Practical Carrousel

Uitgebreide vaknaam	Practical Carrousel
Leerdoelen	At the end of the course, the student is able to: 1. perform laboratory experiments: being able to plan, carefully execute, and evaluate experiments in the area of molecular genetics, enzymology and cell biology with the help of genetic, microscopic and biochemical techniques. 2. show the ability to report on and discuss experiments: examine and interpret results with (if necessary) the help of scientific literature. Being able to critically evaluate their own work and work of others in a team.
Omschrijving	Over the last decades, technological innovations in the manipulation and sequencing of DNA, protein engineering and structural biology, electrophysiology and biological spectroscopy have led to scientific breakthroughs that allowed drastic changes in medicine, agriculture and biotechnology. These innovations were based on our current understanding of the role of molecular processes in the cell and their interplay. This essential knowledge was and is continued to be created through laboratory experimentation. To understand and contribute to such developments in Molecular Life Sciences, it is essential that students are trained in modern experimental strategies and laboratory protocols. Accordingly, the Practicum Carousel allows the students to become familiar with various laboratory methods and in-silico tools that are frequently used in molecular and cell biology research. The course prepares for BSc research projects, the participation in iGEM (the genetically engineered machine competition) and (later) master research in GBB research groups that investigate cellular and/or molecular processes in isolated or more complex biological systems. The students will be trained in planning and executing experiments that are more advanced and less routine than what is taught in the earlier courses in the curriculum. The emphasis is on learning when and how to use specific genetic and biochemical techniques. To ensure that students learn a diversity of approaches and methods, they will perform three extended experiments, each for one week. The 1-week experiments are in the following fields: 1. enzymology and biocatalysis, with students learning to investigate and understand how to (re)design the catalytic power of enzymes 2. cell biology, with students learning experimental methods to unravel the complexity of cellular processes and regulation of metabolism 3. molecular genetics, offering students to obtain hands-on experience with modern tools in gene- or genome edititing
Uren per week
Onderwijsvorm	Hoorcollege (LC), Practisch werk (PRC), Werkcollege (T) (LC-6hrs; T-38 hrs; PRC-70 hrs; Self-study-26 hrs)
Toetsvorm	Opdracht (AST), Practisch werk (PR), Schriftelijk tentamen (WE) (A pass (at least 6) is required for all three areas of assessment, the exam, the laboratory performance and the lab journal. WE-30%; AST-30%; PR-40%)
Vaksoort	bachelor
Coördinator	S.K. Billerbeck, PhD.
Docent(en)	S.K. Billerbeck, PhD. ,prof. dr. ir. M.W. Fraaije ,prof. dr. J. Kok ,prof. dr. I.J. van der Klei
Verplichte literatuur	Titel Auteur ISBN Prijs Laboratory protocols Course coordinator and lecturers Course syllabus Curse coordinator and lecturers Biochemistry - Chapters "Exploring Genes" and "Exploring Proteins" (7th or 8th Ed.) Berg et al. Genomes 4, Theory on Genetic Flow (4th Ed.) T.A. Brown
Entreevoorwaarden
Opmerkingen	Capacity max: 48 students The course is open to students in Molecular Life Sciences and Molecular Biology with a good basic level of understanding of biochemistry and molecular biology. Structures of proteins, flow of genetic information and overall metabolism, and basic genetic engineering and bioorganic chemistry should be known. All parts are mandatory, full attendance is required.
Opgenomen in	Opleiding Jaar Periode Type BSc Biology: major Molecular Life Sciences 2 semester II a verplicht BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester II a verplicht