Applied Biocatalysis and Bioconversion

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WMIE14003
Vaknaam Applied Biocatalysis and Bioconversion
Niveau(s) master
Voertaal Engels
Periode semester II a

Uitgebreide vaknaam Applied Biocatalysis and Bioconversion
Leerdoelen At the end of the course, the student is able to:
1.write a compact review on enzymes and enzyme classification, based on scientific literature (attainment level 2) (part of introduction case-report biocatalysis)
2.write a compact review on microbial conversions in biogeochemical cycles based on scientific literature (attainment level 2) (part of introduction case-report bioconversion)
3.identify the advantages and disadvantages of using enzymes/micro-organisms in a specific industrial process (selected cases) and how to control/counteract them (attainment level 3). an industrial bioconversion and biocatalysis process (on selected cases) (attainment level 3).
5.synthesize a strategy on how to implement his/her designed processes in practice (technological and economic feasibility) (attainment level 5 and 6)
6.write a report on both the biocatalysis case study and a report on the bionversion case addressing the above mentioned skills (attainment levels 2,3,4, 5 and 6)
7.present his/her results to the peers and stakeholders (attainment level 6).
Omschrijving This module will cover different topics in the practical use of microorganisms or enzymes in various industrial processes ranging from the production of specific food ingredient components such as flavor and coloring compounds, the production of advanced antibodies or advanced pharmaceutical ingredients to the large scale use of micro-organisms in cleaning up polluted soils and waste water treatment.
The course starts with a short introduction to the basic principles underlying a specific application followed by an overview on the practical use. Students will be given assignments to work on in individually or in small groups (depends on number of students for the course) and present the findings to the other students in meetings. Each student has to hand in two written reports, one on general aspects of bioconversion-principles and in depth presentation of a bioconversion case, and one on biocatalysis (both general aspects as well as in-depth description of biocatalysis case).
Uren per week
Onderwijsvorm Bijeenkomst (S), Hoorcollege (LC), Opdracht (ASM), Werkcollege (T)
(Lectures: 2 hours, Seminars: 12 hours, Prep. presentation: 20 hours, Assignments: 104, Self study: 2 hours.)
Toetsvorm Presentatie (P), Verslag (R)
(Two case reports (80% - each 40%) and a presentation to peers & stakeholders (20%).)
Vaksoort master
Coördinator dr. J. Krooneman
Docent(en) dr. J. Krooneman ,prof. dr. M.J.E.C. van der Maarel
Verplichte literatuur
Titel Auteur ISBN Prijs
This will be a short list on up-to-date relevant scientific literature, provided prior to the course via nestor.
Entreevoorwaarden The course unit assumes prior knowledge acquired from “Introduction to organic chemistry and biochemistry (e.g. Structures and Molecules, Biological Systems)” obtained during bachelor degree program of IEM.

General assignments
1. Enzyme classification
Enzymes are grouped into 6 main classes by the International Enzyme Commission (E.C. numbers). Please describe how the enzyme classification system works and pay attention to the general principles of the classification and the use of common and systematic names, including at least two examples of an enzyme’s common and corresponding systematic name. In addition, also give a general description of each one of the six classes and describe in detail the naming and working mechanism of one particular enzyme per class.
2. Biogeochemical cycles in Nature.
The major elements C (carbon), S (sulphur), N (nitrogen), and P (Phosphor) are present in various forms in Nature as they move through biotic and abiotic compartments on our Planet. Please describe the biogeochemical cycles for these 4 elements and pay special attention to the role of microorganisms in these cycles.
For each assignment, hand in a written report of at least 4 A4 pages (font size 11 times new roman, margins 2 cm) excluding figures and reference list. You are requested to use at least three scientific papers per report; this can be review papers and/or experimental papers (not book chapters!!). The reports will be graded by the course coordinator.
Opmerkingen Cases (assignments)
Each participant in the course handles two cases (selected from a list of case-topics provided early in the course during a lecture); one on biocatalysis and one on bioconversion. For each case a presentation (in any form) has to be given to the other participants. The presentation will be graded (using grading form) by the fellow participants as well as by the course coordinator and experts from the field that will be invited by the course coordinator. In addition, a written report has to be made in which a detailed description of the biological principle (e.g. enzyme action, mechanism, or type of microorganisms and their metabolism) has to be given as a well description of the problem/challenge/production process/product (whatever applicable) has to be presented. For this part at least three scientific papers and/or patent applications have to be used and discussed. Finally, a short description of one or more companies producing or using the biological systems and any information on the product/process specification, marketing/advertisement/trade names etc. that can be found on the Internet has to be included The case reports will be reviewed by 2 fellow students that will give feedback and a grade. In addition, the course coordinator will grade the reports, taking the grades that the fellow students gave into account. At least 3 A4 pages (font size 11 times new roman, margins 2 cm) excluding figures and reference list.

Final grade: general assignments: presentation:20%, case reports: each 40%. Grades given by students will be taken into account by the coordinator for the grading of the final marks. The minimal mark for each case study is 6.0.
Opgenomen in
Opleiding Jaar Periode Type
MSc Industrial Engineering and Management: Product and Process Technology  (Optional technical PPT modules) - semester II a Elective BT