Medical Structural Biology

Uitgebreide vaknaam	Medical Structural Biology
Leerdoelen	At the end of the course, the student is able to: 1. Describe the three-dimensional structure of macromolecules (i.e. proteins and nucleic acids) and explain the forces keeping these structures together; 2. Predict the general properties (and functions) of macromolecules based on their three-dimensional structure; 3. Explain the principles and limitations of fragment based design and virtual screening; 4. Calculate affinity and fraction of saturation for a given reaction and evaluate the strength of interactions; 5. Select the appropriate technique to study drug-protein interaction.
Omschrijving	In this course students will get an overview of techniques used for structural characterization and analysis of protein-drug interactions. This will be preceded with an overview of general principles of structural organization of proteins and nucleic acids, as well as their interactions with ligands. Topics will include structures of soluble and membrane-embedded proteins; RNA and DNA; basic principles of drug-protein interactions; basic information about viruses and vaccine development; biophysical methods to characterize drug-protein complexes (X-ray crystallography, cryo-Electron Microscopy, Nuclear Magnetic Resonance), and an introduction into drug design.
Uren per week
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Werkcollege (T) (LC-20hrs; S-4 hrs; T-8hrs; Self-study-80 hrs)
Toetsvorm	Schriftelijk tentamen (WE) (WE-50%, MC-50%. The minimum pass grade is 5.5)
Vaksoort	bachelor
Coördinator	Prof. Dr. A. Guskov
Docent(en)	A.A. de Bruyn-Rybczynska, PhD. ,Prof. Dr. A. Guskov ,dr. A.M.W.H. Thunnissen
Verplichte literatuur	Titel Auteur ISBN Prijs The Molecules of Life, 2012 John Kuriyan, Boyana Konforti, David Wemmer 9780815341888 €  60,00
Entreevoorwaarden	Basic knowledge of structures, chemical properties, and roles of the most important classes of biomolecules: DNA, RNA, and proteins acquired from ‘Molecules of Life’ and ‘Biochemistry’ courses PLEASE NOTE Students from other degree programmes than Biology and/or Life Science & Technology who would like to participate in this course unit need to have basic knowledge on proteins and nucleic acids. Students are obliged to contact one of the academic advisors before enrolling in this course in order to check whether they have met de entrance requirements. After this contact, students also have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this entire procedure before the official enrollment deadline, results in immediate unenrollment without prior notification. Students from the Bachelor's degree programmes Biology and Life Science & Technology take priority over students from other degree programmes when the course has a maximum capacity.
Opmerkingen	Computer based tutorials are mandatory, the seminar is not mandatory. The seminar is a mock examination. The tutorials are designed to assist learning as visualising the structures enables a deeper understanding of principles of structural organization of proteins and nucleic acids and drug - protein (nucleic acids) interactions. Guest lecturers: Patrick van der Wel, Christina Batista Paulino
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Biomedical Sciences 2 semester I a keuzegroep BSc Biology: major Molecular Life Sciences 2 semester I a keuzegroep Pre-master/Fast-track for MSc BCN - Biology - BMS - semester I a verplicht