Enzymology and Thermodynamics

Uitgebreide vaknaam	Enzymology and Thermodynamics
Leerdoelen	At the end of the course, the student is able to: 1) Explain what thermodynamic quantities such as internal energy, enthalpy, entropy, free energy, entail, and explain the relevance of free energy for biological processes 2) Explain the correlation and interaction between thermodynamic quantities including free energy, redox potential and thermodynamic potential. 3) To derive the course of a chemical reaction in time from the rate equation, and vice versa 4) To explain the relation between chemical and enzyme kinetics 5) To work out kinetic schemes for simple enzyme catalyzed reactions and to derive rate equations
Omschrijving	The course unit consists of the components thermodynamics and reaction kinetics. Both parts are based on the basic concepts of physical chemistry, which are then developed within the context of biological systems. Thermodynamics starts by studying the overall picture of internal energy and the first law of thermodynamics, based on forms of energy, work and heat. Chemical reactions and thermodynamic techniques (e.g. the standard state) are introduced by means of enthalpy. The second law of thermodynamics as well as entropy and free energy are studied by looking at processes in biological systems. The reaction kinetics component first considers basic concepts such as reaction speed, rate law, rate constant, rate equation and transition state. The concept of catalysis is then used to define the rate equation of an enzyme-catalysed reaction.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T) (Interactive lecture 18 hrs, Questions session 2 hrs, Exercises (problem solving) 16 hrs, Self study 104 hrs.)
Toetsvorm	Schriftelijk tentamen (WE) (55% score on exam)
Vaksoort	bachelor
Coördinator	prof. dr. D.J. Slotboom
Docent(en)	prof. dr. G. Maglia, PhD. ,prof. dr. D.J. Slotboom
Verplichte literatuur	Titel Auteur ISBN Prijs Physical Chemistry for the Life Sciences, Freeman/Oxford University Press 2 2011 Peter Atkins and Julio de Paula Practice exam (Nestor) Tutorial questions (Nestor) Syllabus thermody namic potential (Nestor)
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : Molecules of life, Metabolism, Basic cell and molecular biology, Biostatistics 1 PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The course unit prepares for and provides skills usable in the course unit(s) or degree programme(s): BSc research project in Biochemistry/Enzymology, MSc programs in Molecular Biology and Chemical Biology Dit vak had vorig jaar vakcode WBLS19036
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Molecular Life Sciences 2 semester II b verplicht BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester II b verplicht