Stem Cell and Glia Biology

Faculteit Science and Engineering
Jaar 2017/18
Vakcode MLBCNN04
Vaknaam Stem Cell and Glia Biology
Niveau(s) master
Voertaal Engels
Periode semester I

Uitgebreide vaknaam Stem Cell and Glia Biology
Leerdoelen The brain is composed of neurons and non-neuronal cells. In the past two
decades, it became increasingly evident that non-neuronal cells are vital for the brain development and function.
The general objective of this course is making students familiar with the cell biology of non-neuronal cells in the central neuronal system (CNS), including their ontogeny, physiology, and pathophysiology.
At the end of the course, students should be able to:
- explain the major aspects of stem cells and neurodevelopment, the physiology and pathophysiology of the various types of non-neuronal CNS cells, glia signaling and neuroimmunology.
- critically evaluate, summarize and present research reported in a relevant scientific publication.
- to understand and apply basic procedures of cell imaging using standard fluorescence microscopy and (advanced) confocal laser microscopy for the analysis of CNS cell- and tissue samples
Omschrijving The course presents an overview of the development, physiology and
function of all non-neuronal cell types within the mammalian central nervous system (CNS). The course addresses the ontogeny and function of different non-neuronal cell types present in the CNS, like astrocytes, oligodendrocytes, microglia, neural stem cells, and cells contributing to the blood-brain- barrier. In addition, the role of these cells in pathogenic processes (e.g. in neurodegenerative diseases) in the CNS will be addressed. Most of the lectures will be presented by internal or external guest lecturers that are considered renowned experts in the specific relevant areas. Apart from following the lectures and studying relevant supportive literature, students will present a presentation about a subject related to one of the lectures based on recent papers in high-impact scientific journals.
The course will end with a microscopy practicum, in which the students will become familiar with state-of- the–art (immunofluorescent) cellular imaging techniques (e.g. confocal laser microscopy), standardly used in research on molecular and cellular aspects of the CNS.
Uren per week variabel
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(Practicum cellular imaging techniques. Mandatory attendance.)
Toetsvorm Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
(2x written exam: 35 % exam Stem cells; 35% exam Glial cells; 10% literature presentation; 20% essay Practicum cellular imaging techniques)
Vaksoort master
Coördinator prof. dr. A. Kocer
Docent(en) dr. W. Baron ,prof. dr. K.P.H. Biber ,prof. dr. B.J.L. Eggen , Gastdocent(en) ,prof. dr. A. Kocer ,prof. dr. F.A.E. Kruyt ,prof. dr. J.D. Laman ,dr. J.T.M.L. Paridaen ,prof. dr. L.A. 't Hart
Entreevoorwaarden Minimum: 5 students
This course is available for BCN research master students only.
Opmerkingen 28 hrs lectures
10 hrs werkcollege
10 hrs practicum
Opgenomen in
Opleiding Jaar Periode Type
MSc Behavioural and Cognitive Neurosciences; Research master  (BCN N track) 1 semester I b mandatory N-track