Bio-organic Chemistry

Uitgebreide vaknaam	Bio-organic Chemistry
Leerdoelen	At the end of the course students should be able to: 1. name and draw structures of molecules containing functional groups, including conformations and configurations 2. explain and recognize the different types of elimination and addition reactions in simple organic molecules 3. define the concepts of conjugation and aromaticity and recognize these concepts in given organic molecules 4. describe the mechanism of electrophilic aromatic substitution and apply this in synthesis 5. define the regioselectivity pattern of electrophilic aromatic substitution in substituted benzenes 6. reproduce and recognize addition reactions on aldehydes, ketones, carboxylic acid derivatives and alpha,beta unsaturated carbonyl compounds including imine formation, (hemi)-acetal formation and conjugate addition 7. recognize and apply enol and enolate formation of aldehydes, ketones and carboxylic acid derivatives in the formation of carbon-carbon and carbon-hydrogen bonds 8. recognize and apply the concepts presented in the points 1-7 to (straightforward) carbohydrates thereby understanding the metabolism of carbohydrates. 9. recognize and apply the concepts presented in the points 1-7 to amino acids, peptides, glycolysis pathway and the citric acid cycle.
Omschrijving	The aim of this course is to gain insight in a number of important reactivity principles in Bio-organic Chemistry. A focal point is the understanding and the application of several reaction types that form the basis of cell metabolism, and to get insight in the structure and reactivity of molecules. Function and reactivity of molecules is discussed in the context of the living cell.
Uren per week
Onderwijsvorm	Hoorcollege (LC), Werkcollege (T) (Total hours of lectures: 12*2 hours, tutorials: 12*2 hours, selfstudy: 90 hours)
Toetsvorm	Schriftelijk tentamen (WE) (The final mark is the mark of the exam (essay questions))
Vaksoort	bachelor
Coördinator	prof. dr. M.D. Witte
Docent(en)	prof. dr. M.T.C. Walvoort ,prof. dr. M.D. Witte
Verplichte literatuur	Titel Auteur ISBN Prijs Organic Chemistry (8th edition), Pearson Prentice Hall, or if needed, the 7th edition P.Y. Bruice 9781292160344 Buying the "Study guide and solution manual organic Chemistry- ISBN-10: 1292160438 • ISBN-13: 9781292160436" is highly recommended. P.Y. Bruice 9781292160436
Entreevoorwaarden	No mandatory prerequisites.
Opmerkingen	The courses within the bachelor programmes Biology and Life Science & Technology are open to students of those degree programmes only. Students from other degree programmes may be unenrolled. Please contact the academic advisors of Biology/LST first. The final mark is the mark of the exam. It is estimated that 50% of the exam is testing whether the student can reproduce the content of the course, 40% whether the student can apply the content (solving problems), and 10% whether the student has deeper insight and abstraction. The book and answer book will be available through the student unions and is identical to the book used for Molecules & Reactivity. It is not permitted to take this course unit together with Pharmaceutical Biosynthesis (WBFA16005, Pharmacy) in a single Bachelor’s programme because of too much overlap in the curriculum.
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Biomedical Sciences 2 semester II b keuzegroep BSc Biology: major Molecular Life Sciences 2 semester II b verplicht BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester II b keuzegroep BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester II b verplicht