Interface Biology

Faculteit Science and Engineering
Jaar 2019/20
Vakcode MLBMTGB05
Vaknaam Interface Biology
Niveau(s) master
Voertaal Engels
Periode semester I a

Uitgebreide vaknaam Interface Biology
Leerdoelen At the end of this course you will have knowledge of and insight in biological processes that occur at material surfaces, related to the biomedical applications of these materials.

1) The student can describe, explain and apply the basic principles of cell signaling, including focal adhesions and their
function in cell-material interactions.
2) The student can describe, explain and apply the principles of blood coagulation and complement activation in relation
to material surfaces.
3) The student can formulate the phenomenon “conditioning film”, describe the buildup of proteins from primary to tertiary
structure, analyze the causative relations between material surface properties and conditioning film composition and
argue/reason how the conditioning film influences cell adhesion.
4) The student can apply knowledge of cell adhesion processes, material surface characteristics and conditioning film
properties on interpreting the results of scientific studies in the area of cell-material interactions, including the use of
smart biomaterials and nanometer range surfaces.
5) The student can critically assess scientific publications and can integrate information into a structured essay taking
into account the rules of scientific conduct of the RUG.
Omschrijving This course is devoted to the very diverse relations that exist between the living elements on one hand and the materials world on the other. Living elements include eukaryotic cells and micro-organisms, tissues, proteins and blood.
Many, if not all materials are sensed by the body as foreign. The body responds to the presence of the material. This can result in both desired and undesired effects. The course is fundamental in nature, but with clear references to the literature, clinical problems and trends within the use of materials for biomedical devices. The breadth of living elements necessitates a good knowledge of the essentials of cell biology, although care will be taken to explain the relevant concepts.

By the end of the module, students will have knowledge and an understanding of biological processes that occur on material surfaces, related to the biomedical applications of these materials.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM)
(The assignment in the course is an Essay assignment.)
Toetsvorm Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
(Students are assessed using a written end-term exam with open and essay questions (T(e)), and essay with a presentation component (P) and a written report component (R) on an assignment. The ratio for grading is End-term exam : Presentation: Written Report (T(e):P:R) = 6:2:2. Each grade has to be 4.5 or larger.)
Vaksoort master
Coördinator dr. T.G. van Kooten
Docent(en) dr. T.G. van Kooten
Verplichte literatuur
Titel Auteur ISBN Prijs
Study material is provided on nestor as lecture powerpoints and scientific
Biomaterials Science - An introduction to materials in medicine; Harcourt
Publishers Limited / Academic Press, 3rd edition, 3rd 2012
B.D. Ratner et al 9780123746269
Entreevoorwaarden The course unit does not assume prior knowledge.
Opmerkingen Study load:
Lecture: 20 hours
Assignment: 60 hours
Self-study: 60 hours
Total: 140 hours (= 5 ECTS)
Opgenomen in
Opleiding Jaar Periode Type
MSc Biomedical Engineering: Biomaterials Science and Engineering 1 semester I a verplicht
MSc Biomedical Engineering: Medical Device Design 2 semester I a verplicht
MSc Courses for Exchange Students: Biology & Life Sciences - semester I a verplicht