Hematopoietic Stem Cells, Differentiation and Development

Uitgebreide vaknaam	Hematopoietic Stem Cells, Differentiation and Development
Leerdoelen	At the end of the course, the student is able to: 1. Describe the human hematopoietic system 2. Describe molecular mechanisms that underlie hematopoietic stem cell self-renewal and differentiation 3. Describe molecular mechanisms that underlie the development of hematological malignancies such as leukemias 4. Describe clinical aspects of hematological malignancies: current state-of-the-art regarding diagnosis and treatment 5. Read and discuss scientific articles related to the hematopoietic system as described above 6. Write an essay on a hematopoietic malignancy describing “what we know now and what we do not know yet but should know in order to improve treatment outcome”.
Omschrijving	Within this course we will study how hematopoietic stem cells (HSCs) are generated during embryogenesis and development, and how we can make HSCs from embryonic stem cells or induced pluripotent stem cells. We will study the molecular mechanisms that underlie the self-renewal properties of HSCs, and which molecular mechanisms drive differentiation of HSCs towards mature erythrocytes, blood platelets and innate or adaptive immune cells. We will focus on signal transduction initiated by cytokines and growth factors but also on epigenetic mechanisms that control the fate of HSCs. Furthermore, we will focus on malignant hematopoiesis and outline the diseases associated with aberrant blood formation. This will include chronic and acute myeloid and lymphoid leukemias, hodgkin and non-hodgkin lymphomas, multiple myeloma and anemia. What are the molecular mechanisms that drive these diseases? What do we know about the role of long non-coding RNAs? What is the role of epigenetics? We will also discuss the clinical aspects of these diseases in detail. What are the latest diagnostic tools? What are the current state-of-the–art treatment options, what are bone marrow stem cell transplantations, and what about immune therapy to treat hematological malignancies? What is the current status of small molecules directed against specific mutations, and have they reached the clinic yet? Besides in-depth lectures students will work in groups of 4 students to write an essay on a specific hematological malignancy. What are the genetic/epigenetic causes of the disease? How is the disease diagnosed and what are current treatment options? Do they work? If not, why not? And where should future research focus on in order to improve treatment outcome? At the end of the course the students will present and discuss their essay with the rest of the students and make a case as to why future EU funding should be made available for that particular hematological malignancy.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Opdracht (ASM), Practisch werk (PRC) (4 open quistions 21% (30% of exam), 35 mc questions 40% (70% of exam), Presentation/discussion of essay 10%, Assessment form 10%, Essay 10%. Final grade needs to be higher than 5.5)
Toetsvorm	Meerkeuze toets (MC), Opdracht (AST), Practisch werk (PR), Presentatie (P), Schriftelijk tentamen (WE) (Student listens and actively participates in lecture 22 hrs, Student will read articles related to a hematological malignancy, write an essay, and present and discuss findings for the rest of the class 40 hrs, Coaching, discussion with supervisor to discuss progress of assignment 2 hrs, Microscopy practical course in which differences in morphology of normal and leukemic cells are taught in order to show the latest in diagnostics and therapy 8 hrs, Self study 68 hrs.)
Vaksoort	bachelor
Coördinator	prof. dr. J.J. Schuringa
Docent(en)	dr. M. Bellido Casado ,dr. C.W. Choi , Gastdocent(en) ,prof. dr. G.A. Huls ,dr. A.B.U. Makelburg ,dr. A.B. Mulder ,prof. dr. J.J. Schuringa ,dr. T. van Meerten
Verplichte literatuur	Titel Auteur ISBN Prijs Slides on Nestor provided by teachers EHA roadmap paper (http://www.ncbi.nlm.nih.gov/pubmed/26819058)
Entreevoorwaarden
Opmerkingen	Presence during (parts of) the course is mandatory. The consequences for missing out on them are: -introduction lecture (again enroll in course next year) -practical microscopy course (repeat the practical course next year) -final presentations (again participate in presentations next year) Capacity max: 30 students The course unit if (often) followed by students from the course unit(s) and degree programme(s): MS Current Themes in Cancer, MS Biology of Ageing
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Biomedical Sciences 2 semester II b keuzegroep BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester II b keuzegroep