Stem Cell and Glia Biology

Faculteit Science and Engineering
Jaar 2018/19
Vakcode MLBCNN04
Vaknaam Stem Cell and Glia Biology
Niveau(s) master
Voertaal Engels
Periode semester I
ECTS 5
Rooster rooster.rug.nl

Uitgebreide vaknaam Stem Cell and Glia Biology
Leerdoelen At the end of the course, the student is able to:
1) describe, and explain the major aspects of stem cells and neurodevelopment, the physiology and pathophysiology of the various types of non-neuronal CNS cells, glia signaling and neuroimmunology.
2) critically evaluate, summarize and present research reported in a relevant scientific publication
3) to understand and apply basic procedures of cell imaging using standard fluorescence microscopy and (advanced) confocal laser microscopy for the analysis of CNS cell- and tissue samples.
Omschrijving The general objective of this course is making students familiar with the cell biology of non-neuronal cell types in the central nervous system (CNS), including their ontogeny, physiology, and pathophysiology.

1. The students should be able to describe and explain the major aspects of stem cells and neurodevelopment, the physiology and pathophysiology of the various types of non-neuronal CNS cells.
2. The students should be able to critically evaluate, summarize and present research reported in a relevant scientific publication.
3. The students should be able to understand and apply basic procedures of cell imaging using standard fluorescence microscopy and (advanced) confocal laser microscopy for the analysis of CNS cell- and tissue samples.
Specific Objectives: (1) Overviewing glia biology and associated neurodegenerative diseases, (2) Overviewing stem cell technology and applications, (3) Gaining practical knowledge in cellular imaging technology (4) Reading, presenting, and peer reviewing of scientific literature.

CONTENT:
Block 1: Glia cell biology
Here students will receive lectures addressing the physiological and pathophysiological properties of the various types of glia. The topics will be on
• Glia (general introduction)
• Microglia
• Astrocyte biology
• Oligodendrocyte biology
• Adaptive immunity in the CNS
• Bacterial inflammation and neuroglia
• Student presentation and peer review on glia

Block 2: Stem cell biology
This block consists of a lecture series addressing the biology and possible future therapeutic applications of neural stem cells, including the following lecturing topics:
• Neural stem cells
• Glioblastoma stem cells
• The blood-brain barrier
• iPSC technology
• Student presentation peer review on stem cells
Practicum: Cellular imaging (M. Meier: dept. Neuroscience):
Students will attend a short course in (fluorescence) microscopy. The goal is to obtain practical knowledge on the use of confocal laser-microscopy.
Uren per week variabel
Onderwijsvorm Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
(Practicum cellular imaging techniques. Mandatory attendance.)
Toetsvorm Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
(2x written exam: 35 % exam Stem cells; 35% exam Glial cells; 10% literature presentation; 20% essay Practicum cellular imaging techniques)
Vaksoort master
Co├Ârdinator prof. dr. A. Kocer
Docent(en) dr. W. Baron ,prof. dr. K.P.H. Biber ,prof. dr. B.J.L. Eggen , Gastdocent(en) ,prof. dr. A. Kocer ,prof. dr. F.A.E. Kruyt ,prof. dr. J.D. Laman ,dr. J.T.M.L. Paridaen ,prof. dr. L.A. 't Hart
Entreevoorwaarden Minimum: 5 students
This course is available for BCN research master students only.
Opmerkingen 28 hrs lectures
10 hrs werkcollege
10 hrs practicum
Opgenomen in
Opleiding Jaar Periode Type
MSc Behavioural and Cognitive Neurosciences; Research master  (BCN N track) 1 semester I b mandatory N-track