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Microbes and Infection
| Faculteit | Science and Engineering |
| Jaar | 2020/21 |
| Vakcode | WBBY059-05 |
| Vaknaam | Microbes and Infection |
| Niveau(s) | bachelor |
| Voertaal | Engels |
| Periode | semester II a |
| ECTS | 5 |
| Rooster | rooster.rug.nl |
| Uitgebreide vaknaam | Microbes and Infection | ||||||||||||||||||||||||
| Leerdoelen | At the end of the course, the student is able to: 1) Describe the structure and the life cycle of pathogenic micro-organisms and the diversity among the different species. 2) Discuss the interaction of pathogenic micro-organisms with other micro-organisms and their eukaryotic host. 3) Summarize the pathogenesis of infections with micro-organisms in general and explain this for pathogenic microorganisms discussed during the lectures. 4) Describe for a disease-associated micro-organisms the mode of transmission, methods for diagnostics, prevention and treatment options. 5) Explain for discussed micro-organisms the mechanism by which antibiotics or antiviral drugs affect the replication cycle. 6) Compare different types of vaccines and their mode of action. 7) Summarize the medical microbiological background of a number of "public health" problems such as: antibiotic resistance, pandemics, vaccination, treatment versus prevention. 8) Apply different techniques to identify, characterize and determine the drug resistance of bacteria and viruses for diagnostics. 9) Keep a lab journal in which experiments, analysis, results and conclusion are described according to standard. 10) Analyze the results of an experiment and report on the results and conclusions in form of a scientific abstract/report. |
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| Omschrijving | The course consists of a theoretical and a practical part. Theoretical part: The lectures will cover a range of medical aspects of microbiology, such as the structure and classification of bacteria and viruses, replication mechanisms of bacteria and viruses, virulence factors, pathogenesis, relationship with diseases, diagnosis of infectious microorganisms, specific bacterial and viral diseases, zoonosis, prevention (vaccination), antibiotic use and resistance development, antivirals. Practical part: Bacteriology: Use of techniques for identification of pathogenic bacteria, determination of bacteria in a mixture. Detection of the regulation and action of different virulence factors. Determination of antibiotic resistance development of different bacterial strains and analysis of the exchange of genetic material responsible for resistance development. Use of genetic analysis for subtyping of potential pathogenic microorganisms within a species. Virology: Investigation of students’ throat swaps for presence of Epstein Barr virus. Performing a hemagglutination and hemagglutination inhibition assay for determination of virus and antibody titers to influenza virus. Use of quantitative PCR for the determination of a viral load.
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| Uren per week | |||||||||||||||||||||||||
| Onderwijsvorm |
Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
(Regular lectures 20 hrs, Blended lectures 4 hrs, Preparation lab work 12 hrs, Writing abstract 4 hrs, Complete workup sheets 4 hrs, Practical work 30 hrs, Self study 66 hrs) |
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| Toetsvorm |
Meerkeuze toets (MC), Practisch werk (PR), Verslag (R)
(The course rating is calculated as follows: course rating = (3T + 2P)/5 where T = mark for the exam and P = calculated as follows: P = (PW + A)/2 where PW = mark for practical work, A = mark for abstract. The mark for the exam must at least be a 5.00 to pass the course. The final score for the practical should be at least 5.50. The final score for the course should be at least 5.50.) |
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| Vaksoort | bachelor | ||||||||||||||||||||||||
| Coördinator | prof. dr. J.M. Smit | ||||||||||||||||||||||||
| Docent(en) | dr. ing. G. Buist , Gastdocent(en) ,dr. ir. H.J.M. Harmsen ,prof. dr. A.L.W. Huckriede ,prof. dr. J.M. Smit | ||||||||||||||||||||||||
| Verplichte literatuur |
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| Entreevoorwaarden | Prior knowledge: Basic Cell & Molecular Biology, Physiology, Genetics, Ecology & Evolution Microbiology, Labcourse, Biostatistics 1 Behavioural Neuroscience, Molecules of Life, Cell Biology & Immunology, Biochemistry & Cell Biology, Metabolism. Students are not allowed to follow the course "Microbes and Infection" (WBBY059-05) when they have already passed the course "Medical Microbiology / Medische Microbiologie" (WBBE006-05 / WLB0703). PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification. |
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| Opmerkingen | Guest lecturers: lecturers of the department Medical Microbiology and Infection prevention. Capacity max: 80 students Participation during the practical is mandatory. In case of absence without prior permission and without a valid reason, the practical cannot be completed and no mark will be given. In case the practical has to be replaced by a digital assignment mimicking laboratory experiments the final grade will be built up as follows: Multiple choice exam 70%, Writing scientific assignment 20%, digital assignments 10%. Dit vak had vorig jaar vakcode WBLS19041 |
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