Host-microbe Interactions

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WBBY019-05
Vaknaam Host-microbe Interactions
Niveau(s) bachelor
Voertaal Engels
Periode semester I b

Uitgebreide vaknaam Host-microbe Interactions
Leerdoelen At the end of the course, the student is able to:
1. Outline the interaction between the diet, and gut microbes
2. Identify how gut microbes and their products interact with host cells
3. Discuss the role of interactions in host health and disease
4. Describe mechanisms of multidisciplinary dialogue between the microbiome, immune response, and neuronal system
5. Apply the acquired information to solve research questions/case studies attributed to the topic
6. Analyze microbiota composition data and demonstrate biological interpretation of results
7. Develop critical view on the role of microbiome in human health
8. Use the acquired knowledge to design experiments about the microbiome- host crosstalk.
Omschrijving The course addresses advanced concepts in interactions between humans and their gut microbes (microbiota).

The course aims to:
• Provide emphasis on the host-microbiota interaction with a focus on the link between the gut microbiota, nutrition, health and disease.
• Provide multidisciplinary guidance in microbiology, nutrition, microbiota signaling, immunity, and neuroendocrinology.

Education on different aspects of the interaction between the microbiota and nutrition in health and disease. This will discuss a- how the nutrient flow shapes the microbiota and its metabolic profile, which in turn, drive the cross talk between the gut microbes with the host immune, gut-brain axis, metabolic systems, b- how to develop microbiota-based therapy through the manipulation of the microbial community (e.g. fecal transplantation, probiotics and prebiotics).

Course content:
1. Introduction to microbiome; oral, skin, and gut (composition and function). (El Aidy)
2. Metagenomic (pathway analysis) and Multi-omics bio-bank cohort analysis (Harmsen)
3. Early live microbiome (Harmsen + El Aidy)
4. Diet and Lifestyle and microbiome (El Aidy)
5. Small intestinal bacteria (link to oral microbiota), Cross feeding among the gut microbes (Harmsen)
6. Host immunity and microbiome (innate and adaptive) (El Aidy)
7. Microbiome and gut disorders (IBD). (Harmsen)
8. Auto-immune diseases (T1-diabetes, Rheumatoid arthritis, Asthma, Multiple sclerosis) (Harmsen)
9. Microbiome and the Gut-Brain axis (El Aidy)
10. Microbiome and neurodegenerative disorders (El Aidy)
11. Microbiome interventions, FMT Pre and Probiotics (Harmsen)
Uren per week
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(LC-30 hrs, T-22 hrs: solving problems collaboratively; data analysis (incl. hours needed to complete the task), ASM: report, PRC-8hrs (incl. hours needed to complete the task), Self study-80 hrs)
Toetsvorm Meerkeuze toets (MC), Verslag (R)
(WE-44%, MC-36%, R-20%. The final score for the exam should be at least 5.0, which can be compensated with the practical report. The practical report should be handed in with a mark higher than 4.0. The final mark should be at least 5.5.)
Vaksoort bachelor
Co├Ârdinator S. El Aidy, PhD.
Docent(en) S. El Aidy, PhD. ,dr. ir. H.J.M. Harmsen
Verplichte literatuur
Titel Auteur ISBN Prijs
Biology of microorganisms
Michael T Madigan et al.
The Immune System
Peter Parham
Entreevoorwaarden Prior knowledge: Basic Cell & Molecular Biology, Physiology, Genetics, Ecology & Evolution, Microbiology, Biostatistics 1, Behavioural Neuroscience, Molecules of Life, Cell Biology & Immunology, Biochemistry & Cell Biology, Metabolism, Bioinformatics

Students from other degree programmes than Biology and/or Life Science & Technology who would like to participate in this course unit need to have basic knowledge on human (cell) biology, microbiology and molecular biology. Students are obliged to contact one of the academic advisors before enrolling in this course in order to check whether they have met de entrance requirements. After this contact, students also have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this entire procedure before the official enrollment deadline, results in immediate unenrollment without prior notification.

Students from the Bachelor's degree programmes Biology and Life Science & Technology take priority over students from other degree programmes when the course has a maximum capacity.
Opmerkingen This course has two coordinators:
S. El Aidy, PhD
Dr H.J.M. Harmsen

Tutorials are mandatory. In case of absence without prior permission and without a demonstrable valid reason, the practical cannot be completed.

Students who participated in an earlier edition of the course are exempted from the practical, if they previously obtained a sufficient grade for this course element; in such cases, the partial grade for the practical obtained earlier remains valid

The course prepares an understanding of the general concepts in Host- gut microbe interactions and provides skills usable for various majors (Biomedical Sciences, Behavior and Neurosciences). It is an elective course for students in Biology and Life Sciences and Technology. At the end of the course the students are expected to have an overview for the multidisciplinary interactions between the human being and its gut microbes.
Opgenomen in
Opleiding Jaar Periode Type
BSc Biology: major Biomedical Sciences 2 semester I b verplicht
BSc Biology: major Integrative Biology 2 semester I b keuzegroep
BSc Biology: major Molecular Life Sciences 2 semester I b verplicht