Molecular Genetics

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WBBY008-05
Vaknaam Molecular Genetics
Niveau(s) bachelor
Voertaal Engels
Periode semester I a
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Molecular Genetics
Leerdoelen At the end of the course, the student is able to:
1) explain the main concepts of molecular genetic mechanisms in prokaryotes and eukaryotes, such as DNA replication,
transcription, and their regulation
2) explain the basis of epigenetic regulation of transcription and its role in maintaining cell pluripotency and driving cell
differentiation
3) describe the genetic organization and life cycle of retroviruses, temperate and virulent bacteriophages, and the
resistance against the latter
4) explain the main DNA manipulation, genetic engineering and gene editing techniques
5) describe the main omics techniques, such as DNA-seq, RNA-seq and proteomics
6) relate experimental techniques to basic biological/biochemical phenomena, by linking and integrating different concepts
acquired during this course
Omschrijving This is a follow-up course of the first-year courses Basic Cell and Molecular Biology, and Genetics, Ecology and Evolution. It covers the main concepts of molecular genetic mechanisms in prokaryotic and eukaryotic organisms. Genome organization and integrity, DNA damage and repair, homologous- and site-specific recombination, gene regulation, plasmid biology, genomics and -omics techniques will be further deepened, while also the genetic organization and life cycle of retroviruses, temperate and virulent bacteriophages will be dealt with. Resistance mechanisms against bacteriophages and the subsequent development of genetic engineering and gene editing technology (CRISPR-Cas) will be exemplified. The importance of molecular genetics in developments in Biotechnology, System- and Synthetic Biology and the impact that molecular genetic techniques have in fundamental research, medicine, agriculture and society at large will be discussed.

Overall, the Molecular Genetics course unit will prepare students for (and will provide the necessary background knowledge to understand the topics treated in) the upcoming course unit(s) of the BScs Biology and Life Science & Technology, such as: Bioinformatics (semester Ia), Genes and Behaviour (semester Ib), Evolutionary Processes (semester IIa), Human Genetics and Genomics (semester IIa), Epigenetics and Gene-editing (semester IIa), Evolutionary Medicine (semester IIa), Practical Carrousel (semester IIa), Evolutionary and Ecological Genomics (semester IIb).
Uren per week
Onderwijsvorm Hoorcollege (LC)
(LC-30 hrs; self-study 110 hrs)
Toetsvorm Schriftelijk tentamen (WE)
(WE: 60% open questions, 40% multiple choice questions. Grade for the exam (OQ + MC) should be higher than 5,5)
Vaksoort bachelor
Coördinator D. Incarnato, PhD.
Docent(en) P. Alvarez Sieiro, PhD. , D. Incarnato, PhD.
Verplichte literatuur
Titel Auteur ISBN Prijs
Lewin's Essential GENES 4th 2020 Jocelyn E. Krebs, PhD; Elliott S. Goldstein, PhD; Stephen T. Kilpatrick,PhD 9781284173130
Entreevoorwaarden The course units assumes prior knowlegde and skills, acquired from the first-year courses Basic Cell and Molecular Biology; Genetics, Ecology and Evolution. In particular, basic knowledge of the structure of nucleic acids and proteins, as well as of the mechanism of action of key enzymes (polymerases, restriction endonucleases, etc.) is needed.

PLEASE NOTE
This course unit is only accessible to students enrolled in the Bachelor's programmes Biology or old curriculum Life Science & Technology. Students following other degree programmes cannot follow this course unit and will be unenrolled in Progress.
Opmerkingen
Opgenomen in
Opleiding Jaar Periode Type
BSc Biology: major Behaviour and Neurosciences 2 semester I a verplicht
BSc Biology: major Biomedical Sciences 2 semester I a verplicht
BSc Biology: major Integrative Biology 2 semester I a verplicht
BSc Biology: major Molecular Life Sciences 2 semester I a verplicht
Pre-master/Fast-track for MSc BCN - Biology - BMS - semester I a verplicht