Ocasys: Ocasys: Online Onderwijscatalogus

Rijksuniversiteit Groningen

Hieronder staan het programma en de vakomschrijvingen van BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) Klik op de naam van een vak in een schema om naar de omschrijving te gaan.

Periode	Type	Code	Naam	Taal	ECTS	Uren
» Jaar 2
semester I a	verplicht	WBBY002-05	Bioinformatics	Engels	5
	verplicht	WBBY008-05	Molecular Genetics	Engels	5
	keuzegroep A	WBBY006-05	Integrative Neuroscience	Engels	5
	keuzegroep A	WBBY007-05	Medical Structural Biology	Engels	5
semester I b	verplicht	WBBY019-05	Host-microbe Interactions	Engels	5
	verplicht	WBBY020-05	Immunology	Engels	5
	verplicht	WBBY024-05	Modelling Life	Engels	5
semester II a	verplicht	WBBY034-05	Cell Biology and Microscopy	Engels	5
	verplicht	WBBY072-05	Cell Migration and Communication	Engels	5
	verplicht	WBBY048-05	Practical Carrousel	Engels	5
semester II b	verplicht	WBBY049-05	Biology & Society: Ethical and Professional Aspects	Engels	5
	verplicht	WBBY050-05	Bio-organic Chemistry	Engels	5
	verplicht	WBBY053-05	Enzymology and Thermodynamics	Engels	5

Opmerkingen	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
» Jaar 3
Periode	Type	Code	Naam	Taal	ECTS	Uren
semester I b	keuze*	WBBY023-05	Minor congress (Life Sciences)	Engels	5
semester II a	verplicht	WBBY048-05	Practical Carrousel	Engels	5
	keuzegroep B	WBBY073-05	Bioanalytical and Omics Techniques	Engels	5
	keuzegroep B	WBBY074-05	Biotechnology	Engels	5
	keuze	WBBY030-05	Biology of Cancer	Engels	5
	keuze	WBBY039-05	Evolutionary Medicine	Engels	5
	keuze	WBBY041-05	Food and Metabolism	Engels	5
	keuze	WBBY042-05	Human Genetics and Genomics	Engels	5
	keuze	WBBY043-05	Immunology and Disease	Engels	5
	keuze	WBBY045-05	Medical Cell Biology	Engels	5
semester II b	verplicht	WBBY901-05	Bachelor's Thesis Life Sciences	Engels	5
	verplicht	WBBY904-10	Research Project Molecular Life Sciences	Engels	10
	keuzegroep B	WBBE022-05	Programming for Life Sciences	Engels	5
	keuze	WBBY051-05	Cardiovascular Disease	Engels	5
	keuze	WBBY061-05	Molecular Research in Human Disease	Engels	5
	keuze	WBBY062-05	Neurobiology of Ageing	Engels	5

Opmerkingen	Two of the course units of option group B are compulsory for the major programme Molecular Life Sciences (10 ECTS in total). For more information, please check the Student Portal. The course "Minor congress" (WBBY023-05) is compulsory for students who are following a minor programme in the life sciences. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.

Toon korte vakomschrijvingen

Bachelor's Thesis Life Sciences

WBBY901-05

The Bachelor’s thesis, combined with the Bachelor’s research project, forms the last phase of your Bachelor’s degree programme. By writing a Bachelor’s thesis, students demonstrate that they are able to conduct literature research at an academic Bachelor’s level and document the results in a report. Students are expected to complete this task largely independently, supported by the advice of a supervisor.

The Bachelor’s thesis involves carrying out a literature search based on a problem statement, an objective and research questions. The aim of the thesis is to allow students to show that they are capable of recruiting insights from the literature to construct a substantiated, individual opinion on an unresolved problem, and are able to present this opinion in a logical, well-argued written report.

Writing and formulation skills are therefore taken into account when assessing the thesis. Making a work plan and implementing it within the given period are also a constituent part of the assessment of the Bachelor’s thesis. The scientific focus of the Bachelor’s thesis lies within the research field of the student’s Major, and is connected to (one of) his or her Bachelor’s research project(s).

Note that it is intended as a work focusing on the established literature in the research field, not as a vehicle for further processing the results of the Bachelor’s research project. Based on the findings from the literature, the student must construct a substantiated individual opinion and be able to present this opinion in a logical, well-argued written report.

Supervised by a lecturer, the student must:
1. formulate a research question in an academic manner
2. conduct a literature search
3. present the findings and conclusions in the form of an academic text (size of thesis: 10-15 pages, 4,500–6,500 words)
5. form a substantiated opinion or vision, which they are able to defend.

Faculteit	Science and Engineering
Voertaal	Engels
Docent(en)
Toetsvorm	Verslag (R)
ECTS	5
Entreevoorwaarden	A minimum of 120 ECTS credit points must have been earned in the Bachelor’s programme, including the propaedeutic phase. The subject of the Bachelor's thesis must fit in with the academic field of the Bachelor’s research project. The Bachelor’s thesis must normally be started after the Bachelor's research project has been completed.
Opmerkingen	• The thesis will be supervised by an examiner involved in the core teaching of the Major/degree programme concerned (see Student Portal) • Total student workload 140 hours (5 ECTS) More information on the Student Portal. Dit vak had vorig jaar vakcode WLS13

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Bioanalytical and Omics Techniques

WBBY073-05

This course aims to provide students with a better understanding of the main principles and applications of various bio-analytical and omics techniques in life science research.

Subjects covered in the course include:

- General principles of genomics, transcriptomics, proteomics and metabolomics
- DNA-protein interactions: EMSA, DNAse footprinting, Chip-seq, yeast2hybrid
- Protein-protein interactions: FRET, complex pull down, cross-linking, cryo-EM
- Secretome, subcellular protein localization, Pr-GFP studies, phenotypic heterogeneity
- Separation techniques: chromatography (affinity, ion-exchange, size exclusion, HPLC), electrophoresis
- Mass spectrometry: MALDI, ESI, MS-MS
- Spectroscopy: CD, UV, infra-red, fluorescence spectroscopy

Subjects will be explained in a number of lectures and seminars, augmented by computer tutorials.
In addition, students will receive group assignments to study from selected scientific publications a specific set of techniques in more detail (find out why and how they are applied, how data are analyzed, what are the advantages and limitations) and give a presentation on their findings.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. A.M.W.H. Thunnissen
Docent(en)	prof. dr. O.P. Kuipers dr. H.P. Permentier dr. A.M.W.H. Thunnissen
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	All classes, including seminars, tutorials and student presentations, are mandatory. If a class cannot be attended, the student needs to notify teacher or course coordinator stating the reason of absence. Unexcused absences may result in exclusion from the exam. Missed assignments will have to be carried out at a later time.

