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Stereochemistry
| Faculteit | Science and Engineering |
| Jaar | 2020/21 |
| Vakcode | WMCH013-05 |
| Vaknaam | Stereochemistry |
| Niveau(s) | master |
| Voertaal | Engels |
| Periode | semester I b |
| ECTS | 5 |
| Rooster | rooster.rug.nl |
| Uitgebreide vaknaam | Stereochemistry | ||||||||||||||||||||||||||||||||
| Leerdoelen | At the end of the course, the student is able to: 1.Identify different types of chirality (e.g. point, axial, helical and planar chirality) and stereoisomerism (e.g. enantiomers, diastereomers, conformers, atropisomers). 2.Apply CIP sequence rules and Fischer projections to give the correct stereochemical assignment for chiral molecular structures. 3.Explain which is the most stable conformation of certain alkanes, cycloalkanes and biaryl compounds (using Newman projections, among others). 4.Use CD and ORD spectra to determine absolute configuration, conformation and enantiopurity of chiral molecules. 5.Predict the stereochemical outcome of stereospecific and stereoselective chemical reactions. 6.Design a stereoselective synthesis route for a given chiral molecule. 7. Critically evaluate a recent research article related to a topic in stereochemistry. |
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| Omschrijving | This course gives an in-depth treatment of stereochemistry. First, different types of chirality and the rules for chirality assignment are explained. Then, conformational isomerism is discussed in detail which is followed by an introduction to basic rules and theories to determine absolute configuration, conformation, and enantiopurity using CD and ORD. Finally, a thorough understanding of stereoselective synthetic methods is provided. The course is concluded by an overview of chiral resolution methods and a discussion on the origin of homochirality on earth. Specific topics to be treated include: Absolute and relative configuration, stereospecific and stereoselective reactions, circular birefringence and dichroism, supramolecular chirality, asymmetric synthesis and catalysis. | ||||||||||||||||||||||||||||||||
| Uren per week | |||||||||||||||||||||||||||||||||
| Onderwijsvorm |
Hoorcollege (LC)
(Lectures: 20 hours, Self study: 120 hours.) |
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| Toetsvorm |
Schriftelijk tentamen (WE), Verslag (R)
(Final mark: Written exam (80%), Report (20%). See remarks.) |
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| Vaksoort | master | ||||||||||||||||||||||||||||||||
| Coördinator | prof. dr. T. Kudernác | ||||||||||||||||||||||||||||||||
| Docent(en) | prof. dr. B.L. Feringa | ||||||||||||||||||||||||||||||||
| Verplichte literatuur |
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| Entreevoorwaarden | The course unit assumes prior knowledge acquired from Organic Chemistry 1 and 2 (BSc Chemistry) or equivalent and Structure Determination with Spectroscopic Methods (MSc Chemistry). | ||||||||||||||||||||||||||||||||
| Opmerkingen | Final mark = 0.8 x mark for exam + 0.2 x mark for report; rounded off to nearest 0.5 mark (except between 5 and 6, where rounding takes place to the nearest integer mark); Pass mark = 6. This course was registered last year with course code CHOSC05E |
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| Opgenomen in |
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