Molecular Genetics

Uitgebreide vaknaam	Molecular Genetics
Leerdoelen	At the end of the course, the student is able to: 1. Explain the main concepts of molecular genetic mechanisms in prokaryotes and eukaryotes 2. Describe the genetic organization and life cycle of retroviruses, temperate and virulent bacteriophages, and the resistance against the latter 3. Explain the main DNA manipulation, genetic engineering and gene editing techniques 4. Relate Molecular Genetics to developments in Biotechnology, System- and Synthetic Biology 5. Explain how animals are cloned and what the role and issues of epigenetic modifications therein are 6. Describe the main ‘omics’ techniques, such as transcriptomics, DNA-seq, RNA-seq and proteomics
Omschrijving	This is a follow-up course of the first-year courses Basic Cell and Molecular Biology, and Genetics, Ecology and Evolution. It covers the main concepts of molecular genetic mechanisms in prokaryotic and eukaryotic organisms. Genome organization and integrity, DNA damage and repair, homologous- and site-specific recombination, gene regulation plasmid biology, genomics and “omics” techniques will be further deepened, while also the genetic organization and life cycle of retroviruses, temperate and virulent bacteriophages will be dealt with. Resistance mechanisms against bacteriophages and the subsequent development of genetic engineering and gene editing technology (CRISPR-Cas) will be exemplified. The importance of molecular genetics in developments in Biotechnology, System- and Synthetic Biology and the impact that molecular genetic techniques have in fundamental research, medicine, agriculture and society at large will be discussed.
Uren per week
Onderwijsvorm	Hoorcollege (LC) (Lectures 30 hrs)
Toetsvorm	Schriftelijk tentamen (WE) (WE (100%) consists of open questions and multiple-choice questions.)
Vaksoort	bachelor
Coördinator	prof. dr. J. Kok
Docent(en)	D. Incarnato, PhD.
Verplichte literatuur	Titel Auteur ISBN Prijs Genomes, 4th edition Terry Brown Scientific papers (Posted on Student Portal) Molecular Biology of the Cell, 6th edition, year 2015 Alberts et al.
Entreevoorwaarden
Opmerkingen	The course units assumes prior knowlegde and skills, acquired from the following other course units and/or degree programmes: First-year courses Basic Cell and Molecular Biology; Genetics, Ecology and Evolution. The course unit prepares for and provides skills usable in the course unit(s) or degree programme(s): Genes and Behaviour; Evolutionary Processes; Bioinformatics; Human Genetics and Genomics; Epigenetics and Gene-editing; Evolutionary Medicine; Evolutionary and Ecological Genomics; Evolutionary medicine; Molecular Biology; Practical Carrousel; Bioanalytical and -omics Techniques
Opgenomen in	Opleiding Jaar Periode Type BSc Biologie of LS&T: Major Biomedische Wetenschappen (cohort 2016 en 2017)  (Minor Biomedische Wetenschappen en Gedrag en Neurowetenschappen) 3 semester I a keuzegroep BSc Biologie of LS&T:Major Moleculaire Levenswetenschappen (cohort 2016 en 2017)  (Minor Moleculaire Levenswetenschappen) 3 semester I a verplicht BSc Biology: major Behaviour and Neurosciences 2 semester I a verplicht BSc Biology: major Biomedical Sciences 2 semester I a verplicht BSc Biology: major Integrative Biology 2 semester I a verplicht BSc Biology: major Molecular Life Sciences 2 semester I a verplicht BSc LS&T: Major Medisch Farmaceutische Wetenschappen (cohort 2016 en 2017)  (Minor Farmacie) 3 semester I a keuzegroep BSc LS&T: major Behaviour and Neurosciences (cohort 2018 and 2019) 2 semester I a verplicht BSc LS&T: major Biomedical Sciences (cohort 2018 and 2019) 2 semester I a verplicht BSc LS&T: major Molecular Life Sciences (cohort 2018 and 2019) 2 semester I a verplicht