Enzymology and Thermodynamics

Uitgebreide vaknaam	Enzymology and Thermodynamics
Leerdoelen	At the end of the course, the student is able to: 1) To explain what thermodynamic quantities such as internal energy, enthalpy, entropy, free energy, entail (qualitative), and apply this knowledge in calculations (quantitative) 2) To explain the relevance of free energy for biological processes 3) To explain the correlation and interaction between thermodynamic quantities including free energy, redox potential and thermodynamic potential. 4) To derive the course of a chemical reaction in time from the rate equation, and vice versa 5) To explain the relation between chemical and enzyme kinetics 6) To work out kinetic schemes for simple enzyme catalyzed reactions and to interpret the derived rate equations
Omschrijving	The course unit consists of the components thermodynamics and reaction kinetics. Both parts are based on the basic concepts of physical chemistry, which are then developed within the context of biological systems. Thermodynamics starts by studying the overall picture of internal energy and the first law of thermodynamics, based on forms of energy, work and heat. Chemical reactions and thermodynamic techniques (e.g. the standard state) are introduced by means of enthalpy. The second law of thermodynamics as well as entropy and free energy are studied by looking at processes in biological systems. The reaction kinetics component first considers basic concepts such as reaction speed, rate law, rate constant, rate equation and transition state. The concept of catalysis is then used to define the rate equation of an enzyme-catalysed reaction.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T) (LC-24hrs, T-18hrs, self-study 98 hrs)
Toetsvorm	Schriftelijk tentamen (WE) (WE-100%. Pass mark: 55% score on exam)
Vaksoort	bachelor
Coördinator	prof. dr. D.J. Slotboom
Docent(en)	Prof. Dr. G. Maglia, PhD. ,prof. dr. D.J. Slotboom
Verplichte literatuur	Titel Auteur ISBN Prijs Tutorial questions (Nestor) Syllabus thermody namic potential (Nestor) Physical Chemistry for the Life Sciences, Freeman/Oxford University Press 2 2011 Peter Atkins and Julio de Paula Practice exam (Nestor)
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : Molecules of life, Metabolism, Basic cell and molecular biology, Biostatistics 1, Modelling Life PLEASE NOTE Students from other degree programmes than Biology and/or Life Science & Technology who would like to participate in this course unit need to have basic knowledge of biochemistry and mathematics (wiskunde b). Students are obliged to contact one of the academic advisors before enrolling in this course in order to check whether they have met de entrance requirements. After this contact, students also have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this entire procedure before the official enrollment deadline, results in immediate unenrollment without prior notification. Students from the Bachelor's degree programmes Biology and Life Science & Technology take priority over students from other degree programmes when the course has a maximum capacity.
Opmerkingen
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Molecular Life Sciences 2 semester II b verplicht Pre-master/Fast-track for MSc BCN - Biology - BMS - semester II b verplicht