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Bioinformatics

WBBY002-05

This course presents an introduction to bioinformatics, to bioinformatics tools and databases. The databases used in the course are those in which genomes, genes, mRNAs, proteins, protein patterns, gene variants and gene/protein expression are stored. The bioinformatics tools will be used to perform sequence alignments, create phylogenetic trees, predict genes/exons/introns, meta-genomics, and to model biological processes on the basis of -omics datasets. Furthermore, databases will be used to study genetic variation and complex diseases.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. J. Kok
Docent(en)	dr. A. de Jong prof. dr. M. Heinemann D. Incarnato, PhD.prof. dr. J. Kok dr. A.M.W.H. Thunnissen
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Practisch werk (PR)
ECTS	5
Entreevoorwaarden	Basic genetics and statistics knowledge, as acquired in the first year of the BSc Biology and LST, is expected. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	All course elements are mandatory; No more than 10% missing out will be allowed but should be repaired, preferably during the course.

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Biology & Society: Ethical and Professional Aspects

WBBY049-05

The course allows the students to develop a critical, responsible and professional attitude towards their own role as a scientist and the consequences of their actions in a broader societal context. Students will be engaged into thinking about scientific and innovative practices that can address the global challenges of our time in a collaborative, ethical and sustainable way. To understand the relations between biology and society a number of basic elements from ethics, philosophy of science, innovation and policy making will be introduced. Students will practice applying these elements in (the assessment of) debates, controversies and cases related to the large societal challenges of our time, including themes such as responsible research and innovation, sustainability, and the role of science, business and policy in this. To demonstrate these aspects, an excursion to a company or policy organization is also part of this course.
This course is examined with an exam (multiple choice questions and essay question(s)) and a paper that students write in groups of four students. In this paper students need to apply the content of the course to a specific topic at the interface of biology and society.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	J. Zevenberg
Docent(en)	drs. S. Grooters dr. H.A.J. Mulder dr. B. Piersma M.J. van den Nieuwenhof-Schilstra, MSc.dr. H.J. van der Windt J. Zevenberg
Onderwijsvorm	Opdracht (ASM), Werkcollege (T), Bijeenkomst (S), Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Presentatie (P), Schriftelijk tentamen (WE), Verslag (R)
ECTS	5
Entreevoorwaarden	The course assumes no specific prior knowledge. This course is not allowed in the same bachelor study program as "Medical Technology & Society" (WLB07054/WBBE022-05) due to overlap. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The grade of the exam should be at least 5.0 and the grade of the paper should be at least 6.0. The final grade of the course should be at least 5.5 and will be completed according to the rules of the faculty. No grade is given when the student did not pass the mandatory presence and/or did not sufficiently made the replacement assingments(s) for the missed parts. The excursion, tutorials and the appointments with the TA are mandatory. In case of missing out of them without sufficient reason, a replacement assignment has to be made. Dit vak had vorig jaar vakcode WBLS19033

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Biology of Cancer

WBBY030-05

During this course we will discuss in the lectures: carcinogenesis, cancer stem cells, the role of oncogenes and tumor suppressor
genes, the large variety of subtypes within hematological and solid tumors, the signaling pathways active in different tumor types,
genetic regulation of these molecular pathways (epigenetics, miRNA), DNA damage response, the tumormicroenvironment , the
process of metastasis, tumor immunology, therapeutic strategies to inhibit tumor growth, development of cancer drugs,
development of clinically relevant cancer models, and clinical cancer research.
Each group of 4-5 students will investigate an interesting oncogene or tumor suppressor gene using publicly available databases.
Normal function of the gene of interest, its role in cancer, in which cancer type the gene plays a role, which mutations are found in
this cancer gene and how we can use this knowledge for treatment strategies. Results are presented during a poster session.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. S. de Jong
Docent(en)	dr. M. de Bruyn dr. R.S.N. Fehrmann prof. dr. F.A.E. Kruyt Other lecturers prof. dr. K. Poelstra prof. dr. J.J. Schuringa dr. G.B.A. Schuurs-Wisman prof. dr. M.A.T.M. van Vugt
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Meerkeuze toets (MC), Presentatie (P)
ECTS	5
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : Basic Cell and Molecular Biology PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Other lecturers: Prof. Anke van den Berg. First lecture and introduction poster activity are mandatory. Students have to report and explain their absence, otherwise they are not being registered as participant. This will allow other students to gain access to the course. Poster presentation is mandatory. Absence without notificating: no mark. With notification, they have to present the poster at another time. Capacity max: 100 Dit vak had vorig jaar vakcode WBLS19017

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Bio-organic Chemistry

WBBY050-05

The aim of this course is to gain insight in a number of important reactivity principles in Bio-organic Chemistry. A focal point is the understanding and the application of several reaction types that form the basis of cell metabolism, and to get insight in the structure and reactivity of molecules. Function and reactivity of molecules is discussed in the context of the living cell.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. ir. A.J. Minnaard
Docent(en)	prof. dr. ir. A.J. Minnaard N.R.M. Reintjens, MSc.
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Prior knowledge: Molecules of Life. It is not permitted to take this course unit together with Organic and Biosynthesis (Pharmacy) in a single Bachelor’s programme because of too much overlap in the curriculum. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The final mark is the mark of the exam. It is estimated that 50% of the exam is testing whether the student can reproduce the content of the course, 40% whether the student can apply the content (solving problems), and 10% whether the student has deeper insight and abstraction. Dit vak had vorig jaar vakcode WBLS19034

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Biotechnology

WBBY074-05

In this course, the student will learn the molecular basis of biotechnological tools and processes that are being developed and used

in research and industrial applications.
The course is designed for 3rd year bachelor Biology and/or Life Science & Technology students and is based on an integrated
approach, with several practical examples illustrating the whole process of development from an idea to a biotechnological process
or product.
The course focuses on biotechnology in the Materials, Food and Pharma biotech industry areas (total of 28 lectures). Except for
lectures on biotechnological tools and approaches in resaearch, there will be a number of lectures on application aspects, partially
by lecturers from companies. In addition, by visiting two biotechnology-oriented companies, a better view on research and
development in the biotechnological industry will be obtained. The students will also learn how intellectual property (IP) can be
protected by patent applications and other measures.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. ir. M.W. Fraaije
Docent(en)	prof. dr. R.A.L. Bovenberg S. El Aidy, PhD.prof. dr. J.T.M. Elzenga prof. dr. ir. M.W. Fraaije prof. dr. O.P. Kuipers prof. dr. G.N. Moll prof. dr. G. van den Bogaart
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The students must have completed the courses Molecules of Life or Biochemistry and Cell Biology in Ecology and Evolution. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Presence is mandatory for the lecture on IP and at the excursions to the biotech companies. The attendance will be monitored. No attendance has as consequence that the student is not allowed to do the exam. The course prepares for the Master Biomolecular Sciences. Max. capacity: 60 students.

