Synthetic Biology and Systems Chemistry

Faculteit Science and Engineering
Jaar 2019/20
Vakcode WMCH13002
Vaknaam Synthetic Biology and Systems Chemistry
Niveau(s) master
Voertaal Engels
Periode semester II a

Uitgebreide vaknaam Synthetic Biology and Systems Chemistry
Leerdoelen After participating in this course the students should
1. be able to describe and explain concepts behind
a. synthetic chemical networks, their properties, their behaviors and their analysis
b. behind genetic circuits, their engineering and application in synthetic biology
c. behind metabolic networks, their analysis, their behavior and engineering
2. be able to analyse the literature and extract relevant information
Omschrijving This course is meant for: 1) master students Chemistry in the track “Chemical Biology”, 2) master students of the GBB Top-program Biomolecular Sciences; 3) master students Molecular Biology and Biotechnology; 4) master students in Physics.

This course focuses on the principles and basics of molecular networks, their investigation and their engineering. Three molecular networks with increasing complexity will be covered in the course:
Part 1: Synthetic chemical networks (Otto; 6 lectures)
Part 2: Genetic regulation networks (Heinemann, 3lectures)
Part 3: Metabolic networks (Heinemann, 3 lectures)
Common to the discussed systems are the emerging phenomena: oscillations, multistability, feedback regulation, noise, etc.
Uren per week
Onderwijsvorm Bijeenkomst (S), Hoorcollege (LC), Practisch werk (PRC)
(Total hours of lectures: 12x90min., tutorial: discussions: 3x90 min., presentations: 3x90 min.)
Toetsvorm Practisch werk (PR), Presentatie (P), Schriftelijk tentamen (WE)
Vaksoort master
Coördinator Prof. Dr. M. Heinemann
Docent(en) Prof. Dr. M. Heinemann ,Dr. A. Milias Argeitis ,prof. dr. S. Otto
Verplichte literatuur
Titel Auteur ISBN Prijs
Hand outs will be provided as readers.
Entreevoorwaarden Knowledge of biochemistry as treated in “Biochemistry” (i.e. Stryer, 6th Edition)
Opmerkingen The result of the written exam and the performance during the literature discussions and presentations, as well as the computer practicals determines the mark of this course. The written exam counts 75%; the performance in the literature discussions, presentations and computer practicals counts 25% towards the final mark.
Opgenomen in
Opleiding Jaar Periode Type
MSc Biomolecular Sciences  (Electives/Optional modules) - semester II a keuze
MSc Biomolecular Sciences  ( Compulsory courses Chemical Biology) - semester II a verplicht
MSc Chemistry: Advanced Materials  (Electives) - semester II a keuze
MSc Chemistry: Catalysis and Green Chemistry  (Electives) - semester II a keuze
MSc Chemistry: Chemical Biology  ( Core Programme) - semester II a verplicht
MSc Chemistry: Chemical Biology  (Electives) - semester II a keuze
MSc Chemistry: Erasmus Mundus Theoretical Chemistry and Computing Modelling  (Electives) - semester II a keuze
MSc Chemistry: Science, Business and Policy  (Electives) - semester II a keuze
MSc Nanoscience  (Optional Courses) - semester II a keuze