Receptor Pharmacology

Uitgebreide vaknaam	Receptor Pharmacology
Leerdoelen	To acquire more in-depth pharmacological knowledge after the students were introduced to the basic principles of pharmacy during their first year. After completion of this course unit, students will be able to: 1. explain the relationship between ligand-receptor binding and effect 2. explain the functioning of receptors, including ion channels, G protein-coupled receptors, receptor tyrosine kinases, cytokine receptors and nuclear receptors 3. compare the molecular mechanism underlying neurotransmission and the related physiological effects in the autonomic and somatic nervous systems 4. explain the metabolism and the functioning of histamine and autacoids 5. compare the molecular mechanisms involved in effects of pharmaceuticals on the above systems 6. explain the application of specific pharmaceuticals in the treatment of organ-related diseases. (These six learning outcomes will be addressed sufficiently if Chapters 2-4, 12-17, 20, 26, 29, 39-42, 47 and 57 (parts of, as indicated on Nestor) of Rang & Dale's Pharmacology (8th edition) and the lecture files are studied.)
Omschrijving	During the first semester of the propaedeutic phase, students were introduced to the main principles in physiology including defence mechanisms and immunology, and developed the ability to understand and explain these principles in the treatment approach of pathologies using pharmacological interventions, with a special focus on diabetes mellitus. In this course unit, more attention will be paid to the underlying mechanisms that play a role in our body’s functioning in healthy situations and when affected by diseases. It concerns a more in-depth study of the treatment approach to diseases by pharmacists. The following topics will be addressed in this course unit: - key definitions in pharmacology: pharmacodynamics versus pharmacokinetics - the functional mechanisms of pharmaceuticals and pharmacological definitions: agonist, antagonist, inverse agonist, receptor reserve, receptor regulation (desensitization, up/down regulation) - signal transduction mechanisms: G protein-coupled receptors, ligand-gated ion channels, kinase-coupled receptors, nuclear receptors, crosstalk between signal transduction mechanisms, the function of arrestins, ubiquitylation - basic principles of neurotransmission: presynaptic and postsynaptic receptors, co-transmission - receptor subtypes and signal transduction: the cholinergic, adrenergic, serotonergic, dopaminergic, histaminergic and purinergic systems - function of autacoids and their receptors, non-steroidal anti-inflammatory drugs (NSAIDs), the functioning of local anaesthetics. This course unit dovetails with the learning outcomes a, b, d, f, g, i and j of the Bachelor’s degree programme in Pharmacy (OER Appendix I).
Uren per week
Onderwijsvorm	Hoorcollege (LC) (Hoorcolleges: 42 uur; zelfstudie: 98 uur)
Toetsvorm	Meerkeuze toets (MC), Schriftelijk tentamen (WE) (The entire course unit will be assessed by means of an examination comprising 40 multiple-choice questions and 2 essay questions. The multiple-choice questions will count for 2/3 of the final mark and the essay questions for 1/3. Students will have 3 hours to complete the examination. To assess all learning outcomes in a balanced manner, all chapters and lecture files must be addressed in the examination.)
Vaksoort	propedeuse
Coördinator	prof. dr. R. Gosens
Docent(en)	prof. dr. A.M. Dolga ,prof. dr. R. Gosens ,prof. dr. M. Schmidt
Verplichte literatuur	Titel Auteur ISBN Prijs Lecture files (via Nestor) Rang & Dale's Pharmacology (8th or 9th edition) Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G
Entreevoorwaarden	The course unit assumes prior knowledge from the Physiology and Pharmacology course unit (WPFA18005). This course unit is an entry requirement for the Pharmacology Practical (WLFB0705).
Opmerkingen	Random chance + realistic knowledge rate / 100 * ((multiple-choice questions - random chance) + essay question 1 + essay question 2) Mark: If the score < pass mark: mark = 1.0 + 4.5 * (score - random chance) / pass mark - random chance If the score > pass mark: mark + 5.5 4.5 * (score - random chance) / number of questions - pass mark) Determination of the final mark for the course unit: the knowledge percentage is set at 55% and the pass mark is subsequently calculated, corrected for random chance. Marks over or equal to 5.5 are a pass and all marks below 5.5 are a fail. The average mark will be rounded off to the nearest whole or half mark; a mark of 5.5 will not be given. Students who fail the examination must take a resit.
Opgenomen in	Opleiding Jaar Periode Type BSc Pharmacy  (hoofdprogramma) 1 semester II b verplicht