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Cardiovascular Disease

WBBY051-05

During the course, students are introduced to the key mechanisms in the development of the heart and blood vessels as well as
basic knowledge on the development of major cardiovascular diseases, e.g. cardiac failure, atherosclerosis, sepsis, and vasculitis. In

addition, students will be informed on the basics of (therapeutic) regeneration in the cardiovascular system by stem cells or cell-
specific therapy.

The course schedule holds lectures in the morning (9.00 – 12.00h) and room for assignments or self-study (both 2-3 days/week) in
the afternoon. The assignments consist of research proposals on a cardiovascular disease and the design of a new therapeutic
approach. Assignments are supervised by experts in the field.
In the first week of the course, the development of heart and blood vessels is discussed. Lecture themes are as follows:
Development of the vascular System,
Functioning of the vascular system,
Development and functioning of the heart, and
Regeneration in the cardiovascular system.

In the second week of the course, the development and treatment of major cardiovascular diseases are discussed. Lecture themes
are as follows:
Inflammation in the vasculature: Vasculitis,
Diseases of the heart: Acute Myocardial Infarction and Cardiac Failure,
Diseases of the blood vessels: Atherosclerosis and vessel remodeling, and
Septic shock and multi-organ failure.
In the third week, the assignments are submitted and a digital exam will be taken.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. G. Krenning
Docent(en)	dr. J.H. Buikema dr. M.M. Faas Guest lecturer prof. dr. M.C. Harmsen prof. dr. P. Heeringa prof. dr. J.L. Hillebrands dr. J.A.A.M. Kamps dr. G. Krenning J. Moser dr. A. Rutgers dr. H.H.W. Sillje dr. M. van Meurs
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Presentatie (P), Tussentoets (IT)
ECTS	5
Entreevoorwaarden	Prior knowledge: Cell biology, anatomy and immunology from the 1st year Biology and LS&T programmes. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Presence during (parts of) the course is mandatory For the assignments, there are four (4) mandatory feedback sessions with experts in the field. Missing out of mandatory sessions (without proper cause) will result in a failing mark on the assignment. Capacity max: 60 students Dit vak had vorig jaar vakcode WBLS19035

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Cell Biology and Microscopy

WBBY034-05

Various microscopy approaches used in current molecular cell biology research will be discussed. A thorough understanding of molecular cell biology research will be obtained, focusing on mitochondria and the secretory pathway. Examples of molecular cell biology research will be discussed from a molecular to cellular level using in vitro and in vivo approaches in yeast and mammalian model systems.

Microscopy:
The students will be introduced to modern microscopy techniques used in the molecular life sciences (from the protein to cellular level). Topics include electron and fluorescence microscopy of cells/tissues, the use of fluorescent dyes and proteins, special fluorescence approaches such as FRAP (fluorescence recovery after photobleaching), FCS (fluorescence correlation spectroscopy) and FRET (Förster resonance energy transfer), superresolution microscopy, atomic force microscopy and optical tweezers.

Mitochondria:
An overview will be provided of the molecular mechanisms involved in mitochondrial biogenesis and dynamics (more specifically: protein translocation, fission (Dynamin related proteins) and fusion, inheritance and transport, contact sites). The biochemical, genetic and microscopy approaches used to study mitochondria will be discussed.

Protein secretion:
Intracellular membrane trafficking will be discussed, including ER-Golgi transport, exocytosis, endocytosis and lysosomal trafficking. The students will be introduced to the key mechanisms of intracellular cargo sorting, the formation of trafficking vesicles, the docking and fusion to target organelles and the molecular determinants of organellar identity.

ESCRT System and extracellular vesicles:
Many cellular processes such as endosomal vesicle budding, virus budding, and cytokinesis require extensive membrane remodeling by the endosomal sorting complex required for transport (ESCRT), of which a mechanistic view will be presented in this course. In addition an overview on extracellular vesicles, which are for instance involved in cell-to-cell communication and disease, will be discussed from a structure/function point of view.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. I.J. van der Klei
Docent(en)	prof. dr. W.H. Roos prof. dr. G. van den Bogaart prof. dr. I.J. van der Klei
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	This course builds on the first year courses “Basic Cell and Molecular Biology” and “Cell biology and Immunology”. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	For reference, parts of chapters 9 (Microscopy), 12 (Protein transport), 13 (Intracellular membrane transport) and 14 (Mitochondria and Chloroplasts) from the book Molecular Biology of the Cell will be used. Dit vak had vorig jaar vakcode WBLS19020

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Cell Migration and Communication

WBBY072-05

The aim of this course is to integrate knowledge from previous courses in order to achieve a more thorough molecular understanding of complex biological systems and behaviour.
Signal transduction in membranes:
Deepen the understanding of the concepts of channels and the electrical properties of membranes. An overview will be provided of the different gating mechanisms of channel proteins, the electrophysiology methods to probe the activity of channel proteins, the structural basis for the ion selectivity of channel proteins and the role of ion channels in the propagation of nerve impulses in neurons. The lectures also provide an overview of the structure and dynamics of biological membranes, and the mechanisms of solute and ion transport in generating electrochemical gradients.
Receptors and Signal transduction:
How can cells sense their environment and process incoming signals precisely. An overview will be provided of receptor classes and concepts of signal transduction and integration. Major classes of transmembrane and nuclear receptors in eukaryotes and bacteria will be discussed. Molecular concepts of downstream signaling in time and space, signal amplification, signal specificity and signal adaptation will be discussed. Molecular details of smell and vision (eukaryotic systems) as well as sensing of chemical gradients (chemotaxis in bacteria) will be discussed.
The cytoskeleton and extracellular matrix:
The composition, assembly and dynamics of cytoskeleton,as well as the function and regulation of actin, microtubules and intermediate filaments in cell organization, polarization and migration will be discussed. The main groups of cell-cell adhesion complexes will be discussed with a focus on epithelial cells. An overview of the main families of extracellular matrix will be provided,
and their roles in cell behavior and tissue organization will be addressed. The protein complexes that mediate cell adhesion to extracellular matrix will be discussed.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. M.H.K. Linskens
Docent(en)	S.K. Billerbeck, PhD.prof. dr. B. Poolman prof. dr. G. van den Bogaart
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.

