Medical Structural Biology

Uitgebreide vaknaam	Medical Structural Biology
Leerdoelen	At the end of the course, the student is able to: 1. Describe the three-dimensional structure of macromolecules (i.e. proteins and nucleic acids) and explain the forces keeping these structures together; 2. Predict the general properties (and functions) of macromolecules based on their three-dimensional structure; 3. Explain the principles and limitations of fragment based design and virtual screening; 4. Calculate affinity and fraction of saturation for a given reaction and evaluate the strength of interactions; 5. Select the appropriate technique to study drug-protein interaction.
Omschrijving	In this course students will get an overview of techniques used for structural characterization and analysis of protein-drug interactions. This will be preceded with an overview of general principles of organization of proteins and nucleic acids. Topics will include structures of proteins (soluble and membrane-embedded) from the drug development point of view; basic principles of drug-protein interactions; biophysical methods to characterize drug-protein complex formation (X-ray crystallography, cryo-Electron Microscopy, Nuclear Magnetic Resonance), and an introduction into fragment based drug design and virtual screening.
Uren per week
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Werkcollege (T) (LC-20hrs; S-4 hrs; T-8hrs; Self-study-80 hrs)
Toetsvorm	Schriftelijk tentamen (WE) (WE-100%. The minimum pass grade is 5.5)
Vaksoort	bachelor
Coördinator	dr. A. Guskov
Docent(en)	C. Batista Paulino, PhD. , A.A. de Bruyn-Rybczynska, PhD. ,dr. A. Guskov ,dr. A.M.W.H. Thunnissen ,prof. dr. P.C.A. van der Wel
Verplichte literatuur	Titel Auteur ISBN Prijs The Molecules of Life John Kuriyan, Boyana Konforti, David Wemmer 9780815341888 €  60,00
Entreevoorwaarden	Basic knowledge of structures, chemical properties, and roles of the most important classes of biomolecules: DNA, RNA, and proteins acquired from ‘Molecules of Life’ and ‘Biochemistry’ courses. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Tutorials and a seminar are mandatory. The seminar is a mock examination. Tutorials are computer-based, where visualising the structures enables a deeper understanding of principles of structural organization of proteins and nucleic acids Not mandatory but recommended: "How Proteins work", Mike Williamson (2011). ISBN: 9780815344469 Dit vak had vorig jaar vakcode WBLS19005
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Biomedical Sciences 2 semester I a keuzegroep BSc Biology: major Molecular Life Sciences 2 semester I a keuzegroep BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester I a keuzegroep BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester I a keuzegroep