Biology of Cancer

Uitgebreide vaknaam	Biology of Cancer
Leerdoelen	At the end of the course, the student is able to: 1) To describe, discuss and distinguish models of carcinogenesis. 2) To describe, discuss and distinguish molecular pathways in different cancer types and how these pathways can be targeted. 3) To describe, analyse and evaluate regulation of these pathways at an (epi) genetic level. 4) To describe, discuss and distinguish mechanisms of action of classic chemotherapeutic drugs and novel targeted drugs and to integrate this knowledge to choose relevant preclinical models 5) Use publicly available data to investigate oncogenes and tumor suppressor genes and be able to compare their function in normal and tumor tissue and select therapeutic strategies 6) To create a poster and defend the content. 7) To assess posters and to evaluate quality of posters 8) To assess and compare co-workers within their own poster group
Omschrijving	During this course we will discuss in the lectures: carcinogenesis, cancer stem cells, the role of oncogenes and tumor suppressor genes, the large variety of subtypes within hematological and solid tumors, the signaling pathways active in different tumor types, genetic regulation of these molecular pathways (epigenetics, miRNA), DNA damage response, the tumormicroenvironment , the process of metastasis, tumor immunology, therapeutic strategies to inhibit tumor growth, development of cancer drugs, development of clinically relevant cancer models, and clinical cancer research. Each group of 4-5 students will investigate an interesting oncogene or tumor suppressor gene using publicly available databases. Normal function of the gene of interest, its role in cancer, in which cancer type the gene plays a role, which mutations are found in this cancer gene and how we can use this knowledge for treatment strategies. Results are presented during a poster session.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T) (Lectures 20 hrs, tutorials 6 hrs, assignments 31 hrs)
Toetsvorm	Meerkeuze toets (MC), Presentatie (P) (MC: 70%, poster presentation: 30%. Multiple choice exam 5 or higher (70%), poster and presentation 5 or higher (30%). Total 5.5 or higher. Poster mark is based upon supervisor (50%) and two poster groups and their supervisor (25% + 25%). Judgement of other group members can result in +1 or -1 point of the average mark for a poster group.)
Vaksoort	bachelor
Coördinator	prof. dr. S. de Jong
Docent(en)	dr. M. de Bruyn ,dr. R.S.N. Fehrmann ,prof. dr. F.A.E. Kruyt , Other lecturers ,prof. dr. K. Poelstra ,prof. dr. J.J. Schuringa ,dr. G.B.A. Schuurs-Wisman ,prof. dr. M.A.T.M. van Vugt
Verplichte literatuur	Titel Auteur ISBN Prijs The Biology of Cancer (2nd ed, 2013) - Robert A. Weinberg ca. €  70,00
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : Basic Cell and Molecular Biology PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Other lecturers: Prof. Anke van den Berg. First lecture and introduction poster activity are mandatory. Students have to report and explain their absence, otherwise they are not being registered as participant. This will allow other students to gain access to the course. Poster presentation is mandatory. Absence without notificating: no mark. With notification, they have to present the poster at another time. Capacity max: 100 Dit vak had vorig jaar vakcode WBLS19017
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Biomedical Sciences 2 semester II a keuze BSc Biology: major Molecular Life Sciences 3 semester II a keuze BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester II a keuze BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 3 semester II a keuze