Genes and Evolution

Faculteit Science and Engineering
Jaar 2021/22
Vakcode WBBY004-05
Vaknaam Genes and Evolution
Niveau(s) bachelor
Voertaal Engels
Periode semester I a

Uitgebreide vaknaam Genes and Evolution
Leerdoelen At the end of the course, the student is able to:
1) define and quantify genetic variation and explain its relevance to evolution; calculate allele and genotype frequencies, Hardy-Weinberg proportions and simple extensions of these, and linkage equilibrium and explain their relevance
2) define and quantify genetic drift and discuss its consequences
3) analyse several scenarios of natural selection
4) calculate and interpret results from F-statistics as a measure of population differentiation and inbreeding
5) defend and argue how evolutionary mechanisms affect genetic variation and phenotypic evolution
6) describe phylogenetic processes and conduct and interpret advanced phylogenetic analyses
7) define concepts relevant to the relationship between gene trees and species trees, and the population genetic processes covered in this course unit
8) describe various mechanisms of molecular and genomic evolution and interpret simple examples of such mechanisms
Omschrijving The course unit will introduce students to population genetic processes in relation to evolution on the microscale. These principles
will be illustrated in computer practicals. Students will also be introduced to neutral and adaptive evolution, as well as molecular and genome evolution. Various advanced phylogenetic principles will be explained and illustrated in computer practicals.

The topics covered in this course unit are:
– population genetic processes (mutation, genetic drift, migration and selection, random mating, Hardy-Weinberg equilibrium, linkage, non-random mating, inbreeding)
– selection models (linear selection, overdominance, frequency-dependent selection, selection at various levels, complex selection)
– effects of population genetic processes on the dynamics of genetic variation
– fragmentation, gene flow/migration and genetic differentiation between populations (F-statistics)
– molecular and genomic evolution (intron-exon structure, gene duplication, concerted evolution, transposable elements)
– phylogenetic analysis (neutral theory, molecular clock, speciation)
– molecular techniques (microsatellite analysis, analysis of genetic data and structure, DNA sequencing, QTL analysis)
Uren per week
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(LC-27 hrs, T-16hrs, PRC-28hrs, self-study 69 hrs)
Toetsvorm Schriftelijk tentamen (WE)
(WE-100%. Grading is based on the results of the digital Exam. Practicals will be graded pass or fail. To pass this course a pass mark is needed for all the practicals, and a grade higher than 5.5 for the written exam. Open book exam.)
Vaksoort bachelor
Coördinator prof. dr. B. Wertheim
Docent(en) prof. dr. L.W. Beukeboom ,dr. E. Geuverink
Verplichte literatuur
Titel Auteur ISBN Prijs
Evolutionary Analysis, 5th edition, 2014 Herron & Freeman 1- 292- 06127 -8 €  70,00
Entreevoorwaarden Genetics, Ecology & Evolution

Students from other degree programmes than Biology and/or Life Science & Technology who would like to participate in this course unit need to have basic knowledge and understanding of evolution and genetics (as taught in the BSc course Genetics, Ecology and Evolution - WBBY005-05). Students are obliged to contact one of the academic advisors before enrolling in this course in order to check whether they have met de entrance requirements. After this contact, students also have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this entire procedure before the official enrollment deadline, results in immediate unenrollment without prior notification.

Students from the Bachelor's degree programmes Biology and Life Science & Technology take priority over students from other degree programmes when the course has a maximum capacity.
Opmerkingen All practicals (computer & wet-leb) are mandatory. There are no exemptions for students that do a re-sit for the course (i.e. that did not pass the written exam earlier): they need to re-do the practicals & assignments, also if these were passed in an earlier edition of the course. In case of illness or a fail to a practical part, there is an opportunity during the course for repair

Maximum capacity: 80 students

When we cannot do the experiment (wet-lab practical) due to Covid-19 restrictions, we will offer an online alternative, using experimental data from previous years.
Opgenomen in
Opleiding Jaar Periode Type
BSc Biology: major Behaviour and Neurosciences 2 semester I a keuzegroep
BSc Biology: major Ecology and Evolution 2 semester I a verplicht
BSc Biology: major Integrative Biology 2 semester I a keuzegroep
Pre-master/Fast-track for MSc BCN - Biology - BMS - semester I a verplicht