Reaction Mechanisms

Faculteit Science and Engineering
Jaar 2019/20
Vakcode CHORM05E
Vaknaam Reaction Mechanisms
Niveau(s) master
Voertaal Engels
Periode semester I a

Uitgebreide vaknaam Reaction Mechanisms
Leerdoelen At the end of the course, the student is able to:

use electron pushing for the analysis and description of reaction mechanisms.

know the detailed mechanisms of the most important organic reactions: addition and elimination reactions and substitution reactions.

know the mechanisms of the most important radical reactions, thermal rearrangements and isomerizations as well as pericyclic reactions.

propose reaction mechanisms using the tools of mechanistic organic chemistry, including Bronsted and Hammett relationships, More O’Ferrall– Jencks diagrams, kinetic isotope effects, isotope labeling, solvent effects, rate equations, the Hammond postulate, FMO analysis, orbital and state correlation diagrams, aromatic transition-state theory and the Woodward-Hoffmann
Omschrijving This course analyses in detail the mechanisms of organic reactions. Tools for rationalizing and predicting the reactivity of molecules will be explained, including kinetic isotope effects, Hammett correlations, Bronsted acid/base catalysis, isotopic labeling. These tools will be used to analyze the mechanisms of several important reactions and processes that form the core of organic chemistry, including addition, elimination and substitution reactions, isomerization and rearrangement reactions and thermal pericyclic reactions as well as radical reactions. Among the various main concepts, theories, and underlying kinetic and thermodynamic aspects that will be dealt with are: pushing electrons, orbital interactions, aromatic transition-state theory, carbocation structure stability, generalization of SN1 and SN2, E1 and E2 type reactions.
Uren per week
Onderwijsvorm Hoorcollege (LC), Opdracht (ASM)
Toetsvorm Schriftelijk tentamen (WE)
(Written exam. Max number of points is 100. Mark = number of points / 10, rounded off to the nearest 0.5 mark (except between 5 and 6, where rounding takes place to the nearest integer mark).)
Vaksoort master
Coördinator Prof. Dr. S. Harutyunyan
Docent(en) Prof. Dr. S. Harutyunyan ,prof. dr. S. Otto
Verplichte literatuur
Titel Auteur ISBN Prijs
Modern Physical Organic Chemistry (Chapters 7, 8, 9, 10, 11, 15)
Anslyn & Dougherty 1-891389-31-9
Opmerkingen The course unit assumes prior knowledge acquired from Organic Chemistry 1 and 2 and Physical Chemistry 2 from the Chemistry degree programme.
For access to the details concerning which parts of the chapters are part of the course material, please enrol first via ProgressWWW and then visit the course’s Nestor site.
Opgenomen in
Opleiding Jaar Periode Type
MSc Chemistry: Advanced Materials  ( Core Programme) - semester I a verplicht
MSc Chemistry: Catalysis and Green Chemistry  ( Core Programme) - semester I a verplicht
MSc Chemistry: Chemical Biology  ( Core Programme) - semester I a verplicht
MSc Chemistry: Erasmus Mundus Theoretical Chemistry and Computing Modelling  (Core Programma) 1 semester I a verplicht
MSc Chemistry: Science, Business and Policy  ( Science, Business and Policy) 1 semester I a verplicht
MSc Courses for Exchange Students: Chemistry - Chemical Engineering - semester I a Chemistry
MSc Nanoscience  (Optional Courses) - semester I a keuze