70%, R-15%, PR1-10%, PR2-5%)
Vaksoort	bachelor
Coördinator	prof. dr. A.L.W. Huckriede
Docent(en)	Guest lecturer ,dr. ir. H.J.M. Harmsen ,prof. dr. J.M. Smit ,prof. dr. J.M. van Dijl
Verplichte literatuur	Titel Auteur ISBN Prijs Labguide (via Google platform) 2022 Lecturers Medical Microbiology and Infection prevention Video lectures (available via Nestor) Lecturers Medical Microbiology and Infection prevention Course content including all lecture slides (available via Nestor) Lecturers Medical Microbiology and Infection prevention Medical Microbiology (9th ed., 2021) P.R.Murray, K.S.Rosenthal and M.A. Pfaller 9780323673228 €  74,00 E-book: Medical Microbiology via: http://rug.on.worldcat.org/ 9th 2021 P.R.Murray, K.S.Rosenthal and M.A. Pfaller 9780323673228 €  6,20 Live Q&A sessions Lecturers Medical Microbiology and Infection prevention
Entreevoorwaarden	Prior knowledge: Basic Cell & Molecular Biology, Physiology, Genetics, Microbiology, Lab course, Molecules of Life, Cell Biology & Immunology, Biochemistry & Cell Biology, Research Skills in Life Sciences, Immunology, Host Microbe Interaction Students are not allowed to follow the course "Microbes and Infection" (WBBY059-05) when they have already passed the course "Medical Microbiology / Medische Microbiologie" (WBBE006-05 / WLB0703). PLEASE NOTE This course unit is only accessible to students enrolled in the Bachelor's programmes Biology or old curriculum Life Science & Technology. Students following other degree programmes cannot follow this course unit and will be unenrolled in Progress.
Opmerkingen	Guest lecturers: lecturers of the department Medical Microbiology and Infection prevention. Capacity max: 80 students The course grade is calculated as follows: course grade = 0.7* mark exam + 0.3* mark practical where mark practical is calculated as 0.15*mark abstract + 0.1*mark lab journal + 0.05*mark assignments. The mark for the exam must at least be a 5.00, the final score for the practical at least 5.50 to pass the course. In case the course has to be repeated, the partial grade for the practical obtained earlier remains valid. Participation during the practical is mandatory. In case of absence without prior permission and without a demonstrable valid reason, the practical cannot be completed. In case the practical has to be replaced by a digital assignment mimicking laboratory experiments the final grade will be built up as follows: Multiple choice exam 70%, Writing scientific assignment 15%, digital assignments 15%.
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Behaviour and Neurosciences 2 semester II a keuze BSc Biology: major Biomedical Sciences 2 semester II a keuze BSc Biology: major Molecular Life Sciences 3 semester II a keuze BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 3 semester II a keuze