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Enzymology and Thermodynamics

WBBY053-05

The course unit consists of the components thermodynamics and reaction kinetics. Both parts are based on the basic concepts of physical chemistry, which are then developed within the context of biological systems.
Thermodynamics starts by studying the overall picture of internal energy and the first law of thermodynamics, based on forms of energy, work and heat. Chemical reactions and thermodynamic techniques (e.g. the standard state) are introduced by means of enthalpy. The second law of thermodynamics as well as entropy and free energy are studied by looking at processes in biological systems.
The reaction kinetics component first considers basic concepts such as reaction speed, rate law, rate constant, rate equation and transition state. The concept of catalysis is then used to define the rate equation of an enzyme-catalysed reaction.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. D.J. Slotboom
Docent(en)	prof. dr. G. Maglia, PhD.prof. dr. D.J. Slotboom
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : Molecules of life, Metabolism, Basic cell and molecular biology, Biostatistics 1 PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The course unit prepares for and provides skills usable in the course unit(s) or degree programme(s): BSc research project in Biochemistry/Enzymology, MSc programs in Molecular Biology and Chemical Biology Dit vak had vorig jaar vakcode WBLS19036

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Evolutionary Medicine

WBBY039-05

We normally think of evolution as optimizing the phenotype of an animal so that it is well-adapted to its environment. So, the
existence of diseases such as influenza, cancer or HIV are a puzzle. The course will investigate why and how diseases which are
obviously harmful persist over evolutionary timescales?
This course will give a broad overview where ecological and evolutionary thinking can advance the understanding of human health
and disease. We will cover a range of topics including:

- A review of evolutionary genetics and dynamics
- The co-evolution of parasites and hosts
- Evolution of the immune system
- Evolution and origin of human infectious diseases
- Evolution of virulence – why are some infectious diseases fatal and others so mild that they are barely noticed?
- Evolution of sexually transmitted diseases
- The evolution of antibacterial and antimicrobial resistance
- Microbiota and human health
- Evolutionary processes operating in during cancer development
- The evolution of aging and diseases of old age
- The evolution of human reproductive disorders and pregnancy complications
- Applied evolution

The course is suitable for any student interested in evolution and ecology or a biomedical field.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. ir. M.G.J. de Vos
Docent(en)	dr. ir. M.G.J. de Vos M.G. Elliot, PhD.
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The Evolutionary Medicine course is part of the “Ecology and Evolution” and “Integrative Biology” specializations. As such it builds upon basic foundations of evolutionary biology acquired in the first year of the Biology curriculum. Students should have studied a first year course in evolution or a biomedical field. The course will be closely integrated with the following course units: Evolutionary Processes; Evolution and Development; Genes and Behaviour; Microbiome. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Tutorials, and poster presentation are mandatory. Missing a tutorial without good reason will result in a 10% downgrade. Dit vak had vorig jaar vakcode WBLS19024

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Food and Metabolism

WBBY041-05

A well balanced diet promotes the functioning of the body and prevents diseases. But what is a healthy diet and what is the
connection between nutrition and metabolism? How can disturbances in energy metabolism contribute to the development of chronic
diseases? These are the central questions in the course Food and Metabolism. During the course, you will learn the role of nutrition
and metabolism in the development of chronic diseases such as diabetes and cardiovascular disease. In the lectures, we will address
the structure, function and metabolism of macronutrients. In addition, you will gain more insight into the regulation of metabolism. In
the work lectures, you will gain a deeper insight into how specific nutrients and/or disturbances in energy metabolism contribute to
the pathogenesis of chronic diseases. Under the supervision of an expert, you will perform a literature study in the area of food and
metabolic diseases. The results of the literature study will be presented by a presentation and in the form of a scientific literature
review.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. J.K. Kruit
Docent(en)	dr. ir. E. Corpeleijn dr. ir. H.J.M. Harmsen prof. dr. J.W. Jonker dr. J.K. Kruit prof. dr. J.A. Kuivenhoven prof. dr. T. Plosch
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Presentatie (P), Verslag (R)
ECTS	5
Entreevoorwaarden	Students should have knowledge regarding the following: - Basic principles of cellular metabolism - Basic knowledge of the main biochemical pathways in primary carbon and energy metabolism PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Other (guest) lecturers: E. van de Beek Capacity max: 120 students. Attendance at the first lecture, working lectures and during presentation is mandatory. Mandatory parts: exam, report, working lecture, presentation, food diary assignment. If the student would miss a work lecture, the student will need to make a substitute assignment. Dit vak had vorig jaar vakcode WBLS19026

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Host-microbe Interactions

WBBY019-05

The course addresses advanced concepts in interactions between humans and their gut microbes (microbiota).

The course aims to:
• Provide emphasis on the host-microbiota interaction with a focus on the link between the gut microbiota, nutrition, health and disease.
• Provide multidisciplinary guidance in microbiology, nutrition, microbiota signaling, immunity, and neuroendocrinology.

Targets:
Education on different aspects of the interaction between the microbiota and nutrition in health and disease. This will discuss a- how the nutrient flow shapes the microbiota and its metabolic profile, which in turn, drive the cross talk between the gut microbes with the host immune, gut-brain axis, metabolic systems, b- how to develop microbiota-based therapy through the manipulation of the microbial community (e.g. fecal transplantation, probiotics and prebiotics).

Course content:
1. Introduction to microbiome; oral, skin, and gut (composition and function). (El Aidy)
2. Metagenomic (pathway analysis) and Multi-omics bio-bank cohort analysis (Harmsen)
3. Early live microbiome (Harmsen + El Aidy)
4. Diet and Lifestyle and microbiome (El Aidy)
5. Small intestinal bacteria (link to oral microbiota), Cross feeding among the gut microbes (Harmsen)
6. Host immunity and microbiome (innate and adaptive) (El Aidy)
7. Microbiome and gut disorders (IBD). (Harmsen)
8. Auto-immune diseases (T1-diabetes, Rheumatoid arthritis, Asthma, Multiple sclerosis) (Harmsen)
9. Microbiome and the Gut-Brain axis (El Aidy)
10. Microbiome and neurodegenerative disorders (El Aidy)
11. Microbiome interventions, FMT Pre and Probiotics (Harmsen)

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	Several Lecturers
Docent(en)	S. El Aidy, PhD.dr. ir. H.J.M. Harmsen
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Verslag (R)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification. Prior knowledge: Basic Cell & Molecular Biology, Physiology, Genetics, Ecology & Evolution, Microbiology, Biostatistics 1, Behavioural Neuroscience, Molecules of Life, Cell Biology & Immunology, Evolutionary Ecology, Biochemistry & Cell Biology, Metabolism, Bioinformatics
Opmerkingen	This course has two coordinators: S. El Aidy, PhD Dr H.J.M. Harmsen Tutorials are mandatory. In case of absence without prior permission and without a demonstrable valid reason, the practical cannot be completed. The course prepares an understanding of the general concepts in Host- gut microbe interactions and provides skills usable for various majors (Biomedical Sciences, Behavior and Neurosciences). At the end of the course the students are expected to have an overview for the multidisciplinary interactions between the human being and its gut microbes Dit vak had vorig jaar vakcode WBLS19012

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Human Genetics and Genomics

WBBY042-05

This course is a follow-up of the Basic Genetics course. Within the Basic Genetics course students got insight in the organization of
the genome in relation to genetic variation and in the importance of identification of disease genes. Techniques used to identify
genetic loci involved in monogenic diseases are discussed. Students learned to work with genome browsers and databases.
In this follow-up course the research done to identify disease genes for patients suspected of having a monogenic disease, but
without a genetic diagnosis, will be taught. Genetic complex diseases are discussed and which genomics techniques are used to
identify which genes and which molecular biological mechanisms are involved in the development of diseases.
During computer assignments students work with big datasets and by writing a research proposal the question is addressed when to
use which genomics methods and how these methods work. Ethical aspects about the use of genomics methods generating big data
sets in the clinic and research will be discussed.
Contents:
- genome wide association studies in large patient cohorts and controls to look for disease genes;
- expression profiling of human tissue to get to know which genes or pathways are changed in affected tissue;
- use of next generation sequencing in genetic research and diagnostics;
- clinical doctors and geneticists present how genomic data is used in a research setting to find new disease genes for clinical daily
practice (development of DNA diagnostics).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. C.C. van Diemen
Docent(en)	dr. C.C. van Diemen dr. H. Westers
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Practisch werk (PRC)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Capacity max: 60 Dit vak had vorig jaar vakcode WBLS19027

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Immunology

WBBY020-05

Immunology is the academic discipline that studies all aspects of the immune system. This course is the introductory course into Immunology. The course will describe the cells of the Immune System, their development, their organization into tissues, their activation, differentiation and their interactions that form the basis of the immune response. The course will introduce the student into the balance between immunity and tolerance. We will discuss the critical importance of the ability to induce an effective immune response against infectious pathogens such as viruses or bacteria, as well as the harmful consequences of autoimmune responses or unnecessary immunity against harmless environmental agents. The Immunology course aims to provide the student with both knowledge of and insight into the functioning of the immune system in health and disease.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G. van den Bogaart
Docent(en)	prof. dr. N.A. Bos prof. dr. P. Heeringa prof. dr. F.G.M. Kroese dr. ir. M.C. Nawijn prof. dr. G. van den Bogaart
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Meerkeuze toets (MC)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Capacity max: 200 students Lectures are not mandatory, but lecture slides are integral part of the study materials for the exam. The course unit prepares for and provides skills usable in the course unit: Immunology and Disease Dit vak had vorig jaar vakcode WBLS19013

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Immunology and Disease

WBBY043-05

The immune system is critical for combating infectious diseases, and its activity can be exploited for the treatment of numerous
diseases, including cancer. Dysregulated activity of the immune system lies at the heart of the pathogenesis of numerous diseases,
including auto-immune disorders, allergy, asthma, and cancer. Our insight into the immunological basis of these diseases and the
possibilities for rational design of innovative therapeutic strategies for their prevention or treatment is progressing at a rapid pace.
In this course, students will obtain basic theoretical knowledge regarding fundamental immunological mechanisms to combat
infections and their role in immune-mediated diseases. In addition, students will obtain theoretical knowledge regarding
immunological techniques and methods to analyse immune responses and how these can be applied for research, diagnostic and
therapeutic purposes. This knowledge will be imparted by overview lectures given by expert principal investigators of the UMCG and
the RUG. During the practicals, students will become familiar with the execution and application of antibody-based immunological
techniques including immunohistochemistry, enzyme-linked immunosorbent assay and flow cytometry.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. R.A. Bank
Docent(en)	prof. dr. C.A.H.H. Daemen prof. dr. P. de Vos prof. dr. A.L.W. Huckriede prof. dr. F.G.M. Kroese dr. B.J. Kroesen dr. ir. M.C. Nawijn dr. J.N.G. Oude Elberink dr. A. Rutgers prof. dr. C.A. Stegeman
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Practisch werk (PR)
ECTS	5
Entreevoorwaarden	Prior knowledge: Immunology (year 2, 1b) PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Capacity max: 50 students Practicals are mandatory. Consequence for missing practicals is that no final grade for the course will be given. Dit vak had vorig jaar vakcode WBLS19028

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Integrative Neuroscience

WBBY006-05

The second year course Integrative Neurosciences aims to deepen understanding of neurobiological mechanisms underlying complex
behavior and physiology, of which students have acquired basic knowledge during the first year courses “Behavioural Neuroscience”
and “Physiology”. In particular, a deepening of the role of sensory information processing through perception of taste and smell,
visual information, proprioception, pain/discomfort, are included in this integration, how these sensory information streams are
relayed and underlie complex regulatory mechanisms, including regulation of motivated behaviors, body posture and locomotion, and
how these process contribute to consciousness and speech. The nervous system will be viewed from different angles including
neuroanatomy, neurochemistry, neuroendocrinology, behavioral physiology, and neuropathology. These subjects are part of
neurosciences, which is viewed as an integrated entity. Besides the theoretical background, there is a number of practicals including
brain anatomy (BA; of the pig brain), dark adaptation in humans (DA), and taste/smell (TS) in humans, and assessing oestrus
cyclicity in rodents (OE).

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G. van Dijk
Docent(en)	prof. dr. E.A. van der Zee prof. dr. G. van Dijk
Onderwijsvorm	Practisch werk (PRC), Werkcollege (T), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Meerkeuze toets (MC), Practisch werk (PR), Presentatie (P), Tussentoets (IT)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The course Integrative Neuroscience builds on the knowledge gained in the first year courses “Behavioural Neurosciences” and “Physiology, within the degree program of Life Sciences. Integrative Neuroscience prepares students for neurobiological subjects within research courses in the third year of the majors Biomedical Sciences, Behavior and Neurosciences, Molecular Life Sciences and Integrative Biology. It also provides a basis for the master phase. Of the lectures, only the “Introduction” and “ethics on animal experimentation” are mandatory (IT).Students who miss out on mandatory lectures will get an alternative assignment. All practical assignments are mandatory. Students who miss out on practical assignments will have to redo these the next year. The book 'Neuroscience exploring the brain', 4th edition, 2016 by Bear, Connors, Paradiso (ISBN 978-1-4511-0954-2) is not mandatory. Dit vak had vorig jaar vakcode WBLS19004

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Medical Cell Biology

WBBY045-05

Description. Knowledge in cell biology is essential for fundamental and biomedical research. Thus, intracellular processes associated
to diseases are explained and subsequently discussed in the context of the development of diagnostic tools and therapies. The
proposed topics cover: 1) cell contacts and polarization, 2) neuroplasticity 3) protein folding, 4) degradation mechanisms, and 5)
stem cell biology. Each theme is connected to a specific diseases. Insights into the disease pathophysiology are also given during
the patient/clinical lectures.
The lectures will be organized into 4 blocks. A specific medical theme is central to each block. The clinical problems will be outlined
during the patient lectures. The 4 block lectures are concluded with two questions-answers sessions, where unclear points provided
by the students are discussed.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. M.C. Mari
Docent(en)	L. Barazzuol dr. S. Bergink prof. dr. R.P. Coppes G. Dijkstra dr. B.N.G. Giepmans dr. D.J. Heersema prof. dr. H.H. Kampinga dr. S.M. Kooistra dr. M.C. Mari prof. dr. F.M. Reggiori prof. dr. O.C.M. Sibon prof. dr. S.C.D. van Ijzendoorn
Onderwijsvorm	Opdracht (ASM), Werkcollege (T), Hoorcollege (LC)
Toetsvorm	Presentatie (P), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	There are no mandatory entrance conditions. However, the course requires prior knowledge of cell biology acquired from introductory courses of the bachelor program. Due to the medical situation of some patients, some Patient/Clinical lectures will be in given in Dutch but in that case a short summary in English will be provided to the students. In that case, the students will be still able to ask questions in English. All others lectures will be given in English. The slides used for accompanying all the lectures (including the Patient/Clinical lectures), will be in English.
Opmerkingen	Max 96 students. Patients/Clinicians lectures and Tutor group meetings (Newsflash), including plenary introductory lectures (course and Newsflash) and final symposium are mandatory. Missing more than one of Patients/Clinicians lectures or introductory lectures without (prior) acceptable justification, will lead to the exclusion of the student from the written exam or a default grade of 1 on the assignment. Additional lecturers: M.C. Bolling, R.J.H.M. Steenbakkers, I. Zuhorn en M. Hipps Dit vak had vorig jaar vakcode WBLS19030

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Medical Structural Biology

WBBY007-05

In this course students will get an overview of techniques used for structural characterization and analysis of protein-drug interactions. This will be preceded with an overview of general principles of organization of proteins and nucleic acids.
Topics will include structures of proteins (soluble and membrane-embedded) from the drug development point of view; basic principles of drug-protein interactions; biophysical methods to characterize drug-protein complex formation (X-ray crystallography, cryo-Electron Microscopy, Nuclear Magnetic Resonance), and an introduction into fragment based drug design and virtual screening.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. A. Guskov
Docent(en)	C. Batista Paulino, PhD. A.A. de Bruyn-Rybczynska, PhD.dr. A. Guskov dr. A.M.W.H. Thunnissen prof. dr. P.C.A. van der Wel
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Werkcollege (T)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	Basic knowledge of structures, chemical properties, and roles of the most important classes of biomolecules: DNA, RNA, and proteins acquired from ‘Molecules of Life’ and ‘Biochemistry’ courses. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Tutorials and a seminar are mandatory. The seminar is a mock examination. Tutorials are computer-based, where visualising the structures enables a deeper understanding of principles of structural organization of proteins and nucleic acids Not mandatory but recommended: "How Proteins work", Mike Williamson (2011). ISBN: 9780815344469 Dit vak had vorig jaar vakcode WBLS19005

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Minor congress (Life Sciences)

WBBY023-05

The student choses a scientific research question related to his/her minor and selects 3 recent scientific publications related to that research question. This selection of research papers is sent for approval to one of the teachers and subsequently the student writes a scientific essay using 1500 words max.
Using a peer-review procedure the student provides and receives critical feedback on the written essay and uses this feedback to improve the quality of his/her essay. The student also receives a training on how to professionally present scientific data which will be practiced on a student conference at the end of the course. Furthermore, the student will receive a training in how to write items for high-quality newspapers science sections and write a newspaper science section together with other students.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. B. Buwalda
Docent(en)	dr. B. Buwalda A.M. Engbersen Gastdocent(en)drs. L.T.J. Kraan dr. F.L. Kramer
Onderwijsvorm	Werkcollege (T), Hoorcollege (LC), Opdracht (ASM)
Toetsvorm	Opdracht (AST), Presentatie (P), Verslag (R)
ECTS	5
Entreevoorwaarden	No entrance requirements. The course assumes general pre-knowledge in communication skills (reading, writing and presenting) from year 1 and 2 of the bachelor programmes Biology and/or Life Science & Technology.
Opmerkingen	This course is compulsory for students who follow a minor programme within the life sciences. This course is not open to students who are following a degree programme other than Biology and/or Life Science & Technology. All lectures are mandatory. Tutorials and workshops are also mandatory. When tutorials or workshops are missed without approval at forehand, students fail their assignment and will need to redo this part of the course.

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Modelling Life

WBBY024-05

This course introduces students to the mathematical modelling of biological systems, and covers model development, analysis and
interpretation. In order to deal with variation in prior knowledge, students will have an opportunity to identify potential weak spots
in their understanding of mathematics, and develop necessary baseline skills in an e-learning environment (SOWISO), where
students are able to select personalised practice material based on the results of self-evaluation tests.
The new material covered in this course introduces mathematical tools to describe and analyse dynamical interactions and feedback
mechanisms in a wide variety of biological systems, including gene-regulation networks, nerve cells, hormonal control mechanism,
epidemics of infectious diseases and ecological interactions. Here, we will follow the textbook Modeling Life – The Mathematics of
Biological Systems (Garfinkel et al., 2017). Students learn how to develop dynamical models of biological systems and how to
determine their dynamical behaviour and equilibrium states, based on an analysis of system trajectories and the underlying vector
field. Qualitative (graphical) analysis and simulation are the main tools for generating biological insight; analytical methods are
introduced on a need-to-know basis.
Topics covered in this course include: ‘Dynamical modelling and simulation’, ‘Equilibrium behaviour’, ‘Non-equilibrium dynamics:
oscillations and chaos’, ‘Linear algebra’ and ‘Multi-variable systems’. Students prepare for each topic by reading sections of the book,
and are introduced to the new material in a lecture. Next, they develop an active understanding of each topic by working on pen-
and-paper and computer exercises, both individually and in a working-group setting. For each topic, one of the working-group
assignments has to be handed in for evaluation. The course is concluded with a written exam.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. G.S. van Doorn
Docent(en)	dr. A. Milias Argeitis prof. dr. G.S. van Doorn
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Schriftelijk tentamen (WE), Tussentoets (IT)
ECTS	5
Entreevoorwaarden	The course units assumes prior knowledge and skills, acquired from the following other course units and/or degree programmes : High-school mathematics (equivalent to VWO wiskunde A and/or B) PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The course provides students with broadly applicable quantitative and mathematical analytical skills; in particular, it prepares, for the courses Mathematics in the Life Sciences, Biostatistics II and Self-Organisation. Dit vak had vorig jaar vakcode WBLS19014

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Molecular Genetics

WBBY008-05

This is a follow-up course of the first-year courses Basic Cell and Molecular Biology, and Genetics, Ecology and Evolution. It covers
the main concepts of molecular genetic mechanisms in prokaryotic and eukaryotic organisms. Genome organization and integrity,
DNA damage and repair, homologous- and site-specific recombination, gene regulation, plasmid biology, genomics and -omics
techniques will be further deepened, while also the genetic organization and life cycle of retroviruses, temperate and virulent
bacteriophages will be dealt with. Resistance mechanisms against bacteriophages and the subsequent development of genetic
engineering and gene editing technology (CRISPR-Cas) will be exemplified.
The importance of molecular genetics in developments in Biotechnology, System- and Synthetic Biology and the impact that
molecular genetic techniques have in fundamental research, medicine, agriculture and society at large will be discussed.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. J. Kok
Docent(en)	P. Alvarez Sieiro, PhD. D. Incarnato, PhD.prof. dr. J. Kok
Onderwijsvorm	Hoorcollege (LC)
Toetsvorm	Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	The course units assumes prior knowlegde and skills, acquired from the following other course units and/or degree programmes: First-year courses Basic Cell and Molecular Biology; Genetics, Ecology and Evolution. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	The course unit prepares for and provides skills usable in the course unit(s) or degree programme(s): Genes and Behaviour; Evolutionary Processes; Bioinformatics; Human Genetics and Genomics; Epigenetics and Gene-editing; Evolutionary Medicine; Evolutionary and Ecological Genomics; Evolutionary medicine; Molecular Biology; Practical Carrousel; Bioanalytical and -omics Techniques Dit vak had vorig jaar vakcode WBLS19006

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Molecular Research in Human Disease

WBBY061-05

In this course (5 ECTS) the LS&T students are prepared for a research career in science. Students learn the necessary skills to
design and conduct scientific research. They are introduced into various molecular and biochemical techniques and learn about the
use of genetically engineered mouse models in unravelling the mechanism of human disease. Students will write an editorial based on
a high-impact scientific article and they will devise a research proposal for research into human diseases. Furthermore, students will
present their editorial and research proposal to learn to communicate their ideas effectively. Based on the principal of Problem Based
Learning, the students also have to solve three cases related to different diseases or aspects there off. In addition, they participate
in a 4-day practical session in which they produce results that have to be discussed in their case report. As a result, our course is
very different from the other courses in the Bachelor Programme and the students need to present an active attitude, a high level
of independence and intrinsic motivation to be able to successfully pass our course. Every single component is graded and thus, the
overall score is a good reflection of the student’s ability to be successful in a future scientific career.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. D.P.Y. Koonen
Docent(en)	Gastdocent(en)prof. dr. J.W. Jonker dr. D.P.Y. Koonen dr. J.K. Kruit prof. dr. F. Kuipers prof. dr. J.A. Kuivenhoven dr. ir. M.H. Oosterveer prof. dr. ir. A.J.A. van de Sluis dr. D.S. Verbeek dr. M. Westerterp
Onderwijsvorm	Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Presentatie (P), Verslag (R)
ECTS	5
Entreevoorwaarden	The course units assumes prior knowlegde and skills, acquired from the following other course units and/or degree programmes : Molecular Genetics, Research skills in Life Sciences PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Guest lectuers: Alain de Bruin (UU) Capacity: max. 20 students All parts are mandatory. Failure to present the editorial and research proposal will result in a 0 score on these items, unless the student can proof that absence was due to illness. In that case the student is entitled to present at a later time point. Dit vak had vorig jaar vakcode WBLS19043

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Neurobiology of Ageing

WBBY062-05

This course will provide a general introduction to the evolution of ageing, and will then focus on the neurobiology of ageing (brain ageing). It will include a more detailed introduction to brain ageing at the genetic, molecular, cellular, systemic, and behavioural level. Concepts of pathological and non-pathological ageing are discussed. Consequences of brain ageing for cognition, neurophysiology, nutrition, and signal transduction pathways are dealt with. In addition, topics such as blood flow and neuroinflammation will be taught in more detail. In addition it will address, among others, the following questions: Why do we age? What is the impact of (traumatic) early life events on brain ageing? How can we slow down brain ageing, and how do we recognize brain ageing? Can it be reversed if we know the underlying mechanisms? At what age does brain ageing start, and is this different for males and females?
Is it lifestyle-dependent? Hence, this course will provide a broad overview of issues that play a key role in brain ageing, its functional consequences and the underlying mechanisms. It will address both human and animal research in an integrated fashion.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. E.A. van der Zee
Docent(en)	Dr. R.G. Schoemaker prof. dr. E.A. van der Zee prof. dr. G. van Dijk prof. dr. S. Verhulst
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Practisch werk (PR)
ECTS	5
Entreevoorwaarden	Basic knowledge of Neurosciences is mandatory. This course prepares for research courses at the end of the third year as well as master projects in year 4/5. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	If a student misses a module (or several), a second options to do it is provided at the end of the course. If a module is still not performed, an extra literature assignment can replace the missing modulel (depending on the reason why the student missed all other options). The final consequence for missing out the modules and a potential extra assignment is to redo it next year. Dit vak had vorig jaar vakcode WBLS19044

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Practical Carrousel

WBBY048-05

Over the last decades, technological innovations in the manipulation and sequencing of DNA, protein engineering and structural
biology, electrophysiology and biological spectroscopy have led to scientific breakthroughs that allowed drastic changes in medicine,
agriculture and biotechnology. These innovations were based on our current understanding of the role of molecular processes in the
cell and their interplay. This essential knowledge was and is continued to be created through laboratory experimentation. To
understand and contribute to such developments in Molecular Life Sciences, it is essential that students are trained in modern
experimental strategies and laboratory protocols. Accordingly, the Practicum Carousel allows the students to become familiar with
various laboratory methods and in-silico tools that are frequently used in molecular and cell biology research. The course prepares
for BSc research projects, the participation in iGEM (the genetically engineered machine competition) and (later) master research in
GBB research groups that investigate cellular and/or molecular processes in isolated or more complex biological systems.
The students will be trained in planning and executing experiments that are more advanced and less routine than what is taught in
the earlier courses in the curriculum. The emphasis is on learning when and how to use specific genetic and biochemical techniques.
To ensure that students learn a diversity of approaches and methods, they will perform three extended experiments, each for one
week. The 1-week experiments are in the following fields:
1. enzymology and biocatalysis, with students learning to investigate and understand how to (re)design the catalytic power of
enzymes
2. cell biology, with students learning experimental methods to unravel the complexity of cellular processes and regulation of
metabolism
3. molecular genetics, offering students to obtain hands-on experience with modern tools in gene- or genome edititing

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	S.K. Billerbeck, PhD.
Docent(en)	P. Alvarez Sieiro, PhD.prof. dr. ir. M.W. Fraaije prof. dr. J. Kok prof. dr. I.J. van der Klei
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Practisch werk (PR), Schriftelijk tentamen (WE)
ECTS	5
Entreevoorwaarden	PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification. Students should have knowledge of general biochemistry and molecular biology, including flow of genetic information, molecular genetics, and cell biochemistry. Students are expected to be familiar with the chapters "Exploring Genes" and "Exploring Proteins", in Berg et al., Biochemistry, Wiley (7th or 8th Ed.), the theory within T.A Brown's Genomes 4, Garland Science (4th Ed) and with the theoretical background of basic laboratory methods in gene cloning and analysis, enzymology, and protein analysis. Year-1 courses in the curriculum Molecular Life Sciences should have been completed.
Opmerkingen	Capacity max: 48 students The course is open to students in Molecular Life Sciences and Molecular Biology with a good basic level of understanding of biochemistry and molecular biology. Structures of proteins, flow of genetic information and overall metabolism, and basic genetic engineering and bioorganic chemistry should be known. All parts are mandatory, full attendance is required. Dit vak had vorig jaar vakcode WBLS19032

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Programming for Life Sciences

WBBE022-05

The course aims to teach students how to solve (research related) problems using a computer. This course prepares students for all programmes where research involves repetitive and/or large scale data processing using computers.

The lectures focus on explaining new programming language constructs, some of which will be reinforced during tutorial sessions,
and the students will subsequently practice applying these concepts in the computer practicals. This includes new programming
techniques or background information and further explanation of the experimental data to be processed. During the computer
practicals, students will write small Python programs, demonstrating their ability to correctly and efficiently solve a specific problem.
TAs will provide feedback. The problems students are presented with typically involve importing, visualizing, analysing, and
processing experimental data. Where possible, assignments dovetail with the students' experience and interests, and may come from
subject fields such as biophysical chemistry, spectroscopy, reaction kinetics, MRI, fluorescence microscopy, bioinformatics,
structural biology, molecular dynamics, etc. Interesting topics suggested by students will also be considered.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	prof. dr. S.J. Marrink
Docent(en)	PhD. P.C. Kroon T.A. Wassenaar, PhD.
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC), Werkcollege (T)
Toetsvorm	Opdracht (AST), Tussentoets (IT)
ECTS	5
Entreevoorwaarden	Some of the assignments require basic knowledge of mathematics (basic algebra, basic understanding of vectors and matrices), biology (basics of biochemistry), and physics (classical mechanics) at high school level. PLEASE NOTE Biology and Life Science & Technology (old curriculum) course units are only accessible for students of those degree programmes. Students from other degree programmes who would like to participate in Biology course units are obliged to contact one of the academic advisors before registration. After this contact, students have to request admission from the Board of Examiners Biology/Life Science & Technology. Failing to follow this procedure results in immediate unenrollment without prior notification.
Opmerkingen	Capacity: max. 70 students. Dit vak had vorig jaar vakcode WLB07100

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Research Project Molecular Life Sciences

WBBY904-10

Students choose a Bachelor’s Research Project from an overview of possible topics within the major. The topics are grouped in clusters. Two students are assigned to one project and will conduct the experiments together under the guidance of one or more supervisors. First, after meeting with their supervisor(s), receiving an overview of the project and start-up literature, the students will start developing a project plan. This entails individual work on writing an introduction to the project and a research proposal. The proposals of both students are discussed together with the supervisor and a final version of a project plan is designed. The students execute the experiments as a team to collect and analyze the data. The findings are presented during a final meeting of all projects in the cluster and the conclusions are discussed with fellow students and the associated supervisors. Each student writes a scientific report on the Bachelor’s Research Project, in which the material and methods as well as the results can be shared between the two team members, whereas the introduction and discussion are individually composed.

Faculteit	Science and Engineering
Voertaal	Engels
Coordinator	dr. E. Geuverink
Docent(en)	P. Alvarez Sieiro, PhD. Several Lecturers
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC)
Toetsvorm	Practisch werk (PR), Presentatie (P), Verslag (R)
ECTS	10
Entreevoorwaarden	All students need to have obtained the following entrance conditions: - a total of 90 ECTS; - including the propaedeutic phase of the bachelor programme Biology; - excluding minor programme. Research projects are not open to students from other programmes than the bachelor Biology and/or Life Science & Technology.
Opmerkingen	Teaching method: 5h will be spent on introductory/background lectures or seminars, 35-55h will be spent on collecting and reading background literature, developing the research questions, planning the experiments and writing an introduction to the project, 140-180h will be spent on conducting the experiments and analyzing the data, 60-80h will be spent on interpreting the results, writing the report, preparing the oral presentation, and participating in group discussions and/or tutor groups during the project period. Questions about the organisation/structure of the research project, contact Elzemiek Geuverink. Questions about the content of the research project, contact Patricia Alvarez Sieiro